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Items: 1 to 20 of 29


p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma.

Hideshima T, Cottini F, Nozawa Y, Seo HS, Ohguchi H, Samur MK, Cirstea D, Mimura N, Iwasawa Y, Richardson PG, Munshi NC, Chauhan D, Massefski W, Utsugi T, Dhe-Paganon S, Anderson KC.

Blood. 2017 Mar 9;129(10):1308-1319. doi: 10.1182/blood-2016-09-738500. Epub 2017 Jan 12.


Gata3 restrains B cell proliferation and cooperates with p18INK4c to repress B cell lymphomagenesis.

Liu S, Chan HL, Bai F, Ma J, Scott A, Robbins DJ, Capobianco AJ, Zhu P, Pei XH.

Oncotarget. 2016 Sep 27;7(39):64007-64020. doi: 10.18632/oncotarget.11746.


Cluster Analysis of Tumor Suppressor Genes in Canine Leukocytes Identifies Activation State.

Daly JA, Mortlock SA, Taylor RM, Williamson P.

Bioinform Biol Insights. 2016 Jul 19;9(Suppl 2):59-67. doi: 10.4137/BBI.S30523. eCollection 2015.


Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion.

Xie XQ, Yang P, Zhang Y, Zhang P, Wang L, Ding Y, Yang M, Tong Q, Cheng H, Ji Q, McGuire T, Yuan W, Cheng T, Gao Y.

Sci Rep. 2015 Dec 18;5:18115. doi: 10.1038/srep18115.


DNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18INK4C in gastric carcinogenesis.

Cui H, Zhao C, Gong P, Wang L, Wu H, Zhang K, Zhou R, Wang L, Zhang T, Zhong S, Fan H.

Sci Rep. 2015 Sep 9;5:13781. doi: 10.1038/srep13781.


Hsp90 inhibitor BIIB021 enhances triptolide-induced apoptosis of human T-cell acute lymphoblastic leukemia cells in vitro mainly by disrupting p53-MDM2 balance.

Li M, Zhang X, Zhou WJ, Chen YH, Liu H, Liu L, Yang CM, Qan WB.

Acta Pharmacol Sin. 2013 Dec;34(12):1545-53. doi: 10.1038/aps.2013.124. Epub 2013 Nov 18.


Cell cycle regulation by long non-coding RNAs.

Kitagawa M, Kitagawa K, Kotake Y, Niida H, Ohhata T.

Cell Mol Life Sci. 2013 Dec;70(24):4785-94. doi: 10.1007/s00018-013-1423-0. Epub 2013 Jul 24. Review.


Mapping of three genetic determinants of susceptibility to estrogen-induced mammary cancer within the Emca8 locus on rat chromosome 5.

Schaffer BS, Leland-Wavrin KM, Kurz SG, Colletti JA, Seiler NL, Warren CL, Shull JD.

Cancer Prev Res (Phila). 2013 Jan;6(1):59-69. doi: 10.1158/1940-6207.CAPR-12-0346-T. Epub 2012 Nov 14.


An opposite effect of the CDK inhibitor, p18(INK4c) on embryonic stem cells compared with tumor and adult stem cells.

Li Y, Pal R, Sung LY, Feng H, Miao W, Cheng SY, Tian C, Cheng T.

PLoS One. 2012;7(9):e45212. doi: 10.1371/journal.pone.0045212. Epub 2012 Sep 26.


Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.

Bäumer N, Tickenbrock L, Tschanter P, Lohmeyer L, Diederichs S, Bäumer S, Skryabin BV, Zhang F, Agrawal-Singh S, Köhler G, Berdel WE, Serve H, Koschmieder S, Müller-Tidow C.

J Biol Chem. 2011 Aug 12;286(32):28210-22. doi: 10.1074/jbc.M110.203471. Epub 2011 May 3.


Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis.

Pei XH, Bai F, Li Z, Smith MD, Whitewolf G, Jin R, Xiong Y.

Cancer Res. 2011 Apr 15;71(8):2969-77. doi: 10.1158/0008-5472.CAN-10-4300. Epub 2011 Apr 12.


INK4 Family -A promising target for 'gene-regulating chemoprevention' and 'molecular-targeting prevention' of cancer.

Matsuzaki Y, Sakai T.

Environ Health Prev Med. 2005 Mar;10(2):72-7. doi: 10.1007/BF02897996.


CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis.

Pei XH, Bai F, Smith MD, Usary J, Fan C, Pai SY, Ho IC, Perou CM, Xiong Y.

Cancer Cell. 2009 May 5;15(5):389-401. doi: 10.1016/j.ccr.2009.03.004.


Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma.

Ayrault O, Zindy F, Rehg J, Sherr CJ, Roussel MF.

Mol Cancer Res. 2009 Jan;7(1):33-40. doi: 10.1158/1541-7786.MCR-08-0369.


Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states.

Agarwal SK, Mateo CM, Marx SJ.

J Clin Endocrinol Metab. 2009 May;94(5):1826-34. doi: 10.1210/jc.2008-2083. Epub 2009 Jan 13. Erratum in: J Clin Endocrinol Metab. 2009 Jul;94(7):2674.


Conspirators in a capital crime: co-deletion of p18INK4c and p16INK4a/p14ARF/p15INK4b in glioblastoma multiforme.

Solomon DA, Kim JS, Jean W, Waldman T.

Cancer Res. 2008 Nov 1;68(21):8657-60. doi: 10.1158/0008-5472.CAN-08-2084. Review.


Deletions of CDKN2C in multiple myeloma: biological and clinical implications.

Leone PE, Walker BA, Jenner MW, Chiecchio L, Dagrada G, Protheroe RK, Johnson DC, Dickens NJ, Brito JL, Else M, Gonzalez D, Ross FM, Chen-Kiang S, Davies FE, Morgan GJ.

Clin Cancer Res. 2008 Oct 1;14(19):6033-41. doi: 10.1158/1078-0432.CCR-08-0347.


Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme.

Solomon DA, Kim JS, Jenkins S, Ressom H, Huang M, Coppa N, Mabanta L, Bigner D, Yan H, Jean W, Waldman T.

Cancer Res. 2008 Apr 15;68(8):2564-9. doi: 10.1158/0008-5472.CAN-07-6388. Epub 2008 Apr 1.


Differential gene expression of p27Kip1 and Rb knockout pituitary tumors associated with altered growth and angiogenesis.

Chien WM, Garrison K, Caufield E, Orthel J, Dill J, Fero ML.

Cell Cycle. 2007 Mar 15;6(6):750-7. Epub 2007 Mar 7.


Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.

Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM.

Cancer Cell. 2007 Mar;11(3):275-89.

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