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The Adverse Effects of Triptolide on the Reproductive System of Caenorhabditis elegans: Oogenesis Impairment and Decreased Oocyte Quality.

Ruan Q, Xu Y, Xu R, Wang J, Hua Y, Wang M, Duan J.

Int J Mol Sci. 2017 Feb 21;18(2). pii: E464. doi: 10.3390/ijms18020464.


Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes.

Lu Y, Xie T, Zhang Y, Zhou F, Ruan J, Zhu W, Zhu H, Feng Z, Zhou X.

BMC Complement Altern Med. 2017 Jan 5;17(1):15. doi: 10.1186/s12906-016-1504-3.


Triptolide Upregulates Myocardial Forkhead Helix Transcription Factor p3 Expression and Attenuates Cardiac Hypertrophy.

Ding YY, Li JM, Guo FJ, Liu Y, Tong YF, Pan XC, Lu XL, Ye W, Chen XH, Zhang HG.

Front Pharmacol. 2016 Nov 30;7:471. eCollection 2016.


Triptonide Effectively Inhibits Wnt/β-Catenin Signaling via C-terminal Transactivation Domain of β-catenin.

Chinison J, Aguilar JS, Avalos A, Huang Y, Wang Z, Cameron DJ, Hao J.

Sci Rep. 2016 Sep 6;6:32779. doi: 10.1038/srep32779.


Immunosuppressive, anti-inflammatory and anti-cancer properties of triptolide: A mini review.

Ziaei S, Halaby R.

Avicenna J Phytomed. 2016 Mar-Apr;6(2):149-64. Review.


Comparison of tripterygium wilfordii multiglycosides and tacrolimus in the treatment of idiopathic membranous nephropathy: a prospective cohort study.

Liu S, Li X, Li H, Liang Q, Chen J, Chen J.

BMC Nephrol. 2015 Dec 4;16:200. doi: 10.1186/s12882-015-0199-x.


Tripterygium glycosides inhibit inflammatory mediators in the rat synovial RSC-364 cell line stimulated with interleukin-1β.

Cai A, Qi S, Su Z, Shen H, Ma W, Dai Y.

Biomed Rep. 2015 Nov;3(6):763-766. Epub 2015 Aug 4.


Protective effects of triptolide on retinal ganglion cells in a rat model of chronic glaucoma.

Yang F, Wang D, Wu L, Li Y.

Drug Des Devel Ther. 2015 Nov 16;9:6095-107. doi: 10.2147/DDDT.S92022. eCollection 2015.


Triptolide reverses the Taxol resistance of lung adenocarcinoma by inhibiting the NF-κB signaling pathway and the expression of NF-κB-regulated drug-resistant genes.

Jiang N, Dong XP, Zhang SL, You QY, Jiang XT, Zhao XG.

Mol Med Rep. 2016 Jan;13(1):153-9. doi: 10.3892/mmr.2015.4493. Epub 2015 Nov 2.


Triptolide potentiates lung cancer cells to cisplatin-induced apoptosis by selectively inhibiting the NER activity.

Wang G, Wang X, Xu X.

Biomark Res. 2015 Jul 9;3:17. doi: 10.1186/s40364-015-0043-2. eCollection 2015.


Triptolide Attenuates Podocyte Injury by Regulating Expression of miRNA-344b-3p and miRNA-30b-3p in Rats with Adriamycin-Induced Nephropathy.

Jiang CB, Wei MG, Tu Y, Zhu H, Li CQ, Jing WM, Sun W.

Evid Based Complement Alternat Med. 2015;2015:107814. doi: 10.1155/2015/107814. Epub 2015 May 20.


Efficacy and safety of Tripterygium wilfordii hook F versus acitretin in moderate to severe psoriasis vulgaris: a randomized clinical trial.

Wu C, Jin HZ, Shu D, Li F, He CX, Qiao J, Yu XL, Zhang Y, He YB, Liu TJ.

Chin Med J (Engl). 2015 Feb 20;128(4):443-9. doi: 10.4103/0366-6999.151069.


Functional regulation of phospholipase D expression in cancer and inflammation.

Kang DW, Choi KY, Min do S.

J Biol Chem. 2014 Aug 15;289(33):22575-82. doi: 10.1074/jbc.R114.569822. Epub 2014 Jul 2. Review.


Activation of Nrf2 protects against triptolide-induced hepatotoxicity.

Li J, Shen F, Guan C, Wang W, Sun X, Fu X, Huang M, Jin J, Huang Z.

PLoS One. 2014 Jul 2;9(7):e100685. doi: 10.1371/journal.pone.0100685. eCollection 2014.


Continuation of immunosuppressive treatment may be necessary in IgA nephropathy patients with remission of proteinuria: Evaluation by repeat renal biopsy.

Luo MN, Yao CW, Xu BH, Xu YZ, Liu WJ, Feng YM, Tao JL, Liu HF.

Exp Ther Med. 2014 Mar;7(3):553-559. Epub 2013 Dec 31.


Role of NADPH oxidase-mediated reactive oxygen species in podocyte injury.

Chen S, Meng XF, Zhang C.

Biomed Res Int. 2013;2013:839761. doi: 10.1155/2013/839761. Epub 2013 Nov 11. Review.


Molecular imaging in traditional Chinese medicine therapy for neurological diseases.

Wang Z, Wan H, Li J, Zhang H, Tian M.

Biomed Res Int. 2013;2013:608430. doi: 10.1155/2013/608430. Epub 2013 Oct 7. Review.


Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1.

Banerjee S, Sangwan V, McGinn O, Chugh R, Dudeja V, Vickers SM, Saluja AK.

J Biol Chem. 2013 Nov 22;288(47):33927-38. doi: 10.1074/jbc.M113.500983. Epub 2013 Oct 15.


Triptolide induces lysosomal-mediated programmed cell death in MCF-7 breast cancer cells.

Owa C, Messina ME Jr, Halaby R.

Int J Womens Health. 2013 Sep 5;5:557-69. doi: 10.2147/IJWH.S44074. eCollection 2013.


Triptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis.

Ben Yebdri F, Van Grevenynghe J, Tang VA, Goulet ML, Wu JH, Stojdl DF, Hiscott J, Lin R.

Mol Ther. 2013 Nov;21(11):2043-53. doi: 10.1038/mt.2013.187. Epub 2013 Aug 28.

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