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Restriction of protein synthesis abolishes senescence features at cellular and organismal levels.

Takauji Y, Wada T, Takeda A, Kudo I, Miki K, Fujii M, Ayusawa D.

Sci Rep. 2016 Jan 5;6:18722. doi: 10.1038/srep18722.


Functional significance of point mutations in stress chaperone mortalin and their relevance to Parkinson disease.

Wadhwa R, Ryu J, Ahn HM, Saxena N, Chaudhary A, Yun CO, Kaul SC.

J Biol Chem. 2015 Mar 27;290(13):8447-56. doi: 10.1074/jbc.M114.627463.


Identification and functional characterization of nuclear mortalin in human carcinogenesis.

Ryu J, Kaul Z, Yoon AR, Liu Y, Yaguchi T, Na Y, Ahn HM, Gao R, Choi IK, Yun CO, Kaul SC, Wadhwa R.

J Biol Chem. 2014 Sep 5;289(36):24832-44. doi: 10.1074/jbc.M114.565929.


Mortalin, apoptosis, and neurodegeneration.

Londono C, Osorio C, Gama V, Alzate O.

Biomolecules. 2012 Mar 1;2(1):143-64. doi: 10.3390/biom2010143.


Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.

Burbulla LF, Fitzgerald JC, Stegen K, Westermeier J, Thost AK, Kato H, Mokranjac D, Sauerwald J, Martins LM, Woitalla D, Rapaport D, Riess O, Proikas-Cezanne T, Rasse TM, Krüger R.

Cell Death Dis. 2014 Apr 17;5:e1180. doi: 10.1038/cddis.2014.103.


Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model.

Zhu JY, Vereshchagina N, Sreekumar V, Burbulla LF, Costa AC, Daub KJ, Woitalla D, Martins LM, Krüger R, Rasse TM.

PLoS One. 2013 Dec 30;8(12):e83714. doi: 10.1371/journal.pone.0083714.


Down-regulation of mortalin exacerbates Aβ-mediated mitochondrial fragmentation and dysfunction.

Park SJ, Shin JH, Jeong JI, Song JH, Jo YK, Kim ES, Lee EH, Hwang JJ, Lee EK, Chung SJ, Koh JY, Jo DG, Cho DH.

J Biol Chem. 2014 Jan 24;289(4):2195-204. doi: 10.1074/jbc.M113.492587.


Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization.

Saxena N, Katiyar SP, Liu Y, Grover A, Gao R, Sundar D, Kaul SC, Wadhwa R.

Biosci Rep. 2013 Oct 16;33(5). pii: e00073. doi: 10.1042/BSR20130034.


Identifications small molecules inhibitor of p53-mortalin complex for cancer drug using virtual screening.

Utomo DH, Widodo N, Rifa'i M.

Bioinformation. 2012;8(9):426-9. doi: 10.6026/97320630008426.


Allostery in the Hsp70 chaperone proteins.

Zuiderweg ER, Bertelsen EB, Rousaki A, Mayer MP, Gestwicki JE, Ahmad A.

Top Curr Chem. 2013;328:99-153. doi: 10.1007/128_2012_323. Review.


CCR5 blockade is well tolerated and induces changes in the tissue distribution of CCR5+ and CD25+ T cells in healthy, SIV-uninfected rhesus macaques.

Taaffe JE, Bosinger SE, Del Prete GQ, Else JG, Ratcliffe S, Ward CD, Migone T, Paiardini M, Silvestri G.

J Med Primatol. 2012 Feb;41(1):24-42. doi: 10.1111/j.1600-0684.2011.00521.x.


Cellular Senescence - its role in cancer and the response to ionizing radiation.

Sabin RJ, Anderson RM.

Genome Integr. 2011 Aug 11;2(1):7. doi: 10.1186/2041-9414-2-7.


Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones.

Rousaki A, Miyata Y, Jinwal UK, Dickey CA, Gestwicki JE, Zuiderweg ER.

J Mol Biol. 2011 Aug 19;411(3):614-32. doi: 10.1016/j.jmb.2011.06.003.


Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis.

Burbulla LF, Schelling C, Kato H, Rapaport D, Woitalla D, Schiesling C, Schulte C, Sharma M, Illig T, Bauer P, Jung S, Nordheim A, Schöls L, Riess O, Krüger R.

Hum Mol Genet. 2010 Nov 15;19(22):4437-52. doi: 10.1093/hmg/ddq370.


Protein homeostasis and aging: The importance of exquisite quality control.

Koga H, Kaushik S, Cuervo AM.

Ageing Res Rev. 2011 Apr;10(2):205-15. doi: 10.1016/j.arr.2010.02.001. Review.


Proproliferative functions of Drosophila small mitochondrial heat shock protein 22 in human cells.

Wadhwa R, Ryu J, Gao R, Choi IK, Morrow G, Kaur K, Kim I, Kaul SC, Yun CO, Tanguay RM.

J Biol Chem. 2010 Feb 5;285(6):3833-9. doi: 10.1074/jbc.M109.080424.


Neurochemical approaches in the laboratory diagnosis of Parkinson and Parkinson dementia syndromes: a review.

Jesse S, Steinacker P, Lehnert S, Gillardon F, Hengerer B, Otto M.

CNS Neurosci Ther. 2009 Summer;15(2):157-82. doi: 10.1111/j.1755-5949.2008.00064.x. Review.


Chaperoning erythropoiesis.

Weiss MJ, dos Santos CO.

Blood. 2009 Mar 5;113(10):2136-44. doi: 10.1182/blood-2008-09-115238. Review.


Molecular chaperones regulate p53 and suppress senescence programs.

Sherman MY, Gabai V, O'Callaghan C, Yaglom J.

FEBS Lett. 2007 Jul 31;581(19):3711-5. Review. Erratum in: FEBS Lett. 2007 Dec 11;581(29):5732. Sherman, Michael [corrected to Sherman, Michael Y].


On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60.

Deocaris CC, Kaul SC, Wadhwa R.

Cell Stress Chaperones. 2006 Summer;11(2):116-28. Review.

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