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Items: 1 to 20 of 415


Threading the biophysics of mammalian Slo1 channels onto structures of an invertebrate Slo1 channel.

Zhou Y, Yang H, Cui J, Lingle CJ.

J Gen Physiol. 2017 Nov 6;149(11):985-1007. doi: 10.1085/jgp.201711845. Epub 2017 Oct 12. Review.


Protein kinase A-induced internalization of Slack channels from the neuronal membrane occurs by adaptor protein-2/clathrin-mediated endocytosis.

Gururaj S, Evely KM, Pryce KD, Li J, Qu J, Bhattacharjee A.

J Biol Chem. 2017 Nov 24;292(47):19304-19314. doi: 10.1074/jbc.M117.804716. Epub 2017 Oct 5.


Helical jackknives control the gates of the double-pore K+ uptake system KtrAB.

Diskowski M, Mehdipour AR, Wunnicke D, Mills DJ, Mikusevic V, Bärland N, Hoffmann J, Morgner N, Steinhoff HJ, Hummer G, Vonck J, Hänelt I.

Elife. 2017 May 16;6. pii: e24303. doi: 10.7554/eLife.24303.


A genetic variant of the sperm-specific SLO3 K+ channel has altered pH and Ca2+ sensitivities.

Geng Y, Ferreira JJ, Dzikunu V, Butler A, Lybaert P, Yuan P, Magleby KL, Salkoff L, Santi CM.

J Biol Chem. 2017 May 26;292(21):8978-8987. doi: 10.1074/jbc.M117.776013. Epub 2017 Apr 4.


hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed state.

Malak OA, Es-Salah-Lamoureux Z, Loussouarn G.

Sci Rep. 2017 Mar 2;7(1):113. doi: 10.1038/s41598-017-00155-2.


A slick, slack pathway through the pore.

Rothberg BS.

J Physiol. 2017 Apr 1;595(7):2337-2338. doi: 10.1113/JP273497. Epub 2017 Mar 5. No abstract available.


Understanding the conformational motions of RCK gating rings.

Giraldez T, Rothberg BS.

J Gen Physiol. 2017 Apr 3;149(4):431-441. doi: 10.1085/jgp.201611726. Epub 2017 Feb 28. Review.


Structural Study of Heterogeneous Biological Samples by Cryoelectron Microscopy and Image Processing.

White HE, Ignatiou A, Clare DK, Orlova EV.

Biomed Res Int. 2017;2017:1032432. doi: 10.1155/2017/1032432. Epub 2017 Jan 15. Review.


Understanding the FRET Signatures of Interacting Membrane Proteins.

King C, Raicu V, Hristova K.

J Biol Chem. 2017 Mar 31;292(13):5291-5310. doi: 10.1074/jbc.M116.764282. Epub 2017 Feb 9.


Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore.

Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V.

Mol Pharmacol. 2017 Apr;91(4):392-402. doi: 10.1124/mol.116.108068. Epub 2017 Jan 26.


Single-Walled Carbon Nanotubes: Mimics of Biological Ion Channels.

Amiri H, Shepard KL, Nuckolls C, Hernández Sánchez R.

Nano Lett. 2017 Feb 8;17(2):1204-1211. doi: 10.1021/acs.nanolett.6b04967. Epub 2017 Jan 19.


Signatures of Mechanosensitive Gating.

Morris RG.

Biophys J. 2017 Jan 10;112(1):3-9. doi: 10.1016/j.bpj.2016.12.009.


A reduced mechanical model for cAMP-modulated gating in HCN channels.

Weißgraeber S, Saponaro A, Thiel G, Hamacher K.

Sci Rep. 2017 Jan 11;7:40168. doi: 10.1038/srep40168.


Single Channel Recordings Reveal Differential β2 Subunit Modulations Between Mammalian and Drosophila BKCa(β2) Channels.

Yan Z, Hu B, Huang Z, Zhong L, Guo X, Weng A, Xiao F, Zeng W, Zhang Y, Ding J, Hou P.

PLoS One. 2016 Oct 18;11(10):e0163308. doi: 10.1371/journal.pone.0163308. eCollection 2016.


Pore size matters for potassium channel conductance.

Naranjo D, Moldenhauer H, Pincuntureo M, Díaz-Franulic I.

J Gen Physiol. 2016 Oct;148(4):277-91. doi: 10.1085/jgp.201611625. Epub 2016 Sep 12. Review.


Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids.

Lee SJ, Ren F, Zangerl-Plessl EM, Heyman S, Stary-Weinzinger A, Yuan P, Nichols CG.

J Gen Physiol. 2016 Sep;148(3):227-37. doi: 10.1085/jgp.201611616. Epub 2016 Aug 15.


Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles.

Kim DM, Dikiy I, Upadhyay V, Posson DJ, Eliezer D, Nimigean CM.

J Gen Physiol. 2016 Aug;148(2):119-32. doi: 10.1085/jgp.201611602. Epub 2016 Jul 18.


Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.

Zhang Y, Colenso CK, El Harchi A, Cheng H, Witchel HJ, Dempsey CE, Hancox JC.

Biochem Pharmacol. 2016 Aug 1;113:24-35. doi: 10.1016/j.bcp.2016.05.013. Epub 2016 May 30.


Challenges in structural approaches to cell modeling.

Im W, Liang J, Olson A, Zhou HX, Vajda S, Vakser IA.

J Mol Biol. 2016 Jul 31;428(15):2943-64. doi: 10.1016/j.jmb.2016.05.024. Epub 2016 May 30. Review.


New potential binding determinant for hERG channel inhibitors.

Saxena P, Zangerl-Plessl EM, Linder T, Windisch A, Hohaus A, Timin E, Hering S, Stary-Weinzinger A.

Sci Rep. 2016 Apr 12;6:24182. doi: 10.1038/srep24182.

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