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Items: 19


When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling.

Nguyen LK, Kolch W, Kholodenko BN.

Cell Commun Signal. 2013 Jul 31;11:52. doi: 10.1186/1478-811X-11-52. Review.


Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity.

Hurst JH, Dohlman HG.

J Biol Chem. 2013 Jun 28;288(26):18660-71. doi: 10.1074/jbc.M113.475707. Epub 2013 May 3.


Ras protein/cAMP-dependent protein kinase signaling is negatively regulated by a deubiquitinating enzyme, Ubp3, in yeast.

Li Y, Wang Y.

J Biol Chem. 2013 Apr 19;288(16):11358-65. doi: 10.1074/jbc.M112.449751. Epub 2013 Mar 8.


Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity.

Hao N, Yildirim N, Nagiec MJ, Parnell SC, Errede B, Dohlman HG, Elston TC.

Mol Biol Cell. 2012 Oct;23(19):3899-910. doi: 10.1091/mbc.E12-04-0333. Epub 2012 Aug 8.


Cell cycle-dependent phosphorylation and ubiquitination of a G protein alpha subunit.

Torres MP, Clement ST, Cappell SD, Dohlman HG.

J Biol Chem. 2011 Jun 10;286(23):20208-16. doi: 10.1074/jbc.M111.239343. Epub 2011 Apr 26.


Systematic analysis of essential genes reveals important regulators of G protein signaling.

Cappell SD, Baker R, Skowyra D, Dohlman HG.

Mol Cell. 2010 Jun 11;38(5):746-57. doi: 10.1016/j.molcel.2010.05.026.


MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase itch.

Ahn YH, Kurie JM.

J Biol Chem. 2009 Oct 23;284(43):29399-404. doi: 10.1074/jbc.M109.044958. Epub 2009 Sep 8.


G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase.

Torres MP, Lee MJ, Ding F, Purbeck C, Kuhlman B, Dokholyan NV, Dohlman HG.

J Biol Chem. 2009 Mar 27;284(13):8940-50. doi: 10.1074/jbc.M809058200. Epub 2009 Jan 27.


Signaling threshold regulation by the Ras effector IMP.

Matheny SA, White MA.

J Biol Chem. 2009 Apr 24;284(17):11007-11. doi: 10.1074/jbc.R800082200. Epub 2008 Dec 17. Review.


Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence.

Garrenton LS, Braunwarth A, Irniger S, Hurt E, K├╝nzler M, Thorner J.

Mol Cell Biol. 2009 Jan;29(2):582-601. doi: 10.1128/MCB.01019-08. Epub 2008 Nov 10.


Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.

Chen RE, Thorner J.

Biochim Biophys Acta. 2007 Aug;1773(8):1311-40. Epub 2007 May 22. Review.


Mechanisms regulating the protein kinases of Saccharomyces cerevisiae.

Rubenstein EM, Schmidt MC.

Eukaryot Cell. 2007 Apr;6(4):571-83. Epub 2007 Mar 2. Review. No abstract available.


Pheromone-induced degradation of Ste12 contributes to signal attenuation and the specificity of developmental fate.

Esch RK, Wang Y, Errede B.

Eukaryot Cell. 2006 Dec;5(12):2147-60. Epub 2006 Oct 13.


The Cdc34/SCF ubiquitination complex mediates Saccharomyces cerevisiae cell wall integrity.

Varelas X, Stuart D, Ellison MJ, Ptak C.

Genetics. 2006 Dec;174(4):1825-39. Epub 2006 Oct 8.


Dynamic studies of scaffold-dependent mating pathway in yeast.

Shao D, Zheng W, Qiu W, Ouyang Q, Tang C.

Biophys J. 2006 Dec 1;91(11):3986-4001. Epub 2006 Sep 15.


Bistability, stochasticity, and oscillations in the mitogen-activated protein kinase cascade.

Wang X, Hao N, Dohlman HG, Elston TC.

Biophys J. 2006 Mar 15;90(6):1961-78. Epub 2005 Dec 16.


A walk-through of the yeast mating pheromone response pathway.

Bardwell L.

Peptides. 2005 Feb;26(2):339-50. Review.


Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast.

Maleri S, Ge Q, Hackett EA, Wang Y, Dohlman HG, Errede B.

Mol Cell Biol. 2004 Oct;24(20):9221-38.

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