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Items: 1 to 20 of 123


Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases.

Tjin CC, Otley KD, Baguley TD, Kurup P, Xu J, Nairn AC, Lombroso PJ, Ellman JA.

ACS Cent Sci. 2017 Dec 27;3(12):1322-1328. doi: 10.1021/acscentsci.7b00486. Epub 2017 Dec 6.


Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.

Pose-Utrilla J, García-Guerra L, Del Puerto A, Martín A, Jurado-Arjona J, De León-Reyes NS, Gamir-Morralla A, Serrano ÁS, García-Gallo M, Kremer L, Fielitz J, Ireson C, Pérez-Álvarez MJ, Ferrer I, Hernández F, Ávila J, Lasa M, Campanero MR, Iglesias T.

Nat Commun. 2017 Dec 22;8(1):2275. doi: 10.1038/s41467-017-02322-5.


X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.

Witten MR, Wissler L, Snow M, Geschwindner S, Read JA, Brandon NJ, Nairn AC, Lombroso PJ, Käck H, Ellman JA.

J Med Chem. 2017 Nov 22;60(22):9299-9319. doi: 10.1021/acs.jmedchem.7b01292. Epub 2017 Nov 8.


Molecular underpinnings of neurodegenerative disorders: striatal-enriched protein tyrosine phosphatase signaling and synaptic plasticity.

Lombroso PJ, Ogren M, Kurup P, Nairn AC.

F1000Res. 2016 Dec 29;5. pii: F1000 Faculty Rev-2932. doi: 10.12688/f1000research.8571.1. eCollection 2016. Review.


Cellular and Molecular Mechanisms of REM Sleep Homeostatic Drive: A Plausible Component for Behavioral Plasticity.

Datta S, Oliver MD.

Front Neural Circuits. 2017 Sep 14;11:63. doi: 10.3389/fncir.2017.00063. eCollection 2017.


Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP61.

Xu J, Kurup P, Nairn AC, Lombroso PJ.

Mol Neurobiol. 2017 May 2. doi: 10.1007/s12035-017-0555-x. [Epub ahead of print]


Intra-prelimbic cortical inhibition of striatal-enriched tyrosine phosphatase suppresses cocaine seeking in rats.

Siemsen BM, Lombroso PJ, McGinty JF.

Addict Biol. 2017 Mar 28. doi: 10.1111/adb.12504. [Epub ahead of print]


STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit.

Tian M, Xu J, Lei G, Lombroso PJ, Jackson MF, MacDonald JF.

Sci Rep. 2016 Nov 18;6:36684. doi: 10.1038/srep36684.


Glutamatergic neurotransmission in the prefrontal cortex mediates the suppressive effect of intra-prelimbic cortical infusion of BDNF on cocaine-seeking.

Go BS, Barry SM, McGinty JF.

Eur Neuropsychopharmacol. 2016 Dec;26(12):1989-1999. doi: 10.1016/j.euroneuro.2016.10.002. Epub 2016 Oct 17.


Role of Striatal-Enriched Tyrosine Phosphatase in Neuronal Function.

Kamceva M, Benedict J, Nairn AC, Lombroso PJ.

Neural Plast. 2016;2016:8136925. doi: 10.1155/2016/8136925. Epub 2016 Apr 12. Review.


Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic Plasticity.

Jang SS, Royston SE, Lee G, Wang S, Chung HJ.

Neural Plast. 2016;2016:2123748. doi: 10.1155/2016/2123748. Epub 2016 Apr 5.


Aging is associated with dimerization and inactivation of the brain-enriched tyrosine phosphatase STEP.

Rajagopal S, Deb I, Poddar R, Paul S.

Neurobiol Aging. 2016 May;41:25-38. doi: 10.1016/j.neurobiolaging.2016.02.004. Epub 2016 Feb 12.


Social and novel contexts modify hippocampal CA2 representations of space.

Alexander GM, Farris S, Pirone JR, Zheng C, Colgin LL, Dudek SM.

Nat Commun. 2016 Jan 25;7:10300. doi: 10.1038/ncomms10300.


Zn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION.

Poddar R, Rajagopal S, Shuttleworth CW, Paul S.

J Biol Chem. 2016 Jan 8;291(2):813-25. doi: 10.1074/jbc.M115.663468. Epub 2015 Nov 16.


Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice.

Xu J, Kurup P, Baguley TD, Foscue E, Ellman JA, Nairn AC, Lombroso PJ.

Cell Mol Life Sci. 2016 Apr;73(7):1503-14. doi: 10.1007/s00018-015-2057-1. Epub 2015 Oct 8.


Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity.

Jang SS, Royston SE, Xu J, Cavaretta JP, Vest MO, Lee KY, Lee S, Jeong HG, Lombroso PJ, Chung HJ.

Mol Brain. 2015 Sep 22;8(1):55. doi: 10.1186/s13041-015-0148-4.


Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5.

Brigidi GS, Santyr B, Shimell J, Jovellar B, Bamji SX.

Nat Commun. 2015 Sep 3;6:8200. doi: 10.1038/ncomms9200.


Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels.

Xu J, Kurup P, Azkona G, Baguley TD, Saavedra A, Nairn AC, Ellman JA, Pérez-Navarro E, Lombroso PJ.

J Neurochem. 2016 Jan;136(2):285-94. doi: 10.1111/jnc.13295. Epub 2015 Sep 17.


Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition.

Azkona G, Saavedra A, Aira Z, Aluja D, Xifró X, Baguley T, Alberch J, Ellman JA, Lombroso PJ, Azkue JJ, Pérez-Navarro E.

Pain. 2016 Feb;157(2):377-86. doi: 10.1097/j.pain.0000000000000329.

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