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Items: 1 to 20 of 37

1.

A novel protein kinase inhibitor IMB-YH-8 with anti-tuberculosis activity.

Xu J, Wang JX, Zhou JM, Xu CL, Huang B, Xing Y, Wang B, Luo R, Wang YC, You XF, Lu Y, Yu LY.

Sci Rep. 2017 Jul 11;7(1):5093. doi: 10.1038/s41598-017-04108-7.

2.

Evolutionary Ancestry of Eukaryotic Protein Kinases and Choline Kinases.

Lai S, Safaei J, Pelech S.

J Biol Chem. 2016 Mar 4;291(10):5199-205. doi: 10.1074/jbc.M115.691428. Epub 2016 Jan 7.

3.

Identification and classification of small molecule kinases: insights into substrate recognition and specificity.

Oruganty K, Talevich EE, Neuwald AF, Kannan N.

BMC Evol Biol. 2016 Jan 6;16:7. doi: 10.1186/s12862-015-0576-x.

4.

Validated LC--MS/MS method for determination of YH-8, a novel PKnB inhibitor, in rat plasma and its application to pharmacokinetic study.

Zhai Q, Pang J, Li G, Li C, Yang X, Yu L, Wang Y, Li J, You X.

Acta Pharm Sin B. 2015 Sep;5(5):467-72. doi: 10.1016/j.apsb.2015.04.001. Epub 2015 May 28.

5.

Regulation of transcription by eukaryotic-like serine-threonine kinases and phosphatases in Gram-positive bacterial pathogens.

Wright DP, Ulijasz AT.

Virulence. 2014;5(8):863-85. doi: 10.4161/21505594.2014.983404. Review.

6.

Mycobacterium tuberculosis Serine/Threonine Protein Kinases.

Prisic S, Husson RN.

Microbiol Spectr. 2014 Oct;2(5). doi: 10.1128/microbiolspec.MGM2-0006-2013. Review.

7.

Protein kinase B (PknB) of Mycobacterium tuberculosis is essential for growth of the pathogen in vitro as well as for survival within the host.

Chawla Y, Upadhyay S, Khan S, Nagarajan SN, Forti F, Nandicoori VK.

J Biol Chem. 2014 May 16;289(20):13858-75. doi: 10.1074/jbc.M114.563536. Epub 2014 Apr 4.

8.

Inhibition of Mycobacterium tuberculosis PknG by non-catalytic rubredoxin domain specific modification: reaction of an electrophilic nitro-fatty acid with the Fe-S center.

Gil M, Graña M, Schopfer FJ, Wagner T, Denicola A, Freeman BA, Alzari PM, Batthyány C, Durán R.

Free Radic Biol Med. 2013 Dec;65:150-61. doi: 10.1016/j.freeradbiomed.2013.06.021. Epub 2013 Jun 20.

9.

Enhanced ranking of PknB Inhibitors using data fusion methods.

Seal A, Yogeeswari P, Sriram D; OSDD Consortium, Wild DJ.

J Cheminform. 2013 Jan 14;5(1):2. doi: 10.1186/1758-2946-5-2.

10.

Bacterial cell division regulation by Ser/Thr kinases: a structural perspective.

Ruggiero A, De Simone P, Smaldone G, Squeglia F, Berisio R.

Curr Protein Pept Sci. 2012 Dec;13(8):756-66. Review.

11.

Structure of the sensor domain of Mycobacterium tuberculosis PknH receptor kinase reveals a conserved binding cleft.

Cavazos A, Prigozhin DM, Alber T.

J Mol Biol. 2012 Sep 28;422(4):488-94. doi: 10.1016/j.jmb.2012.06.011. Epub 2012 Jun 20.

12.

Structural analysis of Staphylococcus aureus serine/threonine kinase PknB.

Rakette S, Donat S, Ohlsen K, Stehle T.

PLoS One. 2012;7(6):e39136. doi: 10.1371/journal.pone.0039136. Epub 2012 Jun 11.

13.

Mycobacterium tuberculosis protein kinase K enables growth adaptation through translation control.

Malhotra V, Okon BP, Clark-Curtiss JE.

J Bacteriol. 2012 Aug;194(16):4184-96. doi: 10.1128/JB.00585-12. Epub 2012 Jun 1.

14.

New Test System for Serine/Threonine Protein Kinase Inhibitors Screening: E. coli APHVIII/Pk25 design.

Bekker OB, Alekseeva MG, Osolodkin DI, Palyulin VA, Elizarov SM, Zefirov NS, Danilenko VN.

Acta Naturae. 2010 Jul;2(3):110-21.

15.

Aminoglycoside 2''-phosphotransferase IIIa (APH(2'')-IIIa) prefers GTP over ATP: structural templates for nucleotide recognition in the bacterial aminoglycoside-2'' kinases.

Smith CA, Toth M, Frase H, Byrnes LJ, Vakulenko SB.

J Biol Chem. 2012 Apr 13;287(16):12893-903. doi: 10.1074/jbc.M112.341206. Epub 2012 Feb 24.

16.

Reciprocal regulation of cephalosporin resistance in Enterococcus faecalis.

Kristich CJ, Little JL, Hall CL, Hoff JS.

MBio. 2011 Nov 1;2(6):e00199-11. doi: 10.1128/mBio.00199-11. Print 2011.

17.

The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization.

Mir M, Asong J, Li X, Cardot J, Boons GJ, Husson RN.

PLoS Pathog. 2011 Jul;7(7):e1002182. doi: 10.1371/journal.ppat.1002182. Epub 2011 Jul 28.

18.

Aspects of eukaryotic-like signaling in Gram-positive cocci: a focus on virulence.

Burnside K, Rajagopal L.

Future Microbiol. 2011 Jul;6(7):747-61. doi: 10.2217/fmb.11.62. Review.

19.

Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents.

Lougheed KE, Osborne SA, Saxty B, Whalley D, Chapman T, Bouloc N, Chugh J, Nott TJ, Patel D, Spivey VL, Kettleborough CA, Bryans JS, Taylor DL, Smerdon SJ, Buxton RS.

Tuberculosis (Edinb). 2011 Jul;91(4):277-86. doi: 10.1016/j.tube.2011.03.005. Epub 2011 Apr 11.

20.

Eukaryote-like serine/threonine kinases and phosphatases in bacteria.

Pereira SF, Goss L, Dworkin J.

Microbiol Mol Biol Rev. 2011 Mar;75(1):192-212. doi: 10.1128/MMBR.00042-10. Review.

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