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Items: 1 to 20 of 45

1.

An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis.

Stepanova DS, Semenova G, Kuo YM, Andrews AJ, Ammoun S, Hanemann CO, Chernoff J.

Cancer Res. 2017 Sep 15;77(18):5026-5038. doi: 10.1158/0008-5472.CAN-16-2834. Epub 2017 Jul 20.

PMID:
28729415
2.

Molecular Mechanisms Involved in Schwann Cell Plasticity.

Boerboom A, Dion V, Chariot A, Franzen R.

Front Mol Neurosci. 2017 Feb 17;10:38. doi: 10.3389/fnmol.2017.00038. eCollection 2017. Review.

3.

Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target.

Bassiri K, Ferluga S, Sharma V, Syed N, Adams CL, Lasonder E, Hanemann CO.

EBioMedicine. 2017 Feb;16:76-86. doi: 10.1016/j.ebiom.2017.01.020. Epub 2017 Jan 18.

4.

Rac1-Mediated DNA Damage and Inflammation Promote Nf2 Tumorigenesis but Also Limit Cell-Cycle Progression.

Shi Y, Bollam SR, White SM, Laughlin SZ, Graham GT, Wadhwa M, Chen H, Nguyen C, Vitte J, Giovannini M, Toretsky J, Yi C.

Dev Cell. 2016 Nov 21;39(4):452-465. doi: 10.1016/j.devcel.2016.09.027. Epub 2016 Nov 3.

5.

Inhibiting p21-Activated Kinase Induces Cell Death in Vestibular Schwannoma and Meningioma via Mitotic Catastrophe.

Mercado-Pimentel ME, Miller C, Rolph DN, Villalobos EF, Dunn AM, Mohan PM, Igarashi S, Liu X, Yrun-Duffy M, Patel NK, Read CM, Francis RH, Lane AI, Murugesh S, Jacob A.

Otol Neurotol. 2017 Jan;38(1):139-146.

6.

Role of Merlin/NF2 inactivation in tumor biology.

Petrilli AM, Fernández-Valle C.

Oncogene. 2016 Feb 4;35(5):537-48. doi: 10.1038/onc.2015.125. Epub 2015 Apr 20. Review.

7.

The p53/mouse double minute 2 homolog complex deregulation in merlin-deficient tumours.

Ammoun S, Schmid MC, Zhou L, Hilton DA, Barczyk M, Hanemann CO.

Mol Oncol. 2015 Jan;9(1):236-48. doi: 10.1016/j.molonc.2014.08.005. Epub 2014 Aug 27.

8.

Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα.

Lu Y, Liu X, Jiao Y, Xiong X, Wang E, Wang X, Zhang Z, Zhang H, Pan L, Guan Y, Cai D, Ning G, Li X.

J Clin Invest. 2014 Aug;124(8):3501-13. doi: 10.1172/JCI74438. Epub 2014 Jul 8.

9.

p75NTR is highly expressed in vestibular schwannomas and promotes cell survival by activating nuclear transcription factor κB.

Ahmad I, Yue WY, Fernando A, Clark JJ, Woodson EA, Hansen MR.

Glia. 2014 Oct;62(10):1699-712. doi: 10.1002/glia.22709. Epub 2014 Jun 26.

10.

Mitogen Activated Protein Kinase Family Proteins and c-jun Signaling in Injury-induced Schwann Cell Plasticity.

Lee HJ, Shin YK, Park HT.

Exp Neurobiol. 2014 Jun;23(2):130-7. doi: 10.5607/en.2014.23.2.130. Epub 2014 Jun 13. Review.

11.

Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation.

Lamarca A, Gella A, Martiañez T, Segura M, Figueiro-Silva J, Grijota-Martinez C, Trullas R, Casals N.

PLoS One. 2014 Jun 6;9(6):e98998. doi: 10.1371/journal.pone.0098998. eCollection 2014.

12.

Molecular insights into NF2/Merlin tumor suppressor function.

Cooper J, Giancotti FG.

FEBS Lett. 2014 Aug 19;588(16):2743-52. doi: 10.1016/j.febslet.2014.04.001. Epub 2014 Apr 12. Review.

13.

Proteomic screening identifies a YAP-driven signaling network linked to tumor cell proliferation in human schwannomas.

Boin A, Couvelard A, Couderc C, Brito I, Filipescu D, Kalamarides M, Bedossa P, De Koning L, Danelsky C, Dubois T, Hupé P, Louvard D, Lallemand D.

Neuro Oncol. 2014 Sep;16(9):1196-209. doi: 10.1093/neuonc/nou020. Epub 2014 Feb 20.

14.

FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas.

Licciulli S, Maksimoska J, Zhou C, Troutman S, Kota S, Liu Q, Duron S, Campbell D, Chernoff J, Field J, Marmorstein R, Kissil JL.

J Biol Chem. 2013 Oct 4;288(40):29105-14. doi: 10.1074/jbc.M113.510933. Epub 2013 Aug 19.

15.

Inhibition of c-Jun N-terminal kinase activity enhances vestibular schwannoma cell sensitivity to gamma irradiation.

Yue WY, Clark JJ, Telisak M, Hansen MR.

Neurosurgery. 2013 Sep;73(3):506-16. doi: 10.1227/01.neu.0000431483.10031.89.

16.

Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells.

Doddrell RD, Dun XP, Shivane A, Feltri ML, Wrabetz L, Wegner M, Sock E, Hanemann CO, Parkinson DB.

Brain. 2013 Feb;136(Pt 2):549-63. doi: 10.1093/brain/aws353.

17.

N-cadherin expression is regulated by UTP in schwannoma cells.

Martiáñez T, Lamarca A, Casals N, Gella A.

Purinergic Signal. 2013 Jun;9(2):259-70. doi: 10.1007/s11302-012-9348-x. Epub 2012 Dec 28.

18.

Neurofibromatosis type 2 protein, NF2: an uncoventional cell cycle regulator.

Beltrami S, Kim R, Gordon J.

Anticancer Res. 2013 Jan;33(1):1-11. Review.

19.

Rac1 controls Schwann cell myelination through cAMP and NF2/merlin.

Guo L, Moon C, Niehaus K, Zheng Y, Ratner N.

J Neurosci. 2012 Nov 28;32(48):17251-61. doi: 10.1523/JNEUROSCI.2461-12.2012.

20.

Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors.

Manchanda PK, Jones GN, Lee AA, Pringle DR, Zhang M, Yu L, La Perle KM, Kirschner LS.

Oncogene. 2013 Jul 25;32(30):3491-9. doi: 10.1038/onc.2012.374. Epub 2012 Oct 8.

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