Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 25

1.

Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.

Huang W, Zhang Z, Ranade RM, Gillespie JR, Barros-Álvarez X, Creason SA, Shibata S, Verlinde CLMJ, Hol WGJ, Buckner FS, Fan E.

Bioorg Med Chem Lett. 2017 Jun 15;27(12):2702-2707. doi: 10.1016/j.bmcl.2017.04.048. Epub 2017 Apr 17.

PMID:
28465105
2.

Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms.

Moen SO, Edwards TE, Dranow DM, Clifton MC, Sankaran B, Van Voorhis WC, Sharma A, Manoil C, Staker BL, Myler PJ, Lorimer DD.

Sci Rep. 2017 Mar 16;7(1):223. doi: 10.1038/s41598-017-00367-6.

3.

Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.

Huang W, Zhang Z, Barros-Álvarez X, Koh CY, Ranade RM, Gillespie JR, Creason SA, Shibata S, Verlinde CL, Hol WG, Buckner FS, Fan E.

Eur J Med Chem. 2016 Nov 29;124:1081-1092. doi: 10.1016/j.ejmech.2016.10.024. Epub 2016 Oct 14.

PMID:
27788467
4.

5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.

Zhang Z, Koh CY, Ranade RM, Shibata S, Gillespie JR, Hulverson MA, Huang W, Nguyen J, Pendem N, Gelb MH, Verlinde CL, Hol WG, Buckner FS, Fan E.

ACS Infect Dis. 2016 Jun 10;2(6):399-404. doi: 10.1021/acsinfecdis.6b00036. Epub 2016 Apr 11.

5.

Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.

Ojo KK, Ranade RM, Zhang Z, Dranow DM, Myers JB, Choi R, Nakazawa Hewitt S, Edwards TE, Davies DR, Lorimer D, Boyle SM, Barrett LK, Buckner FS, Fan E, Van Voorhis WC.

PLoS One. 2016 Aug 8;11(8):e0160350. doi: 10.1371/journal.pone.0160350. eCollection 2016. Erratum in: PLoS One. 2016;11(9):e0163641.

6.

Synthesis and fungicidal activity of pyrazole derivatives containing 1,2,3,4-tetrahydroquinoline.

Lei P, Zhang X, Xu Y, Xu G, Liu X, Yang X, Zhang X, Ling Y.

Chem Cent J. 2016 Jul 4;10:40. doi: 10.1186/s13065-016-0186-8. eCollection 2016.

7.

Essentiality Assessment of Cysteinyl and Lysyl-tRNA Synthetases of Mycobacterium smegmatis.

Ravishankar S, Ambady A, Swetha RG, Anbarasu A, Ramaiah S, Sambandamurthy VK.

PLoS One. 2016 Jan 21;11(1):e0147188. doi: 10.1371/journal.pone.0147188. eCollection 2016.

8.

Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites.

Ranade RM, Zhang Z, Gillespie JR, Shibata S, Verlinde CL, Hol WG, Fan E, Buckner FS.

Antimicrob Agents Chemother. 2015 Nov;59(11):7128-31. doi: 10.1128/AAC.01573-15. Epub 2015 Aug 31.

9.

Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases.

Hussain T, Yogavel M, Sharma A.

Antimicrob Agents Chemother. 2015 Apr;59(4):1856-67. doi: 10.1128/AAC.02220-13. Epub 2015 Jan 12.

10.

Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.

Pham JS, Dawson KL, Jackson KE, Lim EE, Pasaje CF, Turner KE, Ralph SA.

Int J Parasitol Drugs Drug Resist. 2013 Nov 11;4(1):1-13. doi: 10.1016/j.ijpddr.2013.10.001. eCollection 2014 Apr. Review.

11.

Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis.

Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE 3rd, Sherman DR, Parish T, Sacchettini JC.

PLoS One. 2013 Sep 23;8(9):e75245. doi: 10.1371/journal.pone.0075245. eCollection 2013.

12.
13.

Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection.

Koh CY, Kim JE, Shibata S, Ranade RM, Yu M, Liu J, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG.

Structure. 2012 Oct 10;20(10):1681-91. doi: 10.1016/j.str.2012.07.011. Epub 2012 Aug 16.

14.

Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization.

Shibata S, Gillespie JR, Ranade RM, Koh CY, Kim JE, Laydbak JU, Zucker FH, Hol WG, Verlinde CL, Buckner FS, Fan E.

J Med Chem. 2012 Jul 26;55(14):6342-51. doi: 10.1021/jm300303e. Epub 2012 Jul 11.

15.

N-O chemistry for antibiotics: discovery of N-alkyl-N-(pyridin-2-yl)hydroxylamine scaffolds as selective antibacterial agents using nitroso Diels-Alder and ene chemistry.

Wencewicz TA, Yang B, Rudloff JR, Oliver AG, Miller MJ.

J Med Chem. 2011 Oct 13;54(19):6843-58. doi: 10.1021/jm200794r. Epub 2011 Sep 15.

16.

Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice.

Shibata S, Gillespie JR, Kelley AM, Napuli AJ, Zhang Z, Kovzun KV, Pefley RM, Lam J, Zucker FH, Van Voorhis WC, Merritt EA, Hol WG, Verlinde CL, Fan E, Buckner FS.

Antimicrob Agents Chemother. 2011 May;55(5):1982-9. doi: 10.1128/AAC.01796-10. Epub 2011 Jan 31.

17.

Challenges of antibacterial discovery.

Silver LL.

Clin Microbiol Rev. 2011 Jan;24(1):71-109. doi: 10.1128/CMR.00030-10. Review.

18.

Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate.

Larson ET, Kim JE, Zucker FH, Kelley A, Mueller N, Napuli AJ, Verlinde CL, Fan E, Buckner FS, Van Voorhis WC, Merritt EA, Hol WG.

Biochimie. 2011 Mar;93(3):570-82. doi: 10.1016/j.biochi.2010.11.015. Epub 2010 Dec 7.

19.

Crystallization of Mycobacterium smegmatis methionyl-tRNA synthetase in the presence of methionine and adenosine.

Ingvarsson H, Jones TA, Unge T.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jun 1;65(Pt 6):618-20. doi: 10.1107/S1744309109016704. Epub 2009 May 22.

20.

Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.

Green LS, Bullard JM, Ribble W, Dean F, Ayers DF, Ochsner UA, Janjic N, Jarvis TC.

Antimicrob Agents Chemother. 2009 Jan;53(1):86-94. doi: 10.1128/AAC.00275-08. Epub 2008 Nov 17.

Supplemental Content

Support Center