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Glial contributions to neurodegeneration in tauopathies.

Leyns CEG, Holtzman DM.

Mol Neurodegener. 2017 Jun 29;12(1):50. doi: 10.1186/s13024-017-0192-x. Review.


A digital enzyme-linked immunosorbent assay for ultrasensitive measurement of amyloid-β 1-42 peptide in human plasma with utility for studies of Alzheimer's disease therapeutics.

Song L, Lachno DR, Hanlon D, Shepro A, Jeromin A, Gemani D, Talbot JA, Racke MM, Dage JL, Dean RA.

Alzheimers Res Ther. 2016 Dec 15;8(1):58.


Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure.

Xu F, Fu Z, Dass S, Kotarba AE, Davis J, Smith SO, Van Nostrand WE.

Nat Commun. 2016 Nov 21;7:13527. doi: 10.1038/ncomms13527.


Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer's Disease.

Sundaram GS, Dhavale DD, Prior JL, Yan P, Cirrito J, Rath NP, Laforest R, Cairns NJ, Lee JM, Kotzbauer PT, Sharma V.

Sci Rep. 2016 Nov 2;6:35636. doi: 10.1038/srep35636.


Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila.

Fernandez-Funez P, Sanchez-Garcia J, de Mena L, Zhang Y, Levites Y, Khare S, Golde TE, Rincon-Limas DE.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5212-21. doi: 10.1073/pnas.1608045113. Epub 2016 Aug 16.


Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro.

Ozawa D, Nomura R, Mangione PP, Hasegawa K, Okoshi T, Porcari R, Bellotti V, Naiki H.

Sci Rep. 2016 Jul 6;6:29077. doi: 10.1038/srep29077.


Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes.

Kang SS, Kurti A, Wojtas A, Baker KE, Liu CC, Kanekiyo T, Deming Y, Cruchaga C, Estus S, Bu G, Fryer JD.

Hum Mol Genet. 2016 Aug 15;25(16):3467-3475. doi: 10.1093/hmg/ddw188. Epub 2016 Jul 4.


Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer's disease cohorts.

Tan L, Wang HF, Tan MS, Tan CC, Zhu XC, Miao D, Yu WJ, Jiang T, Tan L, Yu JT; Alzheimer’s Disease Neuroimaging Initiative.

Sci Rep. 2016 May 27;6:26027. doi: 10.1038/srep26027.


TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.

Wang Y, Ulland TK, Ulrich JD, Song W, Tzaferis JA, Hole JT, Yuan P, Mahan TE, Shi Y, Gilfillan S, Cella M, Grutzendler J, DeMattos RB, Cirrito JR, Holtzman DM, Colonna M.

J Exp Med. 2016 May 2;213(5):667-75. doi: 10.1084/jem.20151948. Epub 2016 Apr 18.


Novel susceptibility loci for Alzheimer's disease.

Reitz C.

Future Neurol. 2015 Dec;10(6):547-558.


Alternative Splicing in Alzheimer's Disease.

Love JE, Hayden EJ, Rohn TT.

J Parkinsons Dis Alzheimers Dis. 2015 Aug;2(2). pii: 6. Epub 2015 Aug 15.


Microglial malfunction: the third rail in the development of Alzheimer's disease.

Mhatre SD, Tsai CA, Rubin AJ, James ML, Andreasson KI.

Trends Neurosci. 2015 Oct;38(10):621-36. doi: 10.1016/j.tins.2015.08.006. Review.


N-terminal region of myelin basic protein reduces fibrillar amyloid-β deposition in Tg-5xFAD mice.

Ou-Yang MH, Xu F, Liao MC, Davis J, Robinson JK, Van Nostrand WE.

Neurobiol Aging. 2015 Feb;36(2):801-11. doi: 10.1016/j.neurobiolaging.2014.10.006. Epub 2014 Oct 13.


Inhibition of intracellular clusterin attenuates cell death in nephropathic cystinosis.

Sansanwal P, Li L, Sarwal MM.

J Am Soc Nephrol. 2015 Mar;26(3):612-25. doi: 10.1681/ASN.2013060577. Epub 2014 Jul 28.


Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease.

Zhou Y, Hayashi I, Wong J, Tugusheva K, Renger JJ, Zerbinatti C.

PLoS One. 2014 Jul 22;9(7):e103187. doi: 10.1371/journal.pone.0103187. eCollection 2014.


Characterization of a brain permeant fluorescent molecule and visualization of Aβ parenchymal plaques, using real-time multiphoton imaging in transgenic mice.

Sundaram GS, Garai K, Rath NP, Yan P, Cirrito JR, Cairns NJ, Lee JM, Sharma V.

Org Lett. 2014 Jul 18;16(14):3640-3. doi: 10.1021/ol501264q. Epub 2014 Jul 8.


Alzheimer's disease risk genes and mechanisms of disease pathogenesis.

Karch CM, Goate AM.

Biol Psychiatry. 2015 Jan 1;77(1):43-51. doi: 10.1016/j.biopsych.2014.05.006. Epub 2014 May 17. Review.


Early-onset formation of parenchymal plaque amyloid abrogates cerebral microvascular amyloid accumulation in transgenic mice.

Xu F, Kotarba AE, Ou-Yang MH, Fu Z, Davis J, Smith SO, Van Nostrand WE.

J Biol Chem. 2014 Jun 20;289(25):17895-908. doi: 10.1074/jbc.M113.536565. Epub 2014 May 14.


Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature.

Lathe R, Sapronova A, Kotelevtsev Y.

BMC Geriatr. 2014 Mar 21;14:36. doi: 10.1186/1471-2318-14-36. Review.


The role of clusterin in amyloid-β-associated neurodegeneration.

Desikan RS, Thompson WK, Holland D, Hess CP, Brewer JB, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM; Alzheimer’s Disease Neuroimaging Initiative Group.

JAMA Neurol. 2014 Feb;71(2):180-7. doi: 10.1001/jamaneurol.2013.4560.

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