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Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment.

Koury J, Zhong L, Hao J.

Stem Cells Int. 2017;2017:2925869. doi: 10.1155/2017/2925869. Epub 2017 Mar 5. Review.


Changes in the number of CD31-CD45-Sca-1+ cells and Shh signaling pathway involvement in the lungs of mice with emphysema and relevant effects of acute adenovirus infection.

Deng M, Li J, Gan Y, Chen Y, Chen P.

Int J Chron Obstruct Pulmon Dis. 2017 Mar 14;12:861-872. doi: 10.2147/COPD.S129871. eCollection 2017.


Association of chloride intracellular channel 4 and Indian hedgehog proteins with survival of patients with pancreatic ductal adenocarcinoma.

Zou Q, Yang Z, Li D, Liu Z, Yuan Y.

Int J Exp Pathol. 2016 Dec;97(6):422-429. doi: 10.1111/iep.12213. Epub 2017 Feb 16.


The Hedgehog Signaling Networks in Lung Cancer: The Mechanisms and Roles in Tumor Progression and Implications for Cancer Therapy.

Abe Y, Tanaka N.

Biomed Res Int. 2016;2016:7969286. doi: 10.1155/2016/7969286. Epub 2016 Dec 26. Review.


Sonidegib, a novel smoothened inhibitor for the treatment of advanced basal cell carcinoma.

Doan HQ, Silapunt S, Migden MR.

Onco Targets Ther. 2016 Sep 14;9:5671-5678. eCollection 2016. Review.


MiR-338* targeting smoothened to inhibit pulmonary fibrosis by epithelial-mesenchymal transition.

Zhuang Y, Dai J, Wang Y, Zhang H, Li X, Wang C, Cao M, Liu Y, Ding J, Cai H, Zhang D, Wang Y.

Am J Transl Res. 2016 Jul 15;8(7):3206-13. eCollection 2016.


Cancer stem cells: progress and challenges in lung cancer.

Templeton AK, Miyamoto S, Babu A, Munshi A, Ramesh R.

Stem Cell Investig. 2014 Apr 15;1:9. doi: 10.3978/j.issn.2306-9759.2014.03.06. eCollection 2014. Review.


Downregulation of leptin inhibits growth and induces apoptosis of lung cancer cells via the Notch and JAK/STAT3 signaling pathways.

Zheng XJ, Yang ZX, Dong YJ, Zhang GY, Sun MF, An XK, Pan LH, Zhang SL.

Biol Open. 2016 Jun 15;5(6):794-800. doi: 10.1242/bio.017798.


Vismodegib or cixutumumab in combination with standard chemotherapy for patients with extensive-stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E1508).

Belani CP, Dahlberg SE, Rudin CM, Fleisher M, Chen HX, Takebe N, Velasco MR Jr, Tester WJ, Sturtz K, Hann CL, Shanks JC, Monga M, Ramalingam SS, Schiller JH.

Cancer. 2016 Aug 1;122(15):2371-8. doi: 10.1002/cncr.30062. Epub 2016 May 10.


Arsenic trioxide inhibits cancer stem-like cells via down-regulation of Gli1 in lung cancer.

Chang KJ, Yang MH, Zheng JC, Li B, Nie W.

Am J Transl Res. 2016 Feb 15;8(2):1133-43. eCollection 2016.


Endogenous and Exogenous Stem/Progenitor Cells in the Lung and Their Role in the Pathogenesis and Treatment of Pediatric Lung Disease.

Leibel S, Post M.

Front Pediatr. 2016 Apr 14;4:36. doi: 10.3389/fped.2016.00036. eCollection 2016. Review.


Hedgehog pathway maintains cell survival under stress conditions, and drives drug resistance in lung adenocarcinoma.

Lin EH, Kao YR, Lin CA, Kuo TY, Yang SP, Hsu CF, Chou TY, Ho CC, Wu CW.

Oncotarget. 2016 Apr 26;7(17):24179-93. doi: 10.18632/oncotarget.8253.


Targeted drugs in small-cell lung cancer.

Santarpia M, Daffinà MG, Karachaliou N, González-Cao M, Lazzari C, Altavilla G, Rosell R.

Transl Lung Cancer Res. 2016 Feb;5(1):51-70. doi: 10.3978/j.issn.2218-6751.2016.01.12. Review.


Cancer stem cells in small cell lung cancer.

Codony-Servat J, Verlicchi A, Rosell R.

Transl Lung Cancer Res. 2016 Feb;5(1):16-25. doi: 10.3978/j.issn.2218-6751.2016.01.01. Review.


Blockade of Hedgehog Signaling Synergistically Increases Sensitivity to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cell Lines.

Bai XY, Zhang XC, Yang SQ, An SJ, Chen ZH, Su J, Xie Z, Gou LY, Wu YL.

PLoS One. 2016 Mar 4;11(3):e0149370. doi: 10.1371/journal.pone.0149370. eCollection 2016.


Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells.

Alam MM, Sohoni S, Kalainayakan SP, Garrossian M, Zhang L.

BMC Cancer. 2016 Feb 24;16:150. doi: 10.1186/s12885-016-2200-x.


Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors.

Rimkus TK, Carpenter RL, Qasem S, Chan M, Lo HW.

Cancers (Basel). 2016 Feb 15;8(2). pii: E22. doi: 10.3390/cancers8020022. Review.


Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression.

Klein C, Zwick A, Kissel S, Forster CU, Pfeifer D, Follo M, Illert AL, Decker S, Benkler T, Pahl H, Oostendorp RA, Aumann K, Duyster J, Dierks C.

J Exp Med. 2016 Feb 8;213(2):273-90. doi: 10.1084/jem.20150556. Epub 2016 Feb 1.


Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract.

Lu Y, Starkey N, Lei W, Li J, Cheng J, Folk WR, Lubahn DB.

PLoS One. 2015 Dec 28;10(12):e0145507. doi: 10.1371/journal.pone.0145507. eCollection 2015.


Distinct Characteristics of Small Cell Lung Cancer Correlate With Central or Peripheral Origin: Subtyping Based on Location and Expression of Transcription Factor TTF-1.

Miyauchi E, Motoi N, Ono H, Ninomiya H, Ohyanagi F, Nishio M, Okumura S, Ichinose M, Ishikawa Y.

Medicine (Baltimore). 2015 Dec;94(51):e2324. doi: 10.1097/MD.0000000000002324.

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