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Items: 1 to 20 of 47


Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation.

Suleymanova N, Crudden C, Worrall C, Dricu A, Girnita A, Girnita L.

Oncotarget. 2017 Jul 17;8(47):82256-82267. doi: 10.18632/oncotarget.19286. eCollection 2017 Oct 10.


Drug delivery approaches for breast cancer.

Singh SK, Singh S, Lillard JW Jr, Singh R.

Int J Nanomedicine. 2017 Aug 24;12:6205-6218. doi: 10.2147/IJN.S140325. eCollection 2017. Review.


Understanding the Key to Targeting the IGF Axis in Cancer: A Biomarker Assessment.

Lodhia KA, Tienchaiananda P, Haluska P.

Front Oncol. 2015 Jul 8;5:142. doi: 10.3389/fonc.2015.00142. eCollection 2015. Review.


IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas.

Huang X, Park H, Greene J, Pao J, Mulvey E, Zhou SX, Albert CM, Moy F, Sachdev D, Yee D, Rader C, Hamby CV, Loeb DM, Cairo MS, Zhou X.

PLoS One. 2015 Jul 14;10(7):e0133152. doi: 10.1371/journal.pone.0133152. eCollection 2015.


GSK1838705A, an insulin-like growth factor-1 receptor/insulin receptor inhibitor, induces apoptosis and reduces viability of docetaxel-resistant prostate cancer cells both in vitro and in vivo.

Zhou F, Chen X, Fan S, Tai S, Jiang C, Zhang Y, Hao Z, Zhou J, Shi H, Zhang L, Liang C.

Onco Targets Ther. 2015 Apr 10;8:753-60. doi: 10.2147/OTT.S79105. eCollection 2015.


IGF-IR Targeted Therapy: Past, Present and Future.

Janssen JA, Varewijck AJ.

Front Endocrinol (Lausanne). 2014 Dec 23;5:224. doi: 10.3389/fendo.2014.00224. eCollection 2014. Review.


Can we unlock the potential of IGF-1R inhibition in cancer therapy?

King H, Aleksic T, Haluska P, Macaulay VM.

Cancer Treat Rev. 2014 Oct;40(9):1096-105. doi: 10.1016/j.ctrv.2014.07.004. Epub 2014 Aug 4. Review.


Phloroglucinol induces apoptosis through the regulation of insulin-like growth factor 1 receptor signaling pathways in human colon cancer HT-29 cells.

Kang MH, Kim IH, Nam TJ.

Int J Oncol. 2014 Sep;45(3):1036-42. doi: 10.3892/ijo.2014.2521. Epub 2014 Jun 24.


Progesterone receptor-B enhances estrogen responsiveness of breast cancer cells via scaffolding PELP1- and estrogen receptor-containing transcription complexes.

Daniel AR, Gaviglio AL, Knutson TP, Ostrander JH, D'Assoro AB, Ravindranathan P, Peng Y, Raj GV, Yee D, Lange CA.

Oncogene. 2015 Jan 22;34(4):506-15. doi: 10.1038/onc.2013.579. Epub 2014 Jan 27.


Targeting non-small cell lung cancer cells by dual inhibition of the insulin receptor and the insulin-like growth factor-1 receptor.

Vincent EE, Elder DJ, Curwen J, Kilgour E, Hers I, Tavaré JM.

PLoS One. 2013 Jun 24;8(6):e66963. doi: 10.1371/journal.pone.0066963. Print 2013.


IGF-1 receptor is down-regulated by sunitinib induces MDM2-dependent ubiquitination.

Shen H, Fang Y, Dong W, Mu X, Liu Q, Du J.

FEBS Open Bio. 2011 Dec 27;2:1-5. doi: 10.1016/j.fob.2011.12.001. Print 2012.


Targeting insulin and insulin-like growth factor signaling in breast cancer.

Yang Y, Yee D.

J Mammary Gland Biol Neoplasia. 2012 Dec;17(3-4):251-61. doi: 10.1007/s10911-012-9268-y. Epub 2012 Oct 10. Review.


Evaluation of a novel hexavalent humanized anti-IGF-1R antibody and its bivalent parental IgG in diverse cancer cell lines.

Chang CH, Wang Y, Trisal P, Li R, Rossi DL, Nair A, Gupta P, Losman M, Cardillo TM, Rossi EA, Goldenberg DM.

PLoS One. 2012;7(8):e44235. doi: 10.1371/journal.pone.0044235. Epub 2012 Aug 31.


Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.

Marconett CN, Singhal AK, Sundar SN, Firestone GL.

Mol Cell Endocrinol. 2012 Nov 5;363(1-2):74-84. doi: 10.1016/j.mce.2012.07.008. Epub 2012 Jul 24.


Insulin-like growth factor receptor inhibitors: baby or the bathwater?

Yee D.

J Natl Cancer Inst. 2012 Jul 3;104(13):975-81. doi: 10.1093/jnci/djs258. Epub 2012 Jul 3. Review.


Acquired resistance to tamoxifen is associated with loss of the type I insulin-like growth factor receptor: implications for breast cancer treatment.

Fagan DH, Uselman RR, Sachdev D, Yee D.

Cancer Res. 2012 Jul 1;72(13):3372-80. doi: 10.1158/0008-5472.CAN-12-0684. Epub 2012 May 9.


Potent inhibition of angiogenesis by the IGF-1 receptor-targeting antibody SCH717454 is reversed by IGF-2.

Bid HK, Zhan J, Phelps DA, Kurmasheva RT, Houghton PJ.

Mol Cancer Ther. 2012 Mar;11(3):649-59. doi: 10.1158/1535-7163.MCT-11-0575. Epub 2011 Dec 21.


MicroRNAs link estrogen receptor alpha status and Dicer levels in breast cancer.

Cochrane DR, Cittelly DM, Howe EN, Spoelstra NS, McKinsey EL, LaPara K, Elias A, Yee D, Richer JK.

Horm Cancer. 2010 Dec;1(6):306-19. doi: 10.1007/s12672-010-0043-5.


Loss of one Tgfbr2 allele in fibroblasts promotes metastasis in MMTV: polyoma middle T transgenic and transplant mouse models of mammary tumor progression.

Fang WB, Jokar I, Chytil A, Moses HL, Abel T, Cheng N.

Clin Exp Metastasis. 2011 Apr;28(4):351-66. doi: 10.1007/s10585-011-9373-0. Epub 2011 Mar 4.


Combination of anti-IGF-1R antibody A12 and ionizing radiation in upper respiratory tract cancers.

Riesterer O, Yang Q, Raju U, Torres M, Molkentine D, Patel N, Valdecanas D, Milas L, Ang KK.

Int J Radiat Oncol Biol Phys. 2011 Mar 15;79(4):1179-87. doi: 10.1016/j.ijrobp.2010.10.003. Epub 2010 Dec 2.

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