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Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathways.

Kim JY, Lee HJ, Lee SJ, Jung YH, Yoo DY, Hwang IK, Seong JK, Ryu JM, Han HJ.

Sci Rep. 2017 Jun 28;7(1):4335. doi: 10.1038/s41598-017-04175-w.


The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review).

Ardito F, Giuliani M, Perrone D, Troiano G, Lo Muzio L.

Int J Mol Med. 2017 Aug;40(2):271-280. doi: 10.3892/ijmm.2017.3036. Epub 2017 Jun 22.


Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis.

Reiter RJ, Rosales-Corral SA, Tan DX, Acuna-Castroviejo D, Qin L, Yang SF, Xu K.

Int J Mol Sci. 2017 Apr 17;18(4). pii: E843. doi: 10.3390/ijms18040843. Review.


The hypoxia signalling pathway in haematological malignancies.

Irigoyen M, García-Ruiz JC, Berra E.

Oncotarget. 2017 May 30;8(22):36832-36844. doi: 10.18632/oncotarget.15981. Review.


mTOR function and therapeutic targeting in breast cancer.

Hare SH, Harvey AJ.

Am J Cancer Res. 2017 Mar 1;7(3):383-404. eCollection 2017. Review.


Hypoxic preconditioning of human cardiosphere-derived cell sheets enhances cellular functions via activation of the PI3K/Akt/mTOR/HIF-1α pathway.

Tanaka Y, Hosoyama T, Mikamo A, Kurazumi H, Nishimoto A, Ueno K, Shirasawa B, Hamano K.

Am J Transl Res. 2017 Feb 15;9(2):664-673. eCollection 2017.


The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia.

Di Conza G, Trusso Cafarello S, Loroch S, Mennerich D, Deschoemaeker S, Di Matteo M, Ehling M, Gevaert K, Prenen H, Zahedi RP, Sickmann A, Kietzmann T, Moretti F, Mazzone M.

Cell Rep. 2017 Feb 14;18(7):1699-1712. doi: 10.1016/j.celrep.2017.01.051.


Mammalian target of rapamycin (mTOR): a central regulator of male fertility?

Jesus TT, Oliveira PF, Sousa M, Cheng CY, Alves MG.

Crit Rev Biochem Mol Biol. 2017 Jun;52(3):235-253. doi: 10.1080/10409238.2017.1279120. Epub 2017 Jan 26. Review.


Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer.

Ata R, Antonescu CN.

Int J Mol Sci. 2017 Jan 18;18(1). pii: E189. doi: 10.3390/ijms18010189. Review.


Metabolic reprogramming and tolerance during sepsis-induced AKI.

Gómez H, Kellum JA, Ronco C.

Nat Rev Nephrol. 2017 Mar;13(3):143-151. doi: 10.1038/nrneph.2016.186. Epub 2017 Jan 16. Review.


Hypoxia Regulates mTORC1-Mediated Keratinocyte Motility and Migration via the AMPK Pathway.

Yan T, Zhang J, Tang D, Zhang X, Jiang X, Zhao L, Zhang Q, Zhang D, Huang Y.

PLoS One. 2017 Jan 9;12(1):e0169155. doi: 10.1371/journal.pone.0169155. eCollection 2017.


Multistep regulation of TFEB by MTORC1.

Vega-Rubin-de-Celis S, Peña-Llopis S, Konda M, Brugarolas J.

Autophagy. 2017 Mar 4;13(3):464-472. doi: 10.1080/15548627.2016.1271514. Epub 2017 Jan 5.


Predictive and prognostic biomarkers of targeted agents and modern immunotherapy in renal cell carcinoma.

Rodriguez-Vida A, Strijbos M, Hutson T.

ESMO Open. 2016 May 25;1(3):e000013. eCollection 2016. Review.


Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives.

Ong PS, Wang LZ, Dai X, Tseng SH, Loo SJ, Sethi G.

Front Pharmacol. 2016 Oct 25;7:395. eCollection 2016. Review.


Everolimus (RAD001) sensitizes prostate cancer cells to docetaxel by down-regulation of HIF-1α and sphingosine kinase 1.

Alshaker H, Wang Q, Kawano Y, Arafat T, Böhler T, Winkler M, Cooper C, Pchejetski D.

Oncotarget. 2016 Dec 6;7(49):80943-80956. doi: 10.18632/oncotarget.13115.


mTORC1 and mTORC2 in cancer and the tumor microenvironment.

Kim LC, Cook RS, Chen J.

Oncogene. 2017 Apr 20;36(16):2191-2201. doi: 10.1038/onc.2016.363. Epub 2016 Oct 17. Review.


Nutrients and the microenvironment to feed a T cell army.

Johnson MO, Siska PJ, Contreras DC, Rathmell JC.

Semin Immunol. 2016 Oct;28(5):505-513. doi: 10.1016/j.smim.2016.09.003. Epub 2016 Oct 3. Review.


Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner.

Daijo H, Hoshino Y, Kai S, Suzuki K, Nishi K, Matsuo Y, Harada H, Hirota K.

Sci Rep. 2016 Sep 29;6:34424. doi: 10.1038/srep34424.


Diacetoxyscirpenol as a new anticancer agent to target hypoxia-inducible factor 1.

Choi YJ, Shin HW, Chun YS, Leutou AS, Son BW, Park JW.

Oncotarget. 2016 Sep 20;7(38):62107-62122. doi: 10.18632/oncotarget.11529.


The mTOR/AP-1/VEGF signaling pathway regulates vascular endothelial cell growth.

Wang S, Lu J, You Q, Huang H, Chen Y, Liu K.

Oncotarget. 2016 Aug 16;7(33):53269-53276. doi: 10.18632/oncotarget.10756.

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