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Items: 1 to 20 of 27


Identification of the PAK4 interactome reveals PAK4 phosphorylation of N-WASP and promotion of Arp2/3-dependent actin polymerization.

Zhao M, Spiess M, Johansson HJ, Olofsson H, Hu J, Lehtiö J, Strömblad S.

Oncotarget. 2017 Aug 18;8(44):77061-77074. doi: 10.18632/oncotarget.20352. eCollection 2017 Sep 29.


A novel interaction of PAK4 with PPARγ to regulate Nox1 and radiation-induced epithelial-to-mesenchymal transition in glioma.

Kesanakurti D, Maddirela D, Banasavadi-Siddegowda YK, Lai TH, Qamri Z, Jacob NK, Sampath D, Mohanam S, Kaur B, Puduvalli VK.

Oncogene. 2017 Sep 14;36(37):5309-5320. doi: 10.1038/onc.2016.261. Epub 2017 May 22.


Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling.

He LF, Xu HW, Chen M, Xian ZR, Wen XF, Chen MN, Du CW, Huang WH, Wu JD, Zhang GJ.

Oncotarget. 2017 Mar 14;8(11):17573-17585. doi: 10.18632/oncotarget.7466.


P21-activated kinase 4 involves TSH induced papillary thyroid cancer cell proliferation.

Xie X, Shi X, Guan H, Guo Q, Fan C, Dong W, Wang G, Li F, Shan Z, Cao L, Teng W.

Oncotarget. 2017 Apr 11;8(15):24882-24891. doi: 10.18632/oncotarget.15079.


microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements.

Schwickert A, Weghake E, Brüggemann K, Engbers A, Brinkmann BF, Kemper B, Seggewiß J, Stock C, Ebnet K, Kiesel L, Riethmüller C, Götte M.

PLoS One. 2015 Dec 10;10(12):e0143993. doi: 10.1371/journal.pone.0143993. eCollection 2015.


p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells.

Zhuang T, Zhu J, Li Z, Lorent J, Zhao C, Dahlman-Wright K, Strömblad S.

Oncotarget. 2015 Dec 22;6(41):43853-68. doi: 10.18632/oncotarget.6081.


The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity.

Selamat W, Tay PL, Baskaran Y, Manser E.

PLoS One. 2015 Jun 11;10(6):e0129634. doi: 10.1371/journal.pone.0129634. eCollection 2015.


Signaling, Regulation, and Specificity of the Type II p21-activated Kinases.

Ha BH, Morse EM, Turk BE, Boggon TJ.

J Biol Chem. 2015 May 22;290(21):12975-83. doi: 10.1074/jbc.R115.650416. Epub 2015 Apr 8. Review.


Phosphorylation of tyrosine 285 of PAK1 facilitates βPIX/GIT1 binding and adhesion turnover.

Hammer A, Oladimeji P, De Las Casas LE, Diakonova M.

FASEB J. 2015 Mar;29(3):943-59. doi: 10.1096/fj.14-259366. Epub 2014 Dec 2.


Republished: tracing PAKs from GI inflammation to cancer.

Dammann K, Khare V, Gasche C.

Postgrad Med J. 2014 Nov;90(1069):657-68. doi: 10.1136/postgradmedj-2014-306768rep.


Network Based Prediction Model for Genomics Data Analysis.

Huang Y, Wang P.

Stat Biosci. 2012 Apr 1;4(1). doi: 10.1007/s12561-012-9056-7.


Rho GTPases and regulation of cell migration and polarization in human corneal epithelial cells.

Hou A, Toh LX, Gan KH, Lee KJ, Manser E, Tong L.

PLoS One. 2013 Oct 10;8(10):e77107. doi: 10.1371/journal.pone.0077107. eCollection 2013.


Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma.

Kesanakurti D, Chetty C, Rajasekhar Maddirela D, Gujrati M, Rao JS.

Cell Death Dis. 2012 Dec 20;3:e445. doi: 10.1038/cddis.2012.182.


miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration.

Amelio I, Lena AM, Viticchiè G, Shalom-Feuerstein R, Terrinoni A, Dinsdale D, Russo G, Fortunato C, Bonanno E, Spagnoli LG, Aberdam D, Knight RA, Candi E, Melino G.

J Cell Biol. 2012 Oct 15;199(2):347-63. doi: 10.1083/jcb.201203134.


Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.

Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16107-12. doi: 10.1073/pnas.1214447109. Epub 2012 Sep 17.


Integrin β5 contributes to the tumorigenic potential of breast cancer cells through the Src-FAK and MEK-ERK signaling pathways.

Bianchi-Smiraglia A, Paesante S, Bakin AV.

Oncogene. 2013 Jun 20;32(25):3049-58. doi: 10.1038/onc.2012.320. Epub 2012 Jul 23.


The matrix protein CCN1/CYR61 is required for α(V)β5-mediated cancer cell migration.

Jandova J, Beyer TE, Meuillet EJ, Watts GS.

Cell Biochem Funct. 2012 Dec;30(8):687-95. doi: 10.1002/cbf.2853. Epub 2012 Jun 13.


p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients.

Siu MK, Chan HY, Kong DS, Wong ES, Wong OG, Ngan HY, Tam KF, Zhang H, Li Z, Chan QK, Tsao SW, Strömblad S, Cheung AN.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18622-7. doi: 10.1073/pnas.0907481107. Epub 2010 Oct 6.


Integrin-mediated cell attachment induces a PAK4-dependent feedback loop regulating cell adhesion through modified integrin alpha v beta 5 clustering and turnover.

Li Z, Lock JG, Olofsson H, Kowalewski JM, Teller S, Liu Y, Zhang H, Strömblad S.

Mol Biol Cell. 2010 Oct 1;21(19):3317-29. doi: 10.1091/mbc.E10-03-0245. Epub 2010 Aug 18.


p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration.

Li Z, Zhang H, Lundin L, Thullberg M, Liu Y, Wang Y, Claesson-Welsh L, Strömblad S.

J Biol Chem. 2010 Jul 30;285(31):23699-710. doi: 10.1074/jbc.M110.123497. Epub 2010 May 27.

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