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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S.

Nat Commun. 2017 Feb 17;8:14432. doi: 10.1038/ncomms14432.


Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation.

Onaka AT, Toyofuku N, Inoue T, Okita AK, Sagawa M, Su J, Shitanda T, Matsuyama R, Zafar F, Takahashi TS, Masukata H, Nakagawa T.

Nucleic Acids Res. 2016 Dec 15;44(22):10744-10757. Epub 2016 Oct 3.


Dbl2 Regulates Rad51 and DNA Joint Molecule Metabolism to Ensure Proper Meiotic Chromosome Segregation.

Polakova S, Molnarova L, Hyppa RW, Benko Z, Misova I, Schleiffer A, Smith GR, Gregan J.

PLoS Genet. 2016 Jun 15;12(6):e1006102. doi: 10.1371/journal.pgen.1006102. eCollection 2016 Jun.


Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes.

Carter R, Westhorpe A, Romero MJ, Habtemariam A, Gallevo CR, Bark Y, Menezes N, Sadler PJ, Sharma RA.

Sci Rep. 2016 Feb 12;6:20596. doi: 10.1038/srep20596.


Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response.

Xing M, Wang X, Palmai-Pallag T, Shen H, Helleday T, Hickson ID, Ying S.

Oncotarget. 2015 Nov 10;6(35):37638-46. doi: 10.18632/oncotarget.5497.


Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.

Rossi SE, Ajazi A, Carotenuto W, Foiani M, Giannattasio M.

Cell Rep. 2015 Oct 6;13(1):80-92. doi: 10.1016/j.celrep.2015.08.073. Epub 2015 Sep 24.


Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1.

Blanco MG, Matos J.

Front Genet. 2015 Jul 30;6:253. doi: 10.3389/fgene.2015.00253. eCollection 2015. Review.


Ku stabilizes replication forks in the absence of Brc1.

Sánchez A, Russell P.

PLoS One. 2015 May 12;10(5):e0126598. doi: 10.1371/journal.pone.0126598. eCollection 2015.


Srs2 promotes Mus81-Mms4-mediated resolution of recombination intermediates.

Chavdarova M, Marini V, Sisakova A, Sedlackova H, Vigasova D, Brill SJ, Lisby M, Krejci L.

Nucleic Acids Res. 2015 Apr 20;43(7):3626-42. doi: 10.1093/nar/gkv198. Epub 2015 Mar 12.


A physiological significance of the functional interaction between Mus81 and Rad27 in homologous recombination repair.

Thu HP, Nguyen TA, Munashingha PR, Kwon B, Dao Van Q, Seo YS.

Nucleic Acids Res. 2015 Feb 18;43(3):1684-99. doi: 10.1093/nar/gkv025. Epub 2015 Jan 27.


Restriction of replication fork regression activities by a conserved SMC complex.

Xue X, Choi K, Bonner J, Chiba T, Kwon Y, Xu Y, Sanchez H, Wyman C, Niu H, Zhao X, Sung P.

Mol Cell. 2014 Nov 6;56(3):436-45. doi: 10.1016/j.molcel.2014.09.013. Epub 2014 Oct 16.


Increased meiotic crossovers and reduced genome stability in absence of Schizosaccharomyces pombe Rad16 (XPF).

Mastro TL, Forsburg SL.

Genetics. 2014 Dec;198(4):1457-72. doi: 10.1534/genetics.114.171355. Epub 2014 Oct 6.


Holliday junction resolvases.

Wyatt HD, West SC.

Cold Spring Harb Perspect Biol. 2014 Sep 2;6(9):a023192. doi: 10.1101/cshperspect.a023192. Review.


The dissolution of double Holliday junctions.

Bizard AH, Hickson ID.

Cold Spring Harb Perspect Biol. 2014 Jul 1;6(7):a016477. doi: 10.1101/cshperspect.a016477. Review.


Essential domains of Schizosaccharomyces pombe Rad8 required for DNA damage response.

Ding L, Forsburg SL.

G3 (Bethesda). 2014 May 28;4(8):1373-84. doi: 10.1534/g3.114.011346.


DNA damage repair machinery and HIV escape from innate immune sensing.

Brégnard C, Benkirane M, Laguette N.

Front Microbiol. 2014 Apr 22;5:176. doi: 10.3389/fmicb.2014.00176. eCollection 2014. Review.


Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates.

Gwon GH, Jo A, Baek K, Jin KS, Fu Y, Lee JB, Kim Y, Cho Y.

EMBO J. 2014 May 2;33(9):1061-72. doi: 10.1002/embj.201487820. Epub 2014 Apr 14.


Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex.

Amangyeld T, Shin YK, Lee M, Kwon B, Seo YS.

Nucleic Acids Res. 2014 May;42(9):5846-62. doi: 10.1093/nar/gku237. Epub 2014 Apr 1.


Substrate specificity of the MUS81-EME2 structure selective endonuclease.

Pepe A, West SC.

Nucleic Acids Res. 2014 Apr;42(6):3833-45. doi: 10.1093/nar/gkt1333. Epub 2013 Dec 25.


Survival of the replication checkpoint deficient cells requires MUS81-RAD52 function.

Murfuni I, Basile G, Subramanyam S, Malacaria E, Bignami M, Spies M, Franchitto A, Pichierri P.

PLoS Genet. 2013 Oct;9(10):e1003910. doi: 10.1371/journal.pgen.1003910. Epub 2013 Oct 31.

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