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Aldosterone regulates a 5' variant sgk1 transcript via a shared hormone response element in the sgk1 5' regulatory region.

Raikwar NS, Thomas CP.

Physiol Rep. 2017 Apr;5(7). pii: e13221. doi: 10.14814/phy2.13221.


Selective glucocorticoid receptor-activating adjuvant therapy in cancer treatments.

Sundahl N, Clarisse D, Bracke M, Offner F, Berghe WV, Beck IM.

Oncoscience. 2016 Jul 27;3(7-8):188-202. eCollection 2016. Review.


Dexamethasone and insulin activate serum and glucocorticoid-inducible kinase 1 (SGK1) via different molecular mechanisms in cortical collecting duct cells.

Mansley MK, Watt GB, Francis SL, Walker DJ, Land SC, Bailey MA, Wilson SM.

Physiol Rep. 2016 May;4(10). pii: e12792. doi: 10.14814/phy2.12792.


SGK Kinase Activity in Multiple Myeloma Cells Protects against ER Stress Apoptosis via a SEK-Dependent Mechanism.

Hoang B, Shi Y, Frost PJ, Mysore V, Bardeleben C, Lichtenstein A.

Mol Cancer Res. 2016 Apr;14(4):397-407. doi: 10.1158/1541-7786.MCR-15-0422. Epub 2016 Feb 11.


Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.

Burgon J, Robertson AL, Sadiku P, Wang X, Hooper-Greenhill E, Prince LR, Walker P, Hoggett EE, Ward JR, Farrow SN, Zuercher WJ, Jeffrey P, Savage CO, Ingham PW, Hurlstone AF, Whyte MK, Renshaw SA.

J Immunol. 2014 Feb 15;192(4):1796-805. doi: 10.4049/jimmunol.1300087. Epub 2014 Jan 15.


Serum- and glucocorticoid-induced protein kinase 1 (SGK1) is regulated by store-operated Ca2+ entry and mediates cytoprotection against necrotic cell death.

Brickley DR, Agyeman AS, Kopp RF, Hall BA, Harbeck MC, Belova L, Volden PA, Wu W, Roe MW, Conzen SD.

J Biol Chem. 2013 Nov 8;288(45):32708-19. doi: 10.1074/jbc.M113.507210. Epub 2013 Sep 16.


Glucocorticoid receptor antagonism as a novel therapy for triple-negative breast cancer.

Skor MN, Wonder EL, Kocherginsky M, Goyal A, Hall BA, Cai Y, Conzen SD.

Clin Cancer Res. 2013 Nov 15;19(22):6163-72. doi: 10.1158/1078-0432.CCR-12-3826. Epub 2013 Sep 9.


Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.

Sommer EM, Dry H, Cross D, Guichard S, Davies BR, Alessi DR.

Biochem J. 2013 Jun 15;452(3):499-508. doi: 10.1042/BJ20130342.


A regulated NH2-terminal Sgk1 variant with enhanced function is expressed in the collecting duct.

Raikwar NS, Liu KZ, Thomas CP.

Am J Physiol Renal Physiol. 2012 Dec 1;303(11):F1527-33. doi: 10.1152/ajprenal.00191.2012. Epub 2012 Oct 3.


Determination of SGK1 mRNA in non-small cell lung cancer samples underlines high expression in squamous cell carcinomas.

Abbruzzese C, Mattarocci S, Pizzuti L, Mileo AM, Visca P, Antoniani B, Alessandrini G, Facciolo F, Amato R, D'Antona L, Rinaldi M, Felsani A, Perrotti N, Paggi MG.

J Exp Clin Cancer Res. 2012 Jan 12;31:4. doi: 10.1186/1756-9966-31-4.


Unique gene expression profile associated with an early-onset multiple endocrine neoplasia (MEN1)-associated pituitary adenoma.

Farrell WE, Azevedo MF, Batista DL, Smith A, Bourdeau I, Horvath A, Boguszewski M, Quezado M, Stratakis CA.

J Clin Endocrinol Metab. 2011 Nov;96(11):E1905-14. doi: 10.1210/jc.2011-1127. Epub 2011 Sep 14.


Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1.

Thomas SV, Kathpalia PP, Rajagopal M, Charlton C, Zhang J, Eaton DC, Helms MN, Pao AC.

J Biol Chem. 2011 Sep 16;286(37):32074-85. doi: 10.1074/jbc.M111.278283. Epub 2011 Jul 22.


Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization.

Soundararajan R, Wang J, Melters D, Pearce D.

J Biol Chem. 2010 Dec 17;285(51):39905-13. doi: 10.1074/jbc.M110.161133. Epub 2010 Oct 14.


Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.

Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W.

Mol Cell. 2010 Sep 10;39(5):797-808. doi: 10.1016/j.molcel.2010.08.016.


Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.

Heise CJ, Xu BE, Deaton SL, Cha SK, Cheng CJ, Earnest S, Sengupta S, Juang YC, Stippec S, Xu Y, Zhao Y, Huang CL, Cobb MH.

J Biol Chem. 2010 Aug 13;285(33):25161-7. doi: 10.1074/jbc.M110.103432. Epub 2010 Jun 4.


Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions.

Yang B, Kumar S.

Cell Death Differ. 2010 Jan;17(1):68-77. doi: 10.1038/cdd.2009.84. Review.


Regulation of a third conserved phosphorylation site in SGK1.

Chen W, Chen Y, Xu BE, Juang YC, Stippec S, Zhao Y, Cobb MH.

J Biol Chem. 2009 Feb 6;284(6):3453-60. doi: 10.1074/jbc.M807502200. Epub 2008 Dec 9.


An evolutionarily conserved N-terminal Sgk1 variant with enhanced stability and improved function.

Raikwar NS, Snyder PM, Thomas CP.

Am J Physiol Renal Physiol. 2008 Nov;295(5):F1440-8. doi: 10.1152/ajprenal.90239.2008. Epub 2008 Aug 27.


Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1.

Belova L, Brickley DR, Ky B, Sharma SK, Conzen SD.

J Biol Chem. 2008 Jul 4;283(27):18821-31. doi: 10.1074/jbc.M803289200. Epub 2008 May 2.

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