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Items: 1 to 20 of 52


The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age.

Hosokawa K, MacArthur BD, Ikushima YM, Toyama H, Masuhiro Y, Hanazawa S, Suda T, Arai F.

Nat Commun. 2017 Oct 6;8(1):804. doi: 10.1038/s41467-017-00935-4.


Intramolecular autoinhibition of checkpoint kinase 1 is mediated by conserved basic motifs of the C-terminal kinase-associated 1 domain.

Emptage RP, Schoenberger MJ, Ferguson KM, Marmorstein R.

J Biol Chem. 2017 Nov 17;292(46):19024-19033. doi: 10.1074/jbc.M117.811265. Epub 2017 Sep 25.


Activation of CHK1 in Supporting Cells Indirectly Promotes Hair Cell Survival.

Jadali A, Ying YM, Kwan KY.

Front Cell Neurosci. 2017 May 18;11:137. doi: 10.3389/fncel.2017.00137. eCollection 2017.


Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1.

Greer YE, Gao B, Yang Y, Nussenzweig A, Rubin JS.

PLoS One. 2017 Jan 26;12(1):e0170903. doi: 10.1371/journal.pone.0170903. eCollection 2017.


KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage.

Gong EY, Smits VA, Fumagallo F, Piscitello D, Morrice N, Freire R, Gillespie DA.

Sci Rep. 2015 Jun 3;5:10856. doi: 10.1038/srep10856.


Acquisition of meiotic DNA repair regulators maintain genome stability in glioblastoma.

Rivera M, Wu Q, Hamerlik P, Hjelmeland AB, Bao S, Rich JN.

Cell Death Dis. 2015 Apr 23;6:e1732. doi: 10.1038/cddis.2015.75.


The fork and the kinase: a DNA replication tale from a CHK1 perspective.

González Besteiro MA, Gottifredi V.

Mutat Res Rev Mutat Res. 2015 Jan-Mar;763:168-80. doi: 10.1016/j.mrrev.2014.10.003. Epub 2014 Oct 22. Review.


A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response.

Blasius M, Wagner SA, Choudhary C, Bartek J, Jackson SP.

Genes Dev. 2014 Sep 15;28(18):1977-82. doi: 10.1101/gad.246272.114. Epub 2014 Sep 4.


Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.

Bolderson E, Petermann E, Croft L, Suraweera A, Pandita RK, Pandita TK, Helleday T, Khanna KK, Richard DJ.

Nucleic Acids Res. 2014 Jun;42(10):6326-36. doi: 10.1093/nar/gku276. Epub 2014 Apr 20.


WRN loss induces switching of telomerase-independent mechanisms of telomere elongation.

Gocha AR, Acharya S, Groden J.

PLoS One. 2014 Apr 7;9(4):e93991. doi: 10.1371/journal.pone.0093991. eCollection 2014.


Calanquinone A induces anti-glioblastoma activity through glutathione-involved DNA damage and AMPK activation.

Liu FL, Hsu JL, Lee YJ, Dong YS, Kung FL, Chen CS, Guh JH.

Eur J Pharmacol. 2014 May 5;730:90-101. doi: 10.1016/j.ejphar.2014.02.029. Epub 2014 Mar 6.


Targeted inhibition of ATR or CHEK1 reverses radioresistance in oral squamous cell carcinoma cells with distal chromosome arm 11q loss.

Sankunny M, Parikh RA, Lewis DW, Gooding WE, Saunders WS, Gollin SM.

Genes Chromosomes Cancer. 2014 Feb;53(2):129-43. doi: 10.1002/gcc.22125. Epub 2013 Nov 25.


Regulation of nucleotide excision repair by nuclear lamin b1.

Butin-Israeli V, Adam SA, Goldman RD.

PLoS One. 2013 Jul 24;8(7):e69169. doi: 10.1371/journal.pone.0069169. Print 2013.


Targeting endogenous nuclear antigens by electrotransfer of monoclonal antibodies in living cells.

Freund G, Sibler AP, Desplancq D, Oulad-Abdelghani M, Vigneron M, Gannon J, Van Regenmortel MH, Weiss E.

MAbs. 2013 Jul-Aug;5(4):518-22. doi: 10.4161/mabs.25084. Epub 2013 May 29.


Roles of Chk1 in cell biology and cancer therapy.

Zhang Y, Hunter T.

Int J Cancer. 2014 Mar 1;134(5):1013-23. doi: 10.1002/ijc.28226. Epub 2013 May 28. Review.


The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial design.

Thompson R, Eastman A.

Br J Clin Pharmacol. 2013 Sep;76(3):358-69. doi: 10.1111/bcp.12139. Review.


HMGA2 inhibits apoptosis through interaction with ATR-CHK1 signaling complex in human cancer cells.

Natarajan S, Hombach-Klonisch S, Dröge P, Klonisch T.

Neoplasia. 2013 Mar;15(3):263-80.


Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblasts.

Smith-Roe SL, Patel SS, Zhou Y, Simpson DA, Rao S, Ibrahim JG, Cordeiro-Stone M, Kaufmann WK.

Cell Cycle. 2013 Jan 15;12(2):332-45. doi: 10.4161/cc.23177. Epub 2012 Jan 15.


BRCA1-dependent Chk1 phosphorylation triggers partial chromatin disassociation of phosphorylated Chk1 and facilitates S-phase cell cycle arrest.

Yarden RI, Metsuyanim S, Pickholtz I, Shabbeer S, Tellio H, Papa MZ.

Int J Biochem Cell Biol. 2012 Nov;44(11):1761-9. doi: 10.1016/j.biocel.2012.06.026. Epub 2012 Jun 26.


The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels.

Tichy ED, Pillai R, Deng L, Tischfield JA, Hexley P, Babcock GF, Stambrook PJ.

Stem Cell Res. 2012 Sep;9(2):124-34. doi: 10.1016/j.scr.2012.05.004. Epub 2012 May 22.

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