Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 210


Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease.

Kametani F, Hasegawa M.

Front Neurosci. 2018 Jan 30;12:25. doi: 10.3389/fnins.2018.00025. eCollection 2018. Review.


Allosteric Modulation of Intact γ-Secretase Structural Dynamics.

Lee JY, Feng Z, Xie XQ, Bahar I.

Biophys J. 2017 Dec 19;113(12):2634-2649. doi: 10.1016/j.bpj.2017.10.012.


Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation.

Grimm MOW, Thiel A, Lauer AA, Winkler J, Lehmann J, Regner L, Nelke C, Janitschke D, Benoist C, Streidenberger O, Stötzel H, Endres K, Herr C, Beisswenger C, Grimm HS, Bals R, Lammert F, Hartmann T.

Int J Mol Sci. 2017 Dec 19;18(12). pii: E2764. doi: 10.3390/ijms18122764.


The role of astrocytes in amyloid production and Alzheimer's disease.

Frost GR, Li YM.

Open Biol. 2017 Dec;7(12). pii: 170228. doi: 10.1098/rsob.170228. Review.


Human Induced Pluripotent Stem Cells and the Modelling of Alzheimer's Disease: The Human Brain Outside the Dish.

Tong G, Izquierdo P, Raashid RA.

Open Neurol J. 2017 Sep 30;11:27-38. doi: 10.2174/1874205X01711010027. eCollection 2017. Review.


Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease.

Grigorenko AP, Moliaka YK, Plotnikova OV, Smirnov A, Nikishina VA, Goltsov AY, Gusev F, Andreeva TV, Nelson O, Bezprozvanny I, Rogaev EI.

Oncotarget. 2017 May 30;8(47):82006-82026. doi: 10.18632/oncotarget.18299. eCollection 2017 Oct 10.


Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.

Zhou R, Yang G, Shi Y.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12731-12736. doi: 10.1073/pnas.1713605114. Epub 2017 Oct 9.


Characterizing the structural ensemble of γ-secretase using a multiscale molecular dynamics approach.

Aguayo-Ortiz R, Chávez-García C, Straub JE, Dominguez L.

Chem Sci. 2017 Aug 1;8(8):5576-5584. doi: 10.1039/c7sc00980a. Epub 2017 Jun 5.


Modifications and Trafficking of APP in the Pathogenesis of Alzheimer's Disease.

Wang X, Zhou X, Li G, Zhang Y, Wu Y, Song W.

Front Mol Neurosci. 2017 Sep 15;10:294. doi: 10.3389/fnmol.2017.00294. eCollection 2017. Review.


Amyloid beta: structure, biology and structure-based therapeutic development.

Chen GF, Xu TH, Yan Y, Zhou YR, Jiang Y, Melcher K, Xu HE.

Acta Pharmacol Sin. 2017 Sep;38(9):1205-1235. doi: 10.1038/aps.2017.28. Epub 2017 Jul 17. Review.


Versatility of presenilin 1.

Frost GR, Wong E, Li YM.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):6885-6887. doi: 10.1073/pnas.1707809114. Epub 2017 Jun 23. No abstract available.


Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice.

Prasad T, Zhu P, Verma A, Chakrabarty P, Rosario AM, Golde TE, Li Q.

Sci Rep. 2017 Jun 12;7(1):3222. doi: 10.1038/s41598-017-03397-2.


Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration.

Acx H, Serneels L, Radaelli E, Muyldermans S, Vincke C, Pepermans E, Müller U, Chávez-Gutiérrez L, De Strooper B.

EMBO Mol Med. 2017 Aug;9(8):1088-1099. doi: 10.15252/emmm.201707561.


γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.

Ran Y, Hossain F, Pannuti A, Lessard CB, Ladd GZ, Jung JI, Minter LM, Osborne BA, Miele L, Golde TE.

EMBO Mol Med. 2017 Jul;9(7):950-966. doi: 10.15252/emmm.201607265.


Defining the minimum substrate and charge recognition model of gamma-secretase.

Yan Y, Xu TH, Melcher K, Xu HE.

Acta Pharmacol Sin. 2017 Oct;38(10):1412-1424. doi: 10.1038/aps.2017.35. Epub 2017 Apr 17.


Ferulic Acid Suppresses Amyloid β Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide.

Nagai N, Kotani S, Mano Y, Ueno A, Ito Y, Kitaba T, Takata T, Fujii N.

Biomed Res Int. 2017;2017:5343010. doi: 10.1155/2017/5343010. Epub 2017 Mar 20.


Pen-2 and Presenilin are Sufficient to Catalyze Notch Processing.

Hu C, Xu J, Zeng L, Li T, Cui MZ, Xu X.

J Alzheimers Dis. 2017;56(4):1263-1269. doi: 10.3233/JAD-161094.


Enzymatic Assays for Studying Intramembrane Proteolysis.

Bolduc DM, Selkoe DJ, Wolfe MS.

Methods Enzymol. 2017;584:295-308. doi: 10.1016/bs.mie.2016.10.026. Epub 2016 Dec 24.


Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ.

Fernandez MA, Biette KM, Dolios G, Seth D, Wang R, Wolfe MS.

Biochemistry. 2016 Oct 11;55(40):5675-5688. Epub 2016 Sep 30.


Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis.

Cui J, Wang X, Li X, Wang X, Zhang C, Li W, Zhang Y, Gu H, Xie X, Nan F, Zhao J, Pei G.

Cell Discov. 2015 Aug 18;1:15021. doi: 10.1038/celldisc.2015.21. eCollection 2015.

Supplemental Content

Support Center