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Items: 16


Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment.

Rudenko A, Seo J, Hu J, Su SC, de Anda FC, Durak O, Ericsson M, Carlén M, Tsai LH.

J Neurosci. 2015 Feb 11;35(6):2372-83. doi: 10.1523/JNEUROSCI.0969-14.2015.


X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.

Hu H, Haas SA, Chelly J, Van Esch H, Raynaud M, de Brouwer AP, Weinert S, Froyen G, Frints SG, Laumonnier F, Zemojtel T, Love MI, Richard H, Emde AK, Bienek M, Jensen C, Hambrock M, Fischer U, Langnick C, Feldkamp M, Wissink-Lindhout W, Lebrun N, Castelnau L, Rucci J, Montjean R, Dorseuil O, Billuart P, Stuhlmann T, Shaw M, Corbett MA, Gardner A, Willis-Owen S, Tan C, Friend KL, Belet S, van Roozendaal KE, Jimenez-Pocquet M, Moizard MP, Ronce N, Sun R, O'Keeffe S, Chenna R, van Bömmel A, Göke J, Hackett A, Field M, Christie L, Boyle J, Haan E, Nelson J, Turner G, Baynam G, Gillessen-Kaesbach G, Müller U, Steinberger D, Budny B, Badura-Stronka M, Latos-Bieleńska A, Ousager LB, Wieacker P, Rodríguez Criado G, Bondeson ML, Annerén G, Dufke A, Cohen M, Van Maldergem L, Vincent-Delorme C, Echenne B, Simon-Bouy B, Kleefstra T, Willemsen M, Fryns JP, Devriendt K, Ullmann R, Vingron M, Wrogemann K, Wienker TF, Tzschach A, van Bokhoven H, Gecz J, Jentsch TJ, Chen W, Ropers HH, Kalscheuer VM.

Mol Psychiatry. 2016 Jan;21(1):133-48. doi: 10.1038/mp.2014.193. Epub 2015 Feb 3.


PCTAIRE1 regulates p27 stability, apoptosis and tumor growth in malignant melanoma.

Yanagi T, Reed JC, Matsuzawa S.

Oncoscience. 2014 Oct 5;1(10):624-33. eCollection 2014.


RNA interference screening identifies a novel role for PCTK1/CDK16 in medulloblastoma with c-Myc amplification.

Ćwiek P, Leni Z, Salm F, Dimitrova V, Styp-Rekowska B, Chiriano G, Carroll M, Höland K, Djonov V, Scapozza L, Guiry P, Arcaro A.

Oncotarget. 2015 Jan 1;6(1):116-29.


At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology.

McLinden KA, Trunova S, Giniger E.

Brain Disord Ther. 2012 Jul;2012(Suppl 1):001.


p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1).

Zhao XS, Fu WY, Chien WW, Li Z, Fu AK, Ip NY.

PLoS One. 2014 Oct 16;9(10):e110584. doi: 10.1371/journal.pone.0110584. eCollection 2014.


PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells.

Yanagi T, Krajewska M, Matsuzawa S, Reed JC.

Cancer Res. 2014 Oct 15;74(20):5795-807. doi: 10.1158/0008-5472.CAN-14-0872. Epub 2014 Sep 9.


Orphan kinases turn eccentric: a new class of cyclin Y-activated, membrane-targeted CDKs.

Mikolcevic P, Rainer J, Geley S.

Cell Cycle. 2012 Oct 15;11(20):3758-68. doi: 10.4161/cc.21592. Epub 2012 Aug 16. Review.


Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.

Shehata SN, Hunter RW, Ohta E, Peggie MW, Lou HJ, Sicheri F, Zeqiraj E, Turk BE, Sakamoto K.

Cell Signal. 2012 Nov;24(11):2085-94. doi: 10.1016/j.cellsig.2012.06.018. Epub 2012 Jul 11.


Signaling in migrating neurons: from molecules to networks.

Khodosevich K, Monyer H.

Front Neurosci. 2011 Mar 28;5:28. doi: 10.3389/fnins.2011.00028. eCollection 2011.


CDK5 serves as a major control point in neurotransmitter release.

Kim SH, Ryan TA.

Neuron. 2010 Sep 9;67(5):797-809. doi: 10.1016/j.neuron.2010.08.003.


Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity.

Poore CP, Sundaram JR, Pareek TK, Fu A, Amin N, Mohamed NE, Zheng YL, Goh AX, Lai MK, Ip NY, Pant HC, Kesavapany S.

J Neurosci. 2010 Jun 23;30(25):8457-67. doi: 10.1523/JNEUROSCI.6062-09.2010.


Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development.

Mokalled MH, Johnson A, Kim Y, Oh J, Olson EN.

Development. 2010 Jul;137(14):2365-74. doi: 10.1242/dev.047605. Epub 2010 Jun 9.


Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components.

Ou CY, Poon VY, Maeder CI, Watanabe S, Lehrman EK, Fu AK, Park M, Fu WY, Jorgensen EM, Ip NY, Shen K.

Cell. 2010 May 28;141(5):846-58. doi: 10.1016/j.cell.2010.04.011.


Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons.

Cheung ZH, Chin WH, Chen Y, Ng YP, Ip NY.

PLoS Biol. 2007 Apr;5(4):e63.


Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity.

Fu AK, Fu WY, Ng AK, Chien WW, Ng YP, Wang JH, Ip NY.

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6728-33. Epub 2004 Apr 19.

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