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Items: 1 to 20 of 28


Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell Related Diseases.

Zhong Y, Johnson AJ, Byrd JC, Dubovsky JA.

Postdoc J. 2014 Jun;2(6):1-11.


IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma.

Carson CC, Moschos SJ, Edmiston SN, Darr DB, Nikolaishvili-Feinberg N, Groben PA, Zhou X, Kuan PF, Pandey S, Chan KT, Jordan JL, Hao H, Frank JS, Hopkinson DA, Gibbs DC, Alldredge VD, Parrish E, Hanna SC, Berkowitz P, Rubenstein DS, Miller CR, Bear JE, Ollila DW, Sharpless NE, Conway K, Thomas NE.

Clin Cancer Res. 2015 May 1;21(9):2167-76. doi: 10.1158/1078-0432.CCR-14-1826.


Survey of phosphorylation near drug binding sites in the Protein Data Bank (PDB) and their effects.

Smith KP, Gifford KM, Waitzman JS, Rice SE.

Proteins. 2015 Jan;83(1):25-36. doi: 10.1002/prot.24605. Epub 2014 Nov 18.


Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.

Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH.

Sci Signal. 2013 Aug 27;6(290):ra76. doi: 10.1126/scisignal.2004298.


Substrate recognition of PLCγ1 via a specific docking surface on Itk.

Xie Q, Joseph RE, Fulton DB, Andreotti AH.

J Mol Biol. 2013 Feb 22;425(4):683-96. doi: 10.1016/j.jmb.2012.10.023. Epub 2012 Dec 3.


DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.

Hey F, Czyzewicz N, Jones P, Sablitzky F.

J Biol Chem. 2012 Sep 7;287(37):31073-84. doi: 10.1074/jbc.M112.346767. Epub 2012 Jul 24.


In Vivo Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell Kinase.

Levytskyy RM, Hirve N, Guimond DM, Min L, Andreotti AH, Tsoukas CD.

J Signal Transduct. 2012;2012:694386. doi: 10.1155/2012/694386. Epub 2012 May 9.


SH3 domain tyrosine phosphorylation--sites, role and evolution.

Tatárová Z, Brábek J, Rösel D, Novotný M.

PLoS One. 2012;7(5):e36310. doi: 10.1371/journal.pone.0036310. Epub 2012 May 15.


Itk: the rheostat of the T cell response.

Grasis JA, Tsoukas CD.

J Signal Transduct. 2011;2011:297868. doi: 10.1155/2011/297868. Epub 2011 Apr 7.


Identification of an allosteric signaling network within Tec family kinases.

Joseph RE, Xie Q, Andreotti AH.

J Mol Biol. 2010 Oct 22;403(2):231-42. doi: 10.1016/j.jmb.2010.08.035. Epub 2010 Sep 6.


T-cell signaling regulated by the Tec family kinase, Itk.

Andreotti AH, Schwartzberg PL, Joseph RE, Berg LJ.

Cold Spring Harb Perspect Biol. 2010 Jul;2(7):a002287. doi: 10.1101/cshperspect.a002287. Epub 2010 Jun 2. Review.


In vivo significance of ITK-SLP-76 interaction in cytokine production.

Grasis JA, Guimond DM, Cam NR, Herman K, Magotti P, Lambris JD, Tsoukas CD.

Mol Cell Biol. 2010 Jul;30(14):3596-609. doi: 10.1128/MCB.01657-09. Epub 2010 May 10.


T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.

Berge T, Sundvold-Gjerstad V, Granum S, Andersen TC, Holthe GB, Claesson-Welsh L, Andreotti AH, Inngjerdingen M, Spurkland A.

PLoS One. 2010 Mar 18;5(3):e9761. doi: 10.1371/journal.pone.0009761.


Disrupting the intermolecular self-association of Itk enhances T cell signaling.

Min L, Wu W, Joseph RE, Fulton DB, Berg L, Andreotti AH.

J Immunol. 2010 Apr 15;184(8):4228-35. doi: 10.4049/jimmunol.0901908. Epub 2010 Mar 17.


Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.

Min L, Joseph RE, Fulton DB, Andreotti AH.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21143-8. doi: 10.1073/pnas.0911309106. Epub 2009 Dec 1.


ITK inhibitors in inflammation and immune-mediated disorders.

Sahu N, August A.

Curr Top Med Chem. 2009;9(8):690-703. Review.


SH2-dependent autophosphorylation within the Tec family kinase Itk.

Joseph RE, Severin A, Min L, Fulton DB, Andreotti AH.

J Mol Biol. 2009 Aug 7;391(1):164-77. doi: 10.1016/j.jmb.2009.06.023. Epub 2009 Jun 11.


The tyrosine kinase network regulating mast cell activation.

Gilfillan AM, Rivera J.

Immunol Rev. 2009 Mar;228(1):149-69. doi: 10.1111/j.1600-065X.2008.00742.x. Review.


Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk.

Readinger JA, Mueller KL, Venegas AM, Horai R, Schwartzberg PL.

Immunol Rev. 2009 Mar;228(1):93-114. doi: 10.1111/j.1600-065X.2008.00757.x. Review.


Conformational snapshots of Tec kinases during signaling.

Joseph RE, Andreotti AH.

Immunol Rev. 2009 Mar;228(1):74-92. doi: 10.1111/j.1600-065X.2008.00740.x.

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