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Items: 1 to 20 of 22

1.

Tay-Sachs disease mutations in HEXA target the α chain of hexosaminidase A to endoplasmic reticulum-associated degradation.

Dersh D, Iwamoto Y, Argon Y.

Mol Biol Cell. 2016 Dec 1;27(24):3813-3827. Epub 2016 Sep 28.

2.

Construction of a hybrid β-hexosaminidase subunit capable of forming stable homodimers that hydrolyze GM2 ganglioside in vivo.

Tropak MB, Yonekawa S, Karumuthil-Melethil S, Thompson P, Wakarchuk W, Gray SJ, Walia JS, Mark BL, Mahuran D.

Mol Ther Methods Clin Dev. 2016 Mar 2;3:15057. doi: 10.1038/mtm.2015.57. eCollection 2016.

3.

Probing the Catalytic Mechanism of Vibrio harveyi GH20 β-N-Acetylglucosaminidase by Chemical Rescue.

Meekrathok P, Suginta W.

PLoS One. 2016 Feb 12;11(2):e0149228. doi: 10.1371/journal.pone.0149228. eCollection 2016.

4.

Ganglioside biochemistry.

Kolter T.

ISRN Biochem. 2012 Dec 19;2012:506160. doi: 10.5402/2012/506160. eCollection 2012. Review.

5.

Expression, purification, crystallization and preliminary crystallographic analysis of a GH20 β-N-acetylglucosaminidase from the marine bacterium Vibrio harveyi.

Meekrathok P, Bürger M, Porfetye AT, Vetter IR, Suginta W.

Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):427-33. doi: 10.1107/S2053230X1500415X. Epub 2015 Mar 20.

6.

Computational study of β-N-acetylhexosaminidase from Talaromyces flavus, a glycosidase with high substrate flexibility.

Kulik N, Slámová K, Ettrich R, Křen V.

BMC Bioinformatics. 2015 Jan 28;16:28. doi: 10.1186/s12859-015-0465-8.

7.

Molecular phylogeny and predicted 3D structure of plant beta-D-N-acetylhexosaminidase.

Hossain MA, Roslan HA.

ScientificWorldJournal. 2014;2014:186029. doi: 10.1155/2014/186029. Epub 2014 Jul 20.

8.

A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two β-GlcNAcase homologs.

Liu T, Guo P, Zhou Y, Wang J, Chen L, Yang H, Qian X, Yang Q.

Sci Rep. 2014 Aug 26;4:6188. doi: 10.1038/srep06188.

9.

Incidence and carrier frequency of Sandhoff disease in Saskatchewan determined using a novel substrate with detection by tandem mass spectrometry and molecular genetic analysis.

Fitterer B, Hall P, Antonishyn N, Desikan R, Gelb M, Lehotay D.

Mol Genet Metab. 2014 Mar;111(3):382-389. doi: 10.1016/j.ymgme.2014.01.002. Epub 2014 Jan 13.

10.

In cellulo examination of a beta-alpha hybrid construct of beta-hexosaminidase A subunits, reported to interact with the GM2 activator protein and hydrolyze GM2 ganglioside.

Sinici I, Yonekawa S, Tkachyova I, Gray SJ, Samulski RJ, Wakarchuk W, Mark BL, Mahuran DJ.

PLoS One. 2013;8(3):e57908. doi: 10.1371/journal.pone.0057908. Epub 2013 Mar 4.

11.

Crystal structures of a glycoside hydrolase family 20 lacto-N-biosidase from Bifidobacterium bifidum.

Ito T, Katayama T, Hattie M, Sakurama H, Wada J, Suzuki R, Ashida H, Wakagi T, Yamamoto K, Stubbs KA, Fushinobu S.

J Biol Chem. 2013 Apr 26;288(17):11795-806. doi: 10.1074/jbc.M112.420109. Epub 2013 Mar 11.

12.

Characterization of the mutant β-subunit of β-hexosaminidase for dimer formation responsible for the adult form of Sandhoff disease with the motor neuron disease phenotype.

Yamada K, Takado Y, Kato YS, Yamada Y, Ishiguro H, Wakamatsu N.

J Biochem. 2013 Jan;153(1):111-9. doi: 10.1093/jb/mvs131. Epub 2012 Nov 5.

14.

Structural basis for the substrate specificity of a novel β-N-acetylhexosaminidase StrH protein from Streptococcus pneumoniae R6.

Jiang YL, Yu WL, Zhang JW, Frolet C, Di Guilmi AM, Zhou CZ, Vernet T, Chen Y.

J Biol Chem. 2011 Dec 16;286(50):43004-12. doi: 10.1074/jbc.M111.256578. Epub 2011 Oct 19.

15.

Crystal structure of β-hexosaminidase B in complex with pyrimethamine, a potential pharmacological chaperone.

Bateman KS, Cherney MM, Mahuran DJ, Tropak M, James MN.

J Med Chem. 2011 Mar 10;54(5):1421-9. doi: 10.1021/jm101443u. Epub 2011 Jan 25.

16.

Structural determinants of an insect beta-N-Acetyl-D-hexosaminidase specialized as a chitinolytic enzyme.

Liu T, Zhang H, Liu F, Wu Q, Shen X, Yang Q.

J Biol Chem. 2011 Feb 11;286(6):4049-58. doi: 10.1074/jbc.M110.184796. Epub 2010 Nov 24.

17.

A sensitive fluorescence-based assay for monitoring GM2 ganglioside hydrolysis in live patient cells and their lysates.

Tropak MB, Bukovac SW, Rigat BA, Yonekawa S, Wakarchuk W, Mahuran DJ.

Glycobiology. 2010 Mar;20(3):356-65. doi: 10.1093/glycob/cwp183. Epub 2009 Nov 16.

18.

Phylogenetic analyses suggest multiple changes of substrate specificity within the glycosyl hydrolase 20 family.

Intra J, Pavesi G, Horner DS.

BMC Evol Biol. 2008 Jul 22;8:214. doi: 10.1186/1471-2148-8-214.

19.

Production of recombinant beta-hexosaminidase A, a potential enzyme for replacement therapy for Tay-Sachs and Sandhoff diseases, in the methylotrophic yeast Ogataea minuta.

Akeboshi H, Chiba Y, Kasahara Y, Takashiba M, Takaoka Y, Ohsawa M, Tajima Y, Kawashima I, Tsuji D, Itoh K, Sakuraba H, Jigami Y.

Appl Environ Microbiol. 2007 Aug;73(15):4805-12. Epub 2007 Jun 8.

20.

Structure of the dimeric N-glycosylated form of fungal beta-N-acetylhexosaminidase revealed by computer modeling, vibrational spectroscopy, and biochemical studies.

Ettrich R, Kopecký V Jr, Hofbauerová K, Baumruk V, Novák P, Pompach P, Man P, Plíhal O, Kutý M, Kulik N, Sklenár J, Ryslavá H, Kren V, Bezouska K.

BMC Struct Biol. 2007 May 17;7:32.

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