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Items: 1 to 20 of 89

1.

Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D).

Gurney ME, Cogram P, Deacon RM, Rex C, Tranfaglia M.

Sci Rep. 2017 Nov 7;7(1):14653. doi: 10.1038/s41598-017-15028-x.

2.

Sweetness induces sleep through gustatory signalling independent of nutritional value in a starved fruit fly.

Hasegawa T, Tomita J, Hashimoto R, Ueno T, Kume S, Kume K.

Sci Rep. 2017 Oct 30;7(1):14355. doi: 10.1038/s41598-017-14608-1.

3.

The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons.

Bienkowski RS, Banerjee A, Rounds JC, Rha J, Omotade OF, Gross C, Morris KJ, Leung SW, Pak C, Jones SK, Santoro MR, Warren ST, Zheng JQ, Bassell GJ, Corbett AH, Moberg KH.

Cell Rep. 2017 Aug 8;20(6):1372-1384. doi: 10.1016/j.celrep.2017.07.038.

4.

Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome.

Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A.

Sci Signal. 2017 May 2;10(477). pii: eaai8133. doi: 10.1126/scisignal.aai8133.

5.

Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases.

Koon AC, Chan HY.

Front Cell Neurosci. 2017 Mar 21;11:70. doi: 10.3389/fncel.2017.00070. eCollection 2017. Review.

6.

Reduced Lateral Inhibition Impairs Olfactory Computations and Behaviors in a Drosophila Model of Fragile X Syndrome.

Franco LM, Okray Z, Linneweber GA, Hassan BA, Yaksi E.

Curr Biol. 2017 Apr 24;27(8):1111-1123. doi: 10.1016/j.cub.2017.02.065. Epub 2017 Mar 30.

7.

Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.

Mansilla A, Chaves-Sanjuan A, Campillo NE, Semelidou O, Martínez-González L, Infantes L, González-Rubio JM, Gil C, Conde S, Skoulakis EM, Ferrús A, Martínez A, Sánchez-Barrena MJ.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E999-E1008. doi: 10.1073/pnas.1611089114. Epub 2017 Jan 24.

8.

A New Link Between Insulin Signaling and Fragile X Syndrome.

Bu B, Zhang L.

Neurosci Bull. 2017 Feb;33(1):118-120. doi: 10.1007/s12264-016-0083-0. Epub 2016 Nov 12. No abstract available.

PMID:
27838827
9.

Splice form-dependent regulation of axonal arbor complexity by FMRP.

Zimmer SE, Doll SG, Garcia ADR, Akins MR.

Dev Neurobiol. 2017 Jun;77(6):738-752. doi: 10.1002/dneu.22453. Epub 2016 Oct 3.

PMID:
27643955
10.

Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models.

Choi CH, Schoenfeld BP, Bell AJ, Hinchey J, Rosenfelt C, Gertner MJ, Campbell SR, Emerson D, Hinchey P, Kollaros M, Ferrick NJ, Chambers DB, Langer S, Sust S, Malik A, Terlizzi AM, Liebelt DA, Ferreiro D, Sharma A, Koenigsberg E, Choi RJ, Louneva N, Arnold SE, Featherstone RE, Siegel SJ, Zukin RS, McDonald TV, Bolduc FV, Jongens TA, McBride SM.

Front Behav Neurosci. 2016 Jun 30;10:136. doi: 10.3389/fnbeh.2016.00136. eCollection 2016.

11.

Progress toward therapeutic potential for AFQ056 in Fragile X syndrome.

Sourial M, Cheng C, Doering LC.

J Exp Pharmacol. 2013 Jul 16;5:45-54. doi: 10.2147/JEP.S27044. eCollection 2013. Review.

12.

Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model.

Monyak RE, Emerson D, Schoenfeld BP, Zheng X, Chambers DB, Rosenfelt C, Langer S, Hinchey P, Choi CH, McDonald TV, Bolduc FV, Sehgal A, McBride SMJ, Jongens TA.

Mol Psychiatry. 2017 Aug;22(8):1140-1148. doi: 10.1038/mp.2016.51. Epub 2016 Apr 19.

13.

New X-chromosomal interactors of dFMRP regulate axonal and synaptic morphology of brain neurons in Drosophila melanogaster.

Georgieva D, Dimitrov R, Kitanova M, Genova G.

Biotechnol Biotechnol Equip. 2014 Jul 4;28(4):697-709. Epub 2014 Oct 23.

14.

Drosophila as an In Vivo Model for Human Neurodegenerative Disease.

McGurk L, Berson A, Bonini NM.

Genetics. 2015 Oct;201(2):377-402. doi: 10.1534/genetics.115.179457. Review.

15.

Neurodegeneration and microtubule dynamics: death by a thousand cuts.

Dubey J, Ratnakaran N, Koushika SP.

Front Cell Neurosci. 2015 Sep 9;9:343. doi: 10.3389/fncel.2015.00343. eCollection 2015. Review. Erratum in: Front Cell Neurosci. 2016;10:26.

16.

Synergistic interactions between Drosophila orthologues of genes spanned by de novo human CNVs support multiple-hit models of autism.

Grice SJ, Liu JL, Webber C.

PLoS Genet. 2015 Mar 27;11(3):e1004998. doi: 10.1371/journal.pgen.1004998. eCollection 2015 Mar.

17.

Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins.

Chen E, Joseph S.

Biochimie. 2015 Jul;114:147-54. doi: 10.1016/j.biochi.2015.02.005. Epub 2015 Feb 17. Review.

18.

A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function.

Okray Z, de Esch CE, Van Esch H, Devriendt K, Claeys A, Yan J, Verbeeck J, Froyen G, Willemsen R, de Vrij FM, Hassan BA.

EMBO Mol Med. 2015 Apr;7(4):423-37. doi: 10.15252/emmm.201404576.

19.

Epigenetic regulation of neuronal dendrite and dendritic spine development.

Smrt RD, Zhao X.

Front Biol (Beijing). 2010 Aug;5(4):304-323.

20.

PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.

Choi CH, Schoenfeld BP, Weisz ED, Bell AJ, Chambers DB, Hinchey J, Choi RJ, Hinchey P, Kollaros M, Gertner MJ, Ferrick NJ, Terlizzi AM, Yohn N, Koenigsberg E, Liebelt DA, Zukin RS, Woo NH, Tranfaglia MR, Louneva N, Arnold SE, Siegel SJ, Bolduc FV, McDonald TV, Jongens TA, McBride SM.

J Neurosci. 2015 Jan 7;35(1):396-408. doi: 10.1523/JNEUROSCI.1356-12.2015.

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