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Chronic diazepam administration increases the expression of Lcn2 in the CNS.

Furukawa T, Shimoyama S, Miki Y, Nikaido Y, Koga K, Nakamura K, Wakabayashi K, Ueno S.

Pharmacol Res Perspect. 2017 Jan 31;5(1):e00283. doi: 10.1002/prp2.283. eCollection 2017 Feb.


A realist evaluation of patients' decisions to deprescribe in the EMPOWER trial.

Martin P, Tannenbaum C.

BMJ Open. 2017 May 4;7(4):e015959. doi: 10.1136/bmjopen-2017-015959.


Anxiety symptoms and risk of cognitive decline in older community-dwelling men.

Kassem AM, Ganguli M, Yaffe K, Hanlon JT, Lopez OL, Wilson JW, Cauley JA; Osteoporotic Fractures in Men (MrOS) Study Research Group.

Int Psychogeriatr. 2017 Jul;29(7):1137-1145. doi: 10.1017/S104161021700045X. Epub 2017 Apr 9.


No End in Sight: Benzodiazepine Use in Older Adults in the United States.

Maust DT, Kales HC, Wiechers IR, Blow FC, Olfson M.

J Am Geriatr Soc. 2016 Dec;64(12):2546-2553. doi: 10.1111/jgs.14379. Epub 2016 Nov 23.


Patterns of Psychiatric Outpatient Practice in Taiwan: A Nationwide Survey.

Dai YX, Chen MH, Chen TJ, Lin MH.

Int J Environ Res Public Health. 2016 Sep 28;13(10). pii: E955.


Bridging the gap between education and appropriate use of benzodiazepines in psychiatric clinical practice.

Dell'Osso B, Albert U, Atti AR, Carmassi C, Carrà G, Cosci F, Del Vecchio V, Di Nicola M, Ferrari S, Goracci A, Iasevoli F, Luciano M, Martinotti G, Nanni MG, Nivoli A, Pinna F, Poloni N, Pompili M, Sampogna G, Tarricone I, Tosato S, Volpe U, Fiorillo A.

Neuropsychiatr Dis Treat. 2015 Jul 30;11:1885-909. doi: 10.2147/NDT.S83130. eCollection 2015. Review.


Valerenic Acid Protects Against Physical and Psychological Stress by Reducing the Turnover of Serotonin and Norepinephrine in Mouse Hippocampus-Amygdala Region.

Jung HY, Yoo DY, Nam SM, Kim JW, Choi JH, Yoo M, Lee S, Yoon YS, Hwang IK.

J Med Food. 2015 Dec;18(12):1333-9. doi: 10.1089/jmf.2014.3412. Epub 2015 Jul 15.


Impact of alprazolam in allostatic load and neurocognition of patients with anxiety disorders and chronic stress (GEMA): observational study protocol.

Soria CA, Remedi C, Núñez DA, D'Alessio L, Roldán EJ.

BMJ Open. 2015 Jul 14;5(7):e007231. doi: 10.1136/bmjopen-2014-007231. Erratum in: BMJ Open. 2015;5(8):e007231.


Benzodiazepine prescribing in children under 15 years of age receiving free medical care on the General Medical Services scheme in Ireland.

O'Sullivan K, Reulbach U, Boland F, Motterlini N, Kelly D, Bennett K, Fahey T.

BMJ Open. 2015 Jun 9;5(6):e007070. doi: 10.1136/bmjopen-2014-007070.


The anxiolytic effects of valtrate in rats involves changes of corticosterone levels.

Shi SN, Shi JL, Liu Y, Wang YL, Wang CG, Hou WH, Guo JY.

Evid Based Complement Alternat Med. 2014;2014:325948. doi: 10.1155/2014/325948. Epub 2014 Mar 20.


Turning over the rocks: role of anticholinergics and benzodiazepines in cognitive decline and falls.

Farrell B, Eisener-Parsche P, Dalton D.

Can Fam Physician. 2014 Apr;60(4):345-50. No abstract available.


Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: retrospective cohort study.

Weich S, Pearce HL, Croft P, Singh S, Crome I, Bashford J, Frisher M.

BMJ. 2014 Mar 19;348:g1996. doi: 10.1136/bmj.g1996.


Antiglucocorticoid therapy for older adults with anxiety and co-occurring cognitive dysfunction: results from a pilot study with mifepristone.

Lenze EJ, Hershey T, Newcomer JW, Karp JF, Blumberger D, Anger J, Doré P, Dixon D.

Int J Geriatr Psychiatry. 2014 Sep;29(9):962-9. doi: 10.1002/gps.4085. Epub 2014 Mar 14.


On-the-road driving performance and driving-related skills in older untreated insomnia patients and chronic users of hypnotics.

Leufkens TR, Ramaekers JG, de Weerd AW, Riedel WJ, Vermeeren A.

Psychopharmacology (Berl). 2014 Jul;231(14):2851-65. doi: 10.1007/s00213-014-3455-z. Epub 2014 Feb 2.


Management of insomnia and long-term use of sedative-hypnotic drugs in older patients.

McMillan JM, Aitken E, Holroyd-Leduc JM.

CMAJ. 2013 Nov 19;185(17):1499-505. doi: 10.1503/cmaj.130025. Epub 2013 Sep 23. Review. No abstract available.


Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based study.

Amieva H, Meillon C, Helmer C, Barberger-Gateau P, Dartigues JF.

PLoS One. 2013;8(1):e52755. doi: 10.1371/journal.pone.0052755. Epub 2013 Jan 11.


Benzodiazepine use and risk of dementia: prospective population based study.

Billioti de Gage S, Bégaud B, Bazin F, Verdoux H, Dartigues JF, Pérès K, Kurth T, Pariente A.

BMJ. 2012 Sep 27;345:e6231. doi: 10.1136/bmj.e6231.


CNS medications as predictors of precipitous cognitive decline in the cognitively disabled aged: a longitudinal population-based study.

Puustinen J, Nurminen J, Vahlberg T, Lyles A, Isoaho R, Räihä I, Kivelä SL.

Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):57-68. doi: 10.1159/000336710. Epub 2012 Mar 16.


A lifespan view of anxiety disorders.

Lenze EJ, Wetherell JL.

Dialogues Clin Neurosci. 2011;13(4):381-99. Review.

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