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Items: 1 to 20 of 42


Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim.

Nguyen M, Cencic R, Ertel F, Bernier C, Pelletier J, Roulston A, Silvius JR, Shore GC.

BMC Cancer. 2015 Aug 1;15:568. doi: 10.1186/s12885-015-1582-5.


Tailored fragments of roseophilin selectively antagonize Mcl-1 in vitro.

Bracken JD, Carlson AD, Frederich JH, Nguyen M, Shore GC, Harran PG.

Tetrahedron Lett. 2015 Jun 3;56(23):3612-3616.


Regulated necrotic cell death: the passive aggressive side of Bax and Bak.

Karch J, Molkentin JD.

Circ Res. 2015 May 22;116(11):1800-9. doi: 10.1161/CIRCRESAHA.116.305421. Review.


Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.

Hockings C, Anwari K, Ninnis RL, Brouwer J, O'Hely M, Evangelista M, Hinds MG, Czabotar PE, Lee EF, Fairlie WD, Dewson G, Kluck RM.

Cell Death Dis. 2015 Apr 23;6:e1735. doi: 10.1038/cddis.2015.105.


BIM-mediated membrane insertion of the BAK pore domain is an essential requirement for apoptosis.

Weber K, Harper N, Schwabe J, Cohen GM.

Cell Rep. 2013 Oct 31;5(2):409-20. doi: 10.1016/j.celrep.2013.09.010. Epub 2013 Oct 10.


Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival.

Lewis A, Hayashi T, Su TP, Betenbaugh MJ.

J Bioenerg Biomembr. 2014 Feb;46(1):1-15. Review.


Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate.

Bogdał MN, Hat B, Kochańczyk M, Lipniacki T.

BMC Syst Biol. 2013 Jul 24;7:67. doi: 10.1186/1752-0509-7-67.


Infarct-induced steroidogenic acute regulatory protein: a survival role in cardiac fibroblasts.

Anuka E, Yivgi-Ohana N, Eimerl S, Garfinkel B, Melamed-Book N, Chepurkol E, Aravot D, Zinman T, Shainberg A, Hochhauser E, Orly J.

Mol Endocrinol. 2013 Sep;27(9):1502-17. doi: 10.1210/me.2013-1006. Epub 2013 Jul 5.


Programming cancer cells for high expression levels of Mcl1.

Ertel F, Nguyen M, Roulston A, Shore GC.

EMBO Rep. 2013 Apr;14(4):328-36. doi: 10.1038/embor.2013.20. Epub 2013 Mar 12. Review.


Controlling subcellular delivery to optimize therapeutic effect.

Mossalam M, Dixon AS, Lim CS.

Ther Deliv. 2010 Jul;1(1):169-93. Review.


Elucidating cytochrome C release from mitochondria: insights from an in silico three-dimensional model.

Tam ZY, Cai YH, Gunawan R.

Biophys J. 2010 Nov 17;99(10):3155-63. doi: 10.1016/j.bpj.2010.09.041.


BH3 domains other than Bim and Bid can directly activate Bax/Bak.

Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T.

J Biol Chem. 2011 Jan 7;286(1):491-501. doi: 10.1074/jbc.M110.167148. Epub 2010 Nov 1.


Tyrosine dephosphorylation is required for Bak activation in apoptosis.

Fox JL, Ismail F, Azad A, Ternette N, Leverrier S, Edelmann MJ, Kessler BM, Leigh IM, Jackson S, Storey A.

EMBO J. 2010 Nov 17;29(22):3853-68. doi: 10.1038/emboj.2010.244. Epub 2010 Oct 19.


Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor.

Lazarou M, Stojanovski D, Frazier AE, Kotevski A, Dewson G, Craigen WJ, Kluck RM, Vaux DL, Ryan MT.

J Biol Chem. 2010 Nov 19;285(47):36876-83. doi: 10.1074/jbc.M110.159301. Epub 2010 Sep 17.


Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif.

Ding J, Zhang Z, Roberts GJ, Falcone M, Miao Y, Shao Y, Zhang XC, Andrews DW, Lin J.

J Biol Chem. 2010 Sep 10;285(37):28749-63. doi: 10.1074/jbc.M110.148361. Epub 2010 Jun 28.


MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria.

Zaltsman Y, Shachnai L, Yivgi-Ohana N, Schwarz M, Maryanovich M, Houtkooper RH, Vaz FM, De Leonardis F, Fiermonte G, Palmieri F, Gillissen B, Daniel PT, Jimenez E, Walsh S, Koehler CM, Roy SS, Walter L, Hajnóczky G, Gross A.

Nat Cell Biol. 2010 Jun;12(6):553-562. doi: 10.1038/ncb2057. Epub 2010 May 2.


Bax forms an oligomer via separate, yet interdependent, surfaces.

Zhang Z, Zhu W, Lapolla SM, Miao Y, Shao Y, Falcone M, Boreham D, McFarlane N, Ding J, Johnson AE, Zhang XC, Andrews DW, Lin J.

J Biol Chem. 2010 Jun 4;285(23):17614-27. doi: 10.1074/jbc.M110.113456. Epub 2010 Apr 9.


IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation.

Benard G, Neutzner A, Peng G, Wang C, Livak F, Youle RJ, Karbowski M.

EMBO J. 2010 Apr 21;29(8):1458-71. doi: 10.1038/emboj.2010.39. Epub 2010 Mar 18.


Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction.

Samudio I, Harmancey R, Fiegl M, Kantarjian H, Konopleva M, Korchin B, Kaluarachchi K, Bornmann W, Duvvuri S, Taegtmeyer H, Andreeff M.

J Clin Invest. 2010 Jan;120(1):142-56. doi: 10.1172/JCI38942. Epub 2009 Dec 21.


Apoptosis: it's BAK to VDAC.

Shore GC.

EMBO Rep. 2009 Dec;10(12):1311-3. doi: 10.1038/embor.2009.249. Epub 2009 Nov 13. Review. No abstract available.

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