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Items: 16


Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux.

Subbotina A, Ravna AW, Lysaa RA, Abagyan R, Bugno R, Sager G.

J Pharm Pharmacol. 2017 Jun;69(6):675-683. doi: 10.1111/jphp.12693. Epub 2017 Feb 17.


Emerging new uses of phosphodiesterase-5 inhibitors in cardiovascular diseases.

Kukreja RC, Salloum FN, Das A, Koka S, Ockaili RA, Xi L.

Exp Clin Cardiol. 2011 Winter;16(4):e30-5.


Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study.

Cadirci E, Halici Z, Odabasoglu F, Albayrak A, Karakus E, Unal D, Atalay F, Ferah I, Unal B.

Clin Exp Immunol. 2011 Dec;166(3):374-84. doi: 10.1111/j.1365-2249.2011.04483.x.


Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors.

Temkitthawon P, Hinds TR, Beavo JA, Viyoch J, Suwanborirux K, Pongamornkul W, Sawasdee P, Ingkaninan K.

J Ethnopharmacol. 2011 Oct 11;137(3):1437-41. doi: 10.1016/j.jep.2011.08.025. Epub 2011 Aug 30.


Erectogenic Effects of Clerodendron capitatum: Involvement of Phosphodiesterase Type-5 Inhibition.

Abdelwahab SI, Mohamed AH, Mohamed OY, Oall M, Taha MM, Mohan S, Noordin MI, Mustafa MR, Alkharfy KM.

Evid Based Complement Alternat Med. 2012;2012:137386. doi: 10.1155/2012/137386. Epub 2011 Jun 13.


Modulation of penile erection in rabbits by Mondia whitei: possible mechanism of action.

Quasie O, Martey ON, Nyarko AK, Gbewonyo WS, Okine LK.

Afr J Tradit Complement Altern Med. 2010 Apr 3;7(3):241-52.


A novel access to arylated and heteroarylated beta-carboline based PDE5 inhibitors.

Ahmed NS, Gary BD, Piazza GA, Tinsley HN, Laufer S, Abadi AH.

Med Chem. 2010 Nov;6(6):374-87.


Signalling pathways involved in sildenafil-induced relaxation of human bladder dome smooth muscle.

Oger S, Behr-Roussel D, Gorny D, Lebret T, Validire P, Cathelineau X, Alexandre L, Giuliano F.

Br J Pharmacol. 2010 Jul;160(5):1135-43. doi: 10.1111/j.1476-5381.2010.00748.x.


Effects of sildenafil on maternal hemodynamics and fetal growth in normal rat pregnancy.

Sasser JM, Baylis C.

Am J Physiol Regul Integr Comp Physiol. 2010 Feb;298(2):R433-8. doi: 10.1152/ajpregu.00198.2009. Epub 2009 Dec 2.


Phosphodiesterase-5A and neutral endopeptidase activities in human adipocytes do not control atrial natriuretic peptide-mediated lipolysis.

Moro C, Klimcakova E, Lafontan M, Berlan M, Galitzky J.

Br J Pharmacol. 2007 Dec;152(7):1102-10. Epub 2007 Oct 1.


Blockade of phosphodiesterase Type 5 enhances rat neurohypophysial excitability and electrically evoked oxytocin release.

Zhang Z, Klyachko V, Jackson MB.

J Physiol. 2007 Oct 1;584(Pt 1):137-47. Epub 2007 Aug 9.


Inhibitors of phosphodiesterase 5 (PDE 5) inhibit the nerve-induced release of nitric oxide from the rabbit corpus cavernosum.

Hallén K, Wiklund NP, Gustafsson LE.

Br J Pharmacol. 2007 Feb;150(3):353-60. Epub 2006 Dec 18.


The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma.

Clayton RA, Dick CA, Mackenzie A, Nagasawa M, Galbraith D, Hastings SF, MacKenzie SJ.

Respir Res. 2004 May 5;5:4.


Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene.

Johnston LA, Erdogan S, Cheung YF, Sullivan M, Barber R, Lynch MJ, Baillie GS, Van Heeke G, Adams DR, Huston E, Houslay MD.

Biochem J. 2004 Jun 1;380(Pt 2):371-84.

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