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Items: 1 to 20 of 185

1.

Protein Lipidation As a Regulator of Apoptotic Calcium Release: Relevance to Cancer.

Chen JJ, Boehning D.

Front Oncol. 2017 Jun 29;7:138. doi: 10.3389/fonc.2017.00138. eCollection 2017. Review.

2.

Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations.

Wang X, Charng WL, Chen CA, Rosenfeld JA, Al Shamsi A, Al-Gazali L, McGuire M, Mew NA, Arnold GL, Qu C, Ding Y, Muzny DM, Gibbs RA, Eng CM, Walkiewicz M, Xia F, Plon SE, Lupski JR, Schaaf CP, Yang Y.

Nat Genet. 2017 Apr;49(4):613-617. doi: 10.1038/ng.3815. Epub 2017 Mar 13.

PMID:
28288113
3.

A water-mediated allosteric network governs activation of Aurora kinase A.

Cyphers S, Ruff EF, Behr JM, Chodera JD, Levinson NM.

Nat Chem Biol. 2017 Apr;13(4):402-408. doi: 10.1038/nchembio.2296. Epub 2017 Feb 6.

PMID:
28166210
4.

β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase.

Ali N, Ling N, Krishnamurthy S, Oakhill JS, Scott JW, Stapleton DI, Kemp BE, Anand GS, Gooley PR.

Sci Rep. 2016 Dec 21;6:39417. doi: 10.1038/srep39417.

5.

Imatinib binding to human c-Src is coupled to inter-domain allostery and suggests a novel kinase inhibition strategy.

Tsutsui Y, Deredge D, Wintrode PL, Hays FA.

Sci Rep. 2016 Aug 2;6:30832. doi: 10.1038/srep30832.

6.

Ensembler: Enabling High-Throughput Molecular Simulations at the Superfamily Scale.

Parton DL, Grinaway PB, Hanson SM, Beauchamp KA, Chodera JD.

PLoS Comput Biol. 2016 Jun 23;12(6):e1004728. doi: 10.1371/journal.pcbi.1004728. eCollection 2016 Jun.

7.

The Philadelphia chromosome in leukemogenesis.

Kang ZJ, Liu YF, Xu LZ, Long ZJ, Huang D, Yang Y, Liu B, Feng JX, Pan YJ, Yan JS, Liu Q.

Chin J Cancer. 2016 May 27;35:48. doi: 10.1186/s40880-016-0108-0. Review.

8.

Fatty acylation of proteins: The long and the short of it.

Resh MD.

Prog Lipid Res. 2016 Jul;63:120-31. doi: 10.1016/j.plipres.2016.05.002. Epub 2016 May 24. Review.

9.

c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution.

Badger J, Grover P, Shi H, Panjarian SB, Engen JR, Smithgall TE, Makowski L.

Biochemistry. 2016 Jun 14;55(23):3251-60. doi: 10.1021/acs.biochem.6b00202. Epub 2016 Jun 3.

10.

Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.

Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N.

PLoS Genet. 2016 Feb 29;12(2):e1005885. doi: 10.1371/journal.pgen.1005885. eCollection 2016 Feb. Erratum in: PLoS Genet. 2016 Aug;12(8):e1006265.

11.

Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway.

Chan P, Han X, Zheng B, DeRan M, Yu J, Jarugumilli GK, Deng H, Pan D, Luo X, Wu X.

Nat Chem Biol. 2016 Apr;12(4):282-9. doi: 10.1038/nchembio.2036. Epub 2016 Feb 22.

12.

SPLINTS: small-molecule protein ligand interface stabilizers.

Fischer ES, Park E, Eck MJ, Thomä NH.

Curr Opin Struct Biol. 2016 Apr;37:115-22. doi: 10.1016/j.sbi.2016.01.004. Epub 2016 Jan 30. Review.

13.

Multifunctional Abl kinases in health and disease.

Khatri A, Wang J, Pendergast AM.

J Cell Sci. 2016 Jan 1;129(1):9-16. doi: 10.1242/jcs.175521. Review.

14.

Kinase phosphorylation monitoring with i-motif DNA cross-linked SERS probes.

Ren W, Damayanti NP, Wang X, Irudayaraj JM.

Chem Commun (Camb). 2016 Jan 7;52(2):410-3. doi: 10.1039/c5cc06566f. Epub 2015 Nov 3.

15.

Angiotensin II down-regulates nephrin-Akt signaling and induces podocyte injury: roleof c-Abl.

Yang Q, Ma Y, Liu Y, Liang W, Chen X, Ren Z, Wang H, Singhal PC, Ding G.

Mol Biol Cell. 2016 Jan 1;27(1):197-208. doi: 10.1091/mbc.E15-04-0223. Epub 2015 Oct 28.

16.

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.

Lu S, Banerjee A, Jang H, Zhang J, Gaponenko V, Nussinov R.

J Biol Chem. 2015 Nov 27;290(48):28887-900. doi: 10.1074/jbc.M115.664755. Epub 2015 Oct 9.

17.

The NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex.

Sekino S, Kashiwagi Y, Kanazawa H, Takada K, Baba T, Sato S, Inoue H, Kojima M, Tani K.

Cell Commun Signal. 2015 Oct 1;13:41. doi: 10.1186/s12964-015-0119-5.

18.

Allosteric activation of apicomplexan calcium-dependent protein kinases.

Ingram JR, Knockenhauer KE, Markus BM, Mandelbaum J, Ramek A, Shan Y, Shaw DE, Schwartz TU, Ploegh HL, Lourido S.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E4975-84. doi: 10.1073/pnas.1505914112. Epub 2015 Aug 24.

19.

Fluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase Function.

Grover P, Shi H, Baumgartner M, Camacho CJ, Smithgall TE.

PLoS One. 2015 Jul 29;10(7):e0133590. doi: 10.1371/journal.pone.0133590. eCollection 2015.

20.

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase.

Klein T, Vajpai N, Phillips JJ, Davies G, Holdgate GA, Phillips C, Tucker JA, Norman RA, Scott AD, Higazi DR, Lowe D, Thompson GS, Breeze AL.

Nat Commun. 2015 Jul 23;6:7877. doi: 10.1038/ncomms8877.

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