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Items: 1 to 20 of 35

1.

Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1.

Fujita K, Mao Y, Uchida S, Chen X, Shiwaku H, Tamura T, Ito H, Watase K, Homma H, Tagawa K, Sudol M, Okazawa H.

Nat Commun. 2017 Nov 30;8(1):1864. doi: 10.1038/s41467-017-01790-z.

2.

Ultra-Early Phase pathologies of Alzheimer's disease and other neurodegenerative diseases.

Okazawa H.

Proc Jpn Acad Ser B Phys Biol Sci. 2017;93(6):361-377. doi: 10.2183/pjab.93.022. Review.

3.

Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries.

Imamura T, Fujita K, Tagawa K, Ikura T, Chen X, Homma H, Tamura T, Mao Y, Taniguchi JB, Motoki K, Nakabayashi M, Ito N, Yamada K, Tomii K, Okano H, Kaye J, Finkbeiner S, Okazawa H.

Sci Rep. 2016 Sep 22;6:33861. doi: 10.1038/srep33861.

4.

The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing.

Mao Y, Tamura T, Yuki Y, Abe D, Tamada Y, Imoto S, Tanaka H, Homma H, Tagawa K, Miyano S, Okazawa H.

Cell Death Dis. 2016 Apr 28;7:e2207. doi: 10.1038/cddis.2016.101.

5.

HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice.

Ito H, Fujita K, Tagawa K, Chen X, Homma H, Sasabe T, Shimizu J, Shimizu S, Tamura T, Muramatsu S, Okazawa H.

EMBO Mol Med. 2015 Jan;7(1):78-101. doi: 10.15252/emmm.201404392.

6.

The splicing factor PQBP1 regulates mesodermal and neural development through FGF signaling.

Iwasaki Y, Thomsen GH.

Development. 2014 Oct;141(19):3740-51. doi: 10.1242/dev.106658. Epub 2014 Sep 10.

7.

The expanding role for chromatin and transcription in polyglutamine disease.

Mohan RD, Abmayr SM, Workman JL.

Curr Opin Genet Dev. 2014 Jun;26:96-104. doi: 10.1016/j.gde.2014.06.008. Epub 2014 Aug 11. Review.

8.

In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.

Ito H, Shiwaku H, Yoshida C, Homma H, Luo H, Chen X, Fujita K, Musante L, Fischer U, Frints SG, Romano C, Ikeuchi Y, Shimamura T, Imoto S, Miyano S, Muramatsu SI, Kawauchi T, Hoshino M, Sudol M, Arumughan A, Wanker EE, Rich T, Schwartz C, Matsuzaki F, Bonni A, Kalscheuer VM, Okazawa H.

Mol Psychiatry. 2015 Apr;20(4):459-71. doi: 10.1038/mp.2014.69. Epub 2014 Jul 29.

9.

Mapping the self-association domains of ataxin-1: identification of novel non overlapping motifs.

Menon RP, Soong D, de Chiara C, Holt M, McCormick JE, Anilkumar N, Pastore A.

PeerJ. 2014 Mar 25;2:e323. doi: 10.7717/peerj.323. eCollection 2014.

10.

Kaleidoscopic protein-protein interactions in the life and death of ataxin-1: new strategies against protein aggregation.

de Chiara C, Pastore A.

Trends Neurosci. 2014 Apr;37(4):211-8. doi: 10.1016/j.tins.2014.02.003. Epub 2014 Mar 11. Review.

11.

Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.

Matilla-Dueñas A, Ashizawa T, Brice A, Magri S, McFarland KN, Pandolfo M, Pulst SM, Riess O, Rubinsztein DC, Schmidt J, Schmidt T, Scoles DR, Stevanin G, Taroni F, Underwood BR, Sánchez I.

Cerebellum. 2014 Apr;13(2):269-302. doi: 10.1007/s12311-013-0539-y.

12.

The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons.

Ikeuchi Y, de la Torre-Ubieta L, Matsuda T, Steen H, Okazawa H, Bonni A.

Cell Rep. 2013 Sep 12;4(5):879-89. doi: 10.1016/j.celrep.2013.07.042. Epub 2013 Aug 29.

13.

Sox2 transcriptionally regulates PQBP1, an intellectual disability-microcephaly causative gene, in neural stem progenitor cells.

Li C, Ito H, Fujita K, Shiwaku H, Qi Y, Tagawa K, Tamura T, Okazawa H.

PLoS One. 2013 Jul 16;8(7):e68627. doi: 10.1371/journal.pone.0068627. Print 2013.

14.

PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth.

Wang Q, Moore MJ, Adelmant G, Marto JA, Silver PA.

Genes Dev. 2013 Mar 15;27(6):615-26. doi: 10.1101/gad.212308.112.

15.

The importance of serine 776 in Ataxin-1 partner selection: a FRET analysis.

Menon RP, Soong D, de Chiara C, Holt MR, Anilkumar N, Pastore A.

Sci Rep. 2012;2:919. doi: 10.1038/srep00919. Epub 2012 Dec 4.

16.

Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.

Switonski PM, Szlachcic WJ, Gabka A, Krzyzosiak WJ, Figiel M.

Mol Neurobiol. 2012 Oct;46(2):430-66. doi: 10.1007/s12035-012-8316-3. Epub 2012 Sep 4. Review.

17.

Molecular insights into the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1.

Sudol M, McDonald CB, Farooq A.

FEBS Lett. 2012 Aug 14;586(17):2795-9. doi: 10.1016/j.febslet.2012.03.041. Epub 2012 Mar 28. Review.

18.

Solution model of the intrinsically disordered polyglutamine tract-binding protein-1.

Rees M, Gorba C, de Chiara C, Bui TT, Garcia-Maya M, Drake AF, Okazawa H, Pastore A, Svergun D, Chen YW.

Biophys J. 2012 Apr 4;102(7):1608-16. doi: 10.1016/j.bpj.2012.02.047. Epub 2012 Apr 3.

19.

Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease.

Tamura T, Sone M, Iwatsubo T, Tagawa K, Wanker EE, Okazawa H.

PLoS One. 2011;6(11):e27408. doi: 10.1371/journal.pone.0027408. Epub 2011 Nov 7. Erratum in: PLoS One. 2012;7(1). doi: 10.1371/annotation/e436994f-3b22-4b35-bd29-49992f64a584.

20.

14-3-3 Binding to ataxin-1(ATXN1) regulates its dephosphorylation at Ser-776 and transport to the nucleus.

Lai S, O'Callaghan B, Zoghbi HY, Orr HT.

J Biol Chem. 2011 Oct 7;286(40):34606-16. doi: 10.1074/jbc.M111.238527. Epub 2011 Aug 11. Erratum in: J Biol Chem. 2013 Mar 1;288(9):6590.

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