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Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA.

Perez M, Muñoz-Galván S, Jiménez-García MP, Marín JJ, Carnero A.

Oncotarget. 2015 Dec 1;6(38):40557-74. doi: 10.18632/oncotarget.5829.


Knocking down CDK4 mediates the elevation of let-7c suppressing cell growth in nasopharyngeal carcinoma.

Liu Z, Long X, Chao C, Yan C, Wu Q, Hua S, Zhang Y, Wu A, Fang W.

BMC Cancer. 2014 Apr 21;14:274. doi: 10.1186/1471-2407-14-274.


Skin Tumors Rb(eing) Uncovered.

Costa C, Paramio JM, Santos M.

Front Oncol. 2013 Dec 17;3:307. doi: 10.3389/fonc.2013.00307. Review.


p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia.

Saiz-Ladera C, Lara MF, Garín M, Ruiz S, Santos M, Lorz C, García-Escudero R, Martínez-Fernández M, Bravo A, Fernández-Capetillo O, Segrelles C, Paramio JM.

Oncogene. 2014 Sep 11;33(37):4599-612. doi: 10.1038/onc.2013.417.


CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.

Bisteau X, Paternot S, Colleoni B, Ecker K, Coulonval K, De Groote P, Declercq W, Hengst L, Roger PP.

PLoS Genet. 2013 May;9(5):e1003546. doi: 10.1371/journal.pgen.1003546.


CDK4: A Key Player in the Cell Cycle, Development, and Cancer.

Baker SJ, Reddy EP.

Genes Cancer. 2012 Nov;3(11-12):658-69. doi: 10.1177/1947601913478972.


Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development.

Wang X, Sistrunk C, Miliani de Marval PL, Kim Y, Rodriguez-Puebla ML.

Cell Cycle. 2012 Jan 15;11(2):335-42. doi: 10.4161/cc.11.2.18774.


Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4.

Warenius HM, Kilburn JD, Essex JW, Maurer RI, Blaydes JP, Agarwala U, Seabra LA.

Mol Cancer. 2011 Jun 13;10:72. doi: 10.1186/1476-4598-10-72.


Elevated expression of CDK4 in lung cancer.

Wu A, Wu B, Guo J, Luo W, Wu D, Yang H, Zhen Y, Yu X, Wang H, Zhou Y, Liu Z, Fang W, Yang Z.

J Transl Med. 2011 Apr 11;9:38. doi: 10.1186/1479-5876-9-38.


Comparative microarray data analysis for the expression of genes in the pathway of glioma.

Katara P, Sharma N, Sharma S, Khatri I, Kaushik A, Kaushal L, Sharma V.

Bioinformation. 2010 Jun 24;5(1):31-4.


Unexpected reduction of skin tumorigenesis on expression of cyclin-dependent kinase 6 in mouse epidermis.

Wang X, Sistrunk C, Rodriguez-Puebla ML.

Am J Pathol. 2011 Jan;178(1):345-54. doi: 10.1016/j.ajpath.2010.11.032.


Requirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C Mutation.

Reddy HK, Graña X, Dhanasekaran DN, Litvin J, Reddy EP.

Genes Cancer. 2010 Jan;1(1):69-80. doi: 10.1177/1947601909358105.


Cyclin-dependent kinase inhibitors block leukocyte adhesion and migration.

Liu L, Schwartz B, Tsubota Y, Raines E, Kiyokawa H, Yonekawa K, Harlan JM, Schnapp LM.

J Immunol. 2008 Feb 1;180(3):1808-17.


Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis.

Macias E, Kim Y, Miliani de Marval PL, Klein-Szanto A, Rodriguez-Puebla ML.

Cancer Res. 2007 Oct 15;67(20):9713-20.


Regulation of CDK4.

Bockstaele L, Coulonval K, Kooken H, Paternot S, Roger PP.

Cell Div. 2006 Nov 8;1:25.


Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene.

Oskarsson T, Essers MA, Dubois N, Offner S, Dubey C, Roger C, Metzger D, Chambon P, Hummler E, Beard P, Trumpp A.

Genes Dev. 2006 Aug 1;20(15):2024-9.


Surprising dependency for retinoblastoma protein in ras-mediated tumorigenesis.

DeGregori J.

Mol Cell Biol. 2006 Feb;26(4):1165-9. Review. No abstract available.


A novel role for integrin-linked kinase in epithelial sheet morphogenesis.

Vespa A, D'Souza SJ, Dagnino L.

Mol Biol Cell. 2005 Sep;16(9):4084-95.

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