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Items: 1 to 20 of 189

1.

Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes.

Tran TQ, Ishak Gabra MB, Lowman XH, Yang Y, Reid MA, Pan M, O'Connor TR, Kong M.

PLoS Biol. 2017 Nov 6;15(11):e2002810. doi: 10.1371/journal.pbio.2002810. eCollection 2017 Nov.

2.

A real-time PCR-based quantitative assay for 3-methylcytosine demethylase activity of ALKBH3.

Ueda Y, Kitae K, Ooshio I, Fusamae Y, Kawaguchi M, Jingushi K, Harada K, Hirata K, Tsujikawa K.

Biochem Biophys Rep. 2016 Feb 10;5:476-481. doi: 10.1016/j.bbrep.2016.02.007. eCollection 2016 Mar.

3.

Ancestor of land plants acquired the DNA-3-methyladenine glycosylase (MAG) gene from bacteria through horizontal gene transfer.

Fang H, Huangfu L, Chen R, Li P, Xu S, Zhang E, Cao W, Liu L, Yao Y, Liang G, Xu C, Zhou Y, Yang Z.

Sci Rep. 2017 Aug 24;7(1):9324. doi: 10.1038/s41598-017-05066-w.

4.

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO.

Toh JDW, Sun L, Lau LZM, Tan J, Low JJA, Tang CWQ, Cheong EJY, Tan MJH, Chen Y, Hong W, Gao YG, Woon ECY.

Chem Sci. 2015 Jan 1;6(1):112-122. doi: 10.1039/c4sc02554g. Epub 2014 Sep 22.

5.

Insights into Watson-Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A.

Sathyamoorthy B, Shi H, Zhou H, Xue Y, Rangadurai A, Merriman DK, Al-Hashimi HM.

Nucleic Acids Res. 2017 May 19;45(9):5586-5601. doi: 10.1093/nar/gkx186.

6.

Oxidative DNA damage & repair: An introduction.

Cadet J, Davies KJA.

Free Radic Biol Med. 2017 Jun;107:2-12. doi: 10.1016/j.freeradbiomed.2017.03.030. Epub 2017 Mar 28. Review.

PMID:
28363603
7.

Biochemical Characterization of AP Lyase and m6A Demethylase Activities of Human AlkB Homologue 1 (ALKBH1).

Müller TA, Tobar MA, Perian MN, Hausinger RP.

Biochemistry. 2017 Apr 4;56(13):1899-1910. doi: 10.1021/acs.biochem.7b00060. Epub 2017 Mar 21.

PMID:
28290676
8.

Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-ι.

Jain R, Choudhury JR, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK.

Sci Rep. 2017 Mar 8;7:43904. doi: 10.1038/srep43904.

9.

Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions.

Chen F, Bian K, Tang Q, Fedeles BI, Singh V, Humulock ZT, Essigmann JM, Li D.

Chem Res Toxicol. 2017 Apr 17;30(4):1102-1110. doi: 10.1021/acs.chemrestox.7b00009. Epub 2017 Mar 24.

10.

ALKBH7 Variant Related to Prostate Cancer Exhibits Altered Substrate Binding.

Walker AR, Silvestrov P, Müller TA, Podolsky RH, Dyson G, Hausinger RP, Cisneros GA.

PLoS Comput Biol. 2017 Feb 23;13(2):e1005345. doi: 10.1371/journal.pcbi.1005345. eCollection 2017 Feb.

11.

AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells.

Ueda Y, Ooshio I, Fusamae Y, Kitae K, Kawaguchi M, Jingushi K, Hase H, Harada K, Hirata K, Tsujikawa K.

Sci Rep. 2017 Feb 13;7:42271. doi: 10.1038/srep42271.

12.

The mechanism of a formaldehyde-sensing transcriptional regulator.

Denby KJ, Iwig J, Bisson C, Westwood J, Rolfe MD, Sedelnikova SE, Higgins K, Maroney MJ, Baker PJ, Chivers PT, Green J.

Sci Rep. 2016 Dec 9;6:38879. doi: 10.1038/srep38879.

13.

N6-Methyladenine: A Conserved and Dynamic DNA Mark.

O'Brown ZK, Greer EL.

Adv Exp Med Biol. 2016;945:213-246. Review.

14.

Regulation of DNA Alkylation Damage Repair: Lessons and Therapeutic Opportunities.

Soll JM, Sobol RW, Mosammaparast N.

Trends Biochem Sci. 2017 Mar;42(3):206-218. doi: 10.1016/j.tibs.2016.10.001. Epub 2016 Nov 2. Review.

PMID:
27816326
15.

ALKBH1-Mediated tRNA Demethylation Regulates Translation.

Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C.

Cell. 2016 Oct 20;167(3):816-828.e16. doi: 10.1016/j.cell.2016.09.038. Epub 2016 Oct 13.

16.

The Effectors and Sensory Sites of Formaldehyde-responsive Regulator FrmR and Metal-sensing Variant.

Osman D, Piergentili C, Chen J, Sayer LN, Usón I, Huggins TG, Robinson NJ, Pohl E.

J Biol Chem. 2016 Sep 9;291(37):19502-16. doi: 10.1074/jbc.M116.745174. Epub 2016 Jul 29.

17.

RecA stimulates AlkB-mediated direct repair of DNA adducts.

Shivange G, Monisha M, Nigam R, Kodipelli N, Anindya R.

Nucleic Acids Res. 2016 Oct 14;44(18):8754-8763. Epub 2016 Jul 4.

18.

ALKBHs-facilitated RNA modifications and de-modifications.

A Alemu E, He C, Klungland A.

DNA Repair (Amst). 2016 Aug;44:87-91. doi: 10.1016/j.dnarep.2016.05.026. Epub 2016 May 17. Review.

19.

Base pairing and structural insights into the 5-formylcytosine in RNA duplex.

Wang R, Luo Z, He K, Delaney MO, Chen D, Sheng J.

Nucleic Acids Res. 2016 Jun 2;44(10):4968-77. doi: 10.1093/nar/gkw235. Epub 2016 Apr 13.

20.

Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage.

Li Q, Huang Y, Liu X, Gan J, Chen H, Yang CG.

J Biol Chem. 2016 May 20;291(21):11083-93. doi: 10.1074/jbc.M115.711895. Epub 2016 Mar 25.

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