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Items: 1 to 20 of 37

1.

Prostaglandin I2 upregulates the expression of anterior pharynx-defective-1α and anterior pharynx-defective-1β in amyloid precursor protein/presenilin 1 transgenic mice.

Wang P, Guan PP, Guo JW, Cao LL, Xu GB, Yu X, Wang Y, Wang ZY.

Aging Cell. 2016 Oct;15(5):861-71. doi: 10.1111/acel.12495. Epub 2016 May 30.

2.

Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments.

Meckler X, Checler F.

J Biol Chem. 2016 Jun 10;291(24):12821-37. doi: 10.1074/jbc.M115.708297. Epub 2016 Apr 8.

3.

Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain.

Bolduc DM, Montagna DR, Gu Y, Selkoe DJ, Wolfe MS.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E509-18. doi: 10.1073/pnas.1512952113. Epub 2015 Dec 22.

4.

An atomic structure of human γ-secretase.

Bai XC, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SHW, Shi Y.

Nature. 2015 Sep 10;525(7568):212-217. doi: 10.1038/nature14892. Epub 2015 Aug 17.

5.

microRNA Expression Profiling of Propofol-Treated Developing Rat Hippocampal Astrocytes.

Sun W, Pei L.

DNA Cell Biol. 2015 Aug;34(8):511-23. doi: 10.1089/dna.2015.2831. Epub 2015 Jun 17.

6.

SUMO1 Affects Synaptic Function, Spine Density and Memory.

Matsuzaki S, Lee L, Knock E, Srikumar T, Sakurai M, Hazrati LN, Katayama T, Staniszewski A, Raught B, Arancio O, Fraser PE.

Sci Rep. 2015 May 29;5:10730. doi: 10.1038/srep10730.

7.

Structural basis of human γ-secretase assembly.

Sun L, Zhao L, Yang G, Yan C, Zhou R, Zhou X, Xie T, Zhao Y, Wu S, Li X, Shi Y.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6003-8. doi: 10.1073/pnas.1506242112. Epub 2015 Apr 27.

8.

Structural biology of presenilin 1 complexes.

Li Y, Bohm C, Dodd R, Chen F, Qamar S, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH.

Mol Neurodegener. 2014 Dec 18;9:59. doi: 10.1186/1750-1326-9-59. Review.

9.

Three-dimensional structure of human γ-secretase.

Lu P, Bai XC, Ma D, Xie T, Yan C, Sun L, Yang G, Zhao Y, Zhou R, Scheres SHW, Shi Y.

Nature. 2014 Aug 14;512(7513):166-170. doi: 10.1038/nature13567. Epub 2014 Jun 29.

10.

Targeting γ-secretase in breast cancer.

Han J, Shen Q.

Breast Cancer (Dove Med Press). 2012 Jun 21;4:83-90. doi: 10.2147/BCTT.S26437. Review.

11.

Signature amyloid β profiles are produced by different γ-secretase complexes.

Acx H, Chávez-Gutiérrez L, Serneels L, Lismont S, Benurwar M, Elad N, De Strooper B.

J Biol Chem. 2014 Feb 14;289(7):4346-55. doi: 10.1074/jbc.M113.530907. Epub 2013 Dec 13.

12.

Γ-secretase components as predictors of breast cancer outcome.

Peltonen HM, Haapasalo A, Hiltunen M, Kataja V, Kosma VM, Mannermaa A.

PLoS One. 2013 Nov 1;8(11):e79249. doi: 10.1371/journal.pone.0079249. eCollection 2013.

13.

Toward the structure of presenilin/γ-secretase and presenilin homologs.

Wolfe MS.

Biochim Biophys Acta. 2013 Dec;1828(12):2886-97. doi: 10.1016/j.bbamem.2013.04.015. Review.

14.

The very many faces of presenilins and the γ-secretase complex.

Smolarkiewicz M, Skrzypczak T, Wojtaszek P.

Protoplasma. 2013 Oct;250(5):997-1011. doi: 10.1007/s00709-013-0494-y. Epub 2013 Mar 16. Review.

15.

Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations.

Chami L, Buggia-Prévot V, Duplan E, Del Prete D, Chami M, Peyron JF, Checler F.

J Biol Chem. 2012 Jul 13;287(29):24573-84. doi: 10.1074/jbc.M111.333054. Epub 2012 May 31. Erratum in: J Biol Chem. 2015 Dec 11;290(50):29758. Delprete, Dolores [corrected to Del Prete, Dolores]. J Biol Chem. 2013 Jul 5;288(27):19645.

16.

Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.

De Strooper B, Iwatsubo T, Wolfe MS.

Cold Spring Harb Perspect Med. 2012 Jan;2(1):a006304. doi: 10.1101/cshperspect.a006304. Review.

17.

Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.

Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T.

J Biol Chem. 2012 Jan 6;287(2):1100-11. doi: 10.1074/jbc.M111.288258. Epub 2011 Nov 15.

18.

Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.

Gong P, Vetrivel KS, Nguyen PD, Meckler X, Cheng H, Kounnas MZ, Wagner SL, Parent AT, Thinakaran G.

J Biol Chem. 2010 Dec 3;285(49):38042-52. doi: 10.1074/jbc.M110.132613. Epub 2010 Oct 4.

19.

Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.

Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.

J Biol Chem. 2010 May 14;285(20):14920-31. doi: 10.1074/jbc.M109.038760. Epub 2010 Mar 18.

20.

Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates.

Chen AC, Guo LY, Ostaszewski BL, Selkoe DJ, LaVoie MJ.

J Biol Chem. 2010 Apr 9;285(15):11378-91. doi: 10.1074/jbc.M109.088815. Epub 2010 Feb 9.

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