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Items: 1 to 20 of 90

1.

Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium.

Liu X, Vien T, Duan J, Sheu SH, DeCaen PG, Clapham DE.

Elife. 2018 Feb 14;7. pii: e33183. doi: 10.7554/eLife.33183.

2.

A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed.

Lin CC, Kurashige M, Liu Y, Terabayashi T, Ishimoto Y, Wang T, Choudhary V, Hobbs R, Liu LK, Lee PH, Outeda P, Zhou F, Restifo NP, Watnick T, Kawano H, Horie S, Prinz W, Xu H, Menezes LF, Germino GG.

Sci Rep. 2018 Feb 9;8(1):2743. doi: 10.1038/s41598-018-20856-6.

3.

Autosomal Dominant Polycystic Kidney Patients May Be Predisposed to Various Cardiomyopathies.

Chebib FT, Hogan MC, El-Zoghby ZM, Irazabal MV, Senum SR, Heyer CM, Madsen CD, Cornec-Le Gall E, Behfar A, Harris PC, Torres VE.

Kidney Int Rep. 2017 Jun 6;2(5):913-923. doi: 10.1016/j.ekir.2017.05.014. eCollection 2017 Sep.

4.

NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.

Kaimori JY, Lin CC, Outeda P, Garcia-Gonzalez MA, Menezes LF, Hartung EA, Li A, Wu G, Fujita H, Sato Y, Nakanuma Y, Yamamoto S, Ichimaru N, Takahara S, Isaka Y, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG.

Sci Rep. 2017 Aug 10;7(1):7733. doi: 10.1038/s41598-017-08284-4.

5.

Polycystin and calcium signaling in cell death and survival.

Lemos FO, Ehrlich BE.

Cell Calcium. 2018 Jan;69:37-45. doi: 10.1016/j.ceca.2017.05.011. Epub 2017 May 24. Review.

PMID:
28601384
6.

Isolated polycystic liver disease genes define effectors of polycystin-1 function.

Besse W, Dong K, Choi J, Punia S, Fedeles SV, Choi M, Gallagher AR, Huang EB, Gulati A, Knight J, Mane S, Tahvanainen E, Tahvanainen P, Sanna-Cherchi S, Lifton RP, Watnick T, Pei YP, Torres VE, Somlo S.

J Clin Invest. 2017 May 1;127(5):1772-1785. doi: 10.1172/JCI90129. Epub 2017 Apr 4.

7.

Extracellular Loops Are Essential for the Assembly and Function of Polycystin Receptor-Ion Channel Complexes.

Salehi-Najafabadi Z, Li B, Valentino V, Ng C, Martin H, Yu Y, Wang Z, Kashyap P, Yu Y.

J Biol Chem. 2017 Mar 10;292(10):4210-4221. doi: 10.1074/jbc.M116.767897. Epub 2017 Feb 2.

PMID:
28154010
8.

The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function.

Padovano V, Kuo IY, Stavola LK, Aerni HR, Flaherty BJ, Chapin HC, Ma M, Somlo S, Boletta A, Ehrlich BE, Rinehart J, Caplan MJ.

Mol Biol Cell. 2017 Jan 15;28(2):261-269. doi: 10.1091/mbc.E16-08-0597. Epub 2016 Nov 23.

9.

Bi-allelic Mutations in PKD1L1 Are Associated with Laterality Defects in Humans.

Vetrini F, D'Alessandro LC, Akdemir ZC, Braxton A, Azamian MS, Eldomery MK, Miller K, Kois C, Sack V, Shur N, Rijhsinghani A, Chandarana J, Ding Y, Holtzman J, Jhangiani SN, Muzny DM, Gibbs RA, Eng CM, Hanchard NA, Harel T, Rosenfeld JA, Belmont JW, Lupski JR, Yang Y.

Am J Hum Genet. 2016 Oct 6;99(4):886-893. doi: 10.1016/j.ajhg.2016.07.011. Epub 2016 Sep 8.

10.

Regulation of Polycystin-1 Function by Calmodulin Binding.

Doerr N, Wang Y, Kipp KR, Liu G, Benza JJ, Pletnev V, Pavlov TS, Staruschenko A, Mohieldin AM, Takahashi M, Nauli SM, Weimbs T.

PLoS One. 2016 Aug 25;11(8):e0161525. doi: 10.1371/journal.pone.0161525. eCollection 2016.

11.

Mutations in GANAB, Encoding the Glucosidase IIα Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease.

Porath B, Gainullin VG, Cornec-Le Gall E, Dillinger EK, Heyer CM, Hopp K, Edwards ME, Madsen CD, Mauritz SR, Banks CJ, Baheti S, Reddy B, Herrero JI, Bañales JM, Hogan MC, Tasic V, Watnick TJ, Chapman AB, Vigneau C, Lavainne F, Audrézet MP, Ferec C, Le Meur Y, Torres VE; Genkyst Study Group, HALT Progression of Polycystic Kidney Disease Group; Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease, Harris PC.

Am J Hum Genet. 2016 Jun 2;98(6):1193-1207. doi: 10.1016/j.ajhg.2016.05.004.

12.

Stepwise Evolution of Coral Biomineralization Revealed with Genome-Wide Proteomics and Transcriptomics.

Takeuchi T, Yamada L, Shinzato C, Sawada H, Satoh N.

PLoS One. 2016 Jun 2;11(6):e0156424. doi: 10.1371/journal.pone.0156424. eCollection 2016.

13.

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.

Pema M, Drusian L, Chiaravalli M, Castelli M, Yao Q, Ricciardi S, Somlo S, Qian F, Biffo S, Boletta A.

Nat Commun. 2016 Mar 2;7:10786. doi: 10.1038/ncomms10786.

14.
15.

Molecular evolution of candidate male reproductive genes in the brown algal model Ectocarpus.

Lipinska AP, Van Damme EJ, De Clerck O.

BMC Evol Biol. 2016 Jan 5;16:5. doi: 10.1186/s12862-015-0577-9.

16.

Polycystins and mechanotransduction: From physiology to disease.

Piperi C, Basdra EK.

World J Exp Med. 2015 Nov 20;5(4):200-5. doi: 10.5493/wjem.v5.i4.200. eCollection 2015 Nov 20.

17.

Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis.

Nigro EA, Castelli M, Boletta A.

Cells. 2015 Oct 30;4(4):687-705. doi: 10.3390/cells4040687. Review.

18.

Regulation of polycystin-1 ciliary trafficking by motifs at its C-terminus and polycystin-2 but not by cleavage at the GPS site.

Su X, Wu M, Yao G, El-Jouni W, Luo C, Tabari A, Zhou J.

J Cell Sci. 2015 Nov 15;128(22):4063-73. doi: 10.1242/jcs.160556. Epub 2015 Oct 1.

19.

Molecular pathways and therapies in autosomal-dominant polycystic kidney disease.

Saigusa T, Bell PD.

Physiology (Bethesda). 2015 May;30(3):195-207. doi: 10.1152/physiol.00032.2014. Review.

20.

Vasopressin and disruption of calcium signalling in polycystic kidney disease.

Chebib FT, Sussman CR, Wang X, Harris PC, Torres VE.

Nat Rev Nephrol. 2015 Aug;11(8):451-64. doi: 10.1038/nrneph.2015.39. Epub 2015 Apr 14. Review.

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