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Amino acid and small GTPase regulation of mTORC1.

Nguyen TP, Frank AR, Jewell JL.

Cell Logist. 2017 Sep 29;7(4):e1378794. doi: 10.1080/21592799.2017.1378794. eCollection 2017. Review.


mTOR-Dependent Cell Proliferation in the Brain.

Ryskalin L, Lazzeri G, Flaibani M, Biagioni F, Gambardella S, Frati A, Fornai F.

Biomed Res Int. 2017;2017:7082696. doi: 10.1155/2017/7082696. Epub 2017 Nov 13. Review.


Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.

Yang H, Jiang X, Li B, Yang HJ, Miller M, Yang A, Dhar A, Pavletich NP.

Nature. 2017 Dec 21;552(7685):368-373. doi: 10.1038/nature25023. Epub 2017 Dec 13.


Codon bias among synonymous rare variants is associated with Alzheimer's disease imaging biomarker.

Miller JE, Shivakumar MK, Risacher SL, Saykin AJ, Lee S, Nho K, Kim D.

Pac Symp Biocomput. 2018;23:365-376.


A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice.

Tang F, Zhang P, Ye P, Lazarski CA, Wu Q, Bergin IL, Bender TP, Hall MN, Cui Y, Zhang L, Jiang T, Liu Y, Zheng P.

Elife. 2017 Dec 5;6. pii: e32497. doi: 10.7554/eLife.32497.


Conceptualizing Eukaryotic Metabolic Sensing and Signaling.

Laxman S.

J Indian Inst Sci. 2017 Mar;97(1):59-77. doi: 10.1007/s41745-016-0013-1. Epub 2017 Mar 22.


Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.

Karuppasamy M, Kusmider B, Oliveira TM, Gaubitz C, Prouteau M, Loewith R, Schaffitzel C.

Nat Commun. 2017 Nov 23;8(1):1729. doi: 10.1038/s41467-017-01862-0.


The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists.

Bodur C, Kazyken D, Huang K, Ekim Ustunel B, Siroky KA, Tooley AS, Gonzalez IE, Foley DH, Acosta-Jaquez HA, Barnes TM, Steinl GK, Cho KW, Lumeng CN, Riddle SM, Myers MG Jr, Fingar DC.

EMBO J. 2018 Jan 4;37(1):19-38. doi: 10.15252/embj.201696164. Epub 2017 Nov 17.


Evolutionary Conservation of the Components in the TOR Signaling Pathways.

Tatebe H, Shiozaki K.

Biomolecules. 2017 Nov 1;7(4). pii: E77. doi: 10.3390/biom7040077. Review.


mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.

Wu CC, Hou S, Orr BA, Kuo BR, Youn YH, Ong T, Roth F, Eberhart CG, Robinson GW, Solecki DJ, Taketo MM, Gilbertson RJ, Roussel MF, Han YG.

Dev Cell. 2017 Dec 18;43(6):673-688.e5. doi: 10.1016/j.devcel.2017.10.011. Epub 2017 Nov 2.


Combination of mTOR and MAPK Inhibitors-A Potential Way to Treat Renal Cell Carcinoma.

Chauhan A, Semwal DK, Mishra SP, Goyal S, Marathe R, Semwal RB.

Med Sci (Basel). 2016 Oct 17;4(4). pii: E16. doi: 10.3390/medsci4040016. Review.


Profile of Michael N. Hall, 2017 Albert Lasker Basic Medical Research Awardee: Target of rapamycin, cell growth, and translational control.

Sonenberg N.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11564-11567. doi: 10.1073/pnas.1716203114. Epub 2017 Oct 19. No abstract available.


Twenty-five years of mTOR: Uncovering the link from nutrients to growth.

Sabatini DM.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11818-11825. doi: 10.1073/pnas.1716173114. Epub 2017 Oct 25.


Dynamics of Autophagosome Formation.

Soto-Burgos J, Zhuang X, Jiang L, Bassham DC.

Plant Physiol. 2018 Jan;176(1):219-229. doi: 10.1104/pp.17.01236. Epub 2017 Oct 23. No abstract available.


TOR-mediated regulation of metabolism in aging.

Antikainen H, Driscoll M, Haspel G, Dobrowolski R.

Aging Cell. 2017 Dec;16(6):1219-1233. doi: 10.1111/acel.12689. Epub 2017 Oct 2. Review.


Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus.

Briggs JW, Ren L, Chakrabarti KR, Tsai YC, Weissman AM, Hansen RJ, Gustafson DL, Khan YA, Dinman JD, Khanna C.

PLoS One. 2017 Sep 19;12(9):e0185089. doi: 10.1371/journal.pone.0185089. eCollection 2017.


Prolonged fasting elicits increased hepatic triglyceride accumulation in rats born to dexamethasone-treated mothers.

Pantaleão LC, Murata G, Teixeira CJ, Payolla TB, Santos-Silva JC, Duque-Guimaraes DE, Sodré FS, Lellis-Santos C, Vieira JC, de Souza DN, Gomes PR, Rodrigues SC, Anhe GF, Bordin S.

Sci Rep. 2017 Sep 4;7(1):10367. doi: 10.1038/s41598-017-10642-1.


DNA methylation as a marker of response in rheumatoid arthritis.

Nair N, Wilson AG, Barton A.

Pharmacogenomics. 2017 Sep;18(14):1323-1332. doi: 10.2217/pgs-2016-0195. Epub 2017 Aug 24.


The Architecture of the Rag GTPase Signaling Network.

Nicastro R, Sardu A, Panchaud N, De Virgilio C.

Biomolecules. 2017 Jun 30;7(3). pii: E48. doi: 10.3390/biom7030048. Review.


SnRK1 activates autophagy via the TOR signaling pathway in Arabidopsis thaliana.

Soto-Burgos J, Bassham DC.

PLoS One. 2017 Aug 4;12(8):e0182591. doi: 10.1371/journal.pone.0182591. eCollection 2017.

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