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TSPY1 suppresses USP7-mediated p53 function and promotes spermatogonial proliferation.

Shen Y, Tu W, Liu Y, Yang X, Dong Q, Yang B, Xu J, Yan Y, Pei X, Liu M, Xu W, Yang Y.

Cell Death Dis. 2018 May 10;9(5):542. doi: 10.1038/s41419-018-0589-7.


USP49 participates in the DNA damage response by forming a positive feedback loop with p53.

Tu R, Kang W, Yang X, Zhang Q, Xie X, Liu W, Zhang J, Zhang XD, Wang H, Du RL.

Cell Death Dis. 2018 May 10;9(5):553. doi: 10.1038/s41419-018-0475-3.


Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses.

Deng T, Yan G, Song X, Xie L, Zhou Y, Li J, Hu X, Li Z, Hu J, Zhang Y, Zhang H, Sun Y, Feng P, Wei D, Hu B, Liu J, Tan W, Ye M.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4678-4683. doi: 10.1073/pnas.1714938115. Epub 2018 Apr 16.


EBNA1: Oncogenic Activity, Immune Evasion and Biochemical Functions Provide Targets for Novel Therapeutic Strategies against Epstein-Barr Virus- Associated Cancers.

Wilson JB, Manet E, Gruffat H, Busson P, Blondel M, Fahraeus R.

Cancers (Basel). 2018 Apr 6;10(4). pii: E109. doi: 10.3390/cancers10040109. Review.


Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis.

Gupta I, Singh K, Varshney NK, Khan S.

Front Cell Dev Biol. 2018 Feb 9;6:11. doi: 10.3389/fcell.2018.00011. eCollection 2018. Review.


Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy.

Choudhry H, Zamzami MA, Omran Z, Wu W, Mousli M, Bronner C, Alhosin M.

Oncol Lett. 2018 Jan;15(1):3-10. doi: 10.3892/ol.2017.7290. Epub 2017 Oct 30.


Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60.

Wang F, Wang L, Wu J, Sokirniy I, Nguyen P, Bregnard T, Weinstock J, Mattern M, Bezsonova I, Hancock WW, Kumar S.

PLoS One. 2017 Dec 13;12(12):e0189744. doi: 10.1371/journal.pone.0189744. eCollection 2017.


Ticking time bombs: connections between circadian clocks and cancer.

Lamia KA.

F1000Res. 2017 Oct 30;6:1910. doi: 10.12688/f1000research.11770.1. eCollection 2017. Review.


Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice.

Tian H, Tackmann NR, Jin A, Zheng J, Zhang Y.

J Biol Chem. 2017 Dec 29;292(52):21614-21622. doi: 10.1074/jbc.RA117.000122. Epub 2017 Nov 9.


Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.

Lamberto I, Liu X, Seo HS, Schauer NJ, Iacob RE, Hu W, Das D, Mikhailova T, Weisberg EL, Engen JR, Anderson KC, Chauhan D, Dhe-Paganon S, Buhrlage SJ.

Cell Chem Biol. 2017 Dec 21;24(12):1490-1500.e11. doi: 10.1016/j.chembiol.2017.09.003. Epub 2017 Oct 19.


USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination.

Novellasdemunt L, Foglizzo V, Cuadrado L, Antas P, Kucharska A, Encheva V, Snijders AP, Li VSW.

Cell Rep. 2017 Oct 17;21(3):612-627. doi: 10.1016/j.celrep.2017.09.072.


Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.

Thakran P, Pandit PA, Datta S, Kolathur KK, Pleiss JA, Mishra SK.

EMBO J. 2018 Jan 4;37(1):89-101. doi: 10.15252/embj.201796751. Epub 2017 Sep 25.


Regulation of the cell cycle and centrosome biology by deubiquitylases.

Darling S, Fielding AB, Sabat-Pośpiech D, Prior IA, Coulson JM.

Biochem Soc Trans. 2017 Oct 15;45(5):1125-1136. doi: 10.1042/BST20170087. Epub 2017 Sep 12. Review.


Protein deubiquitinase USP7 is required for osteogenic differentiation of human adipose-derived stem cells.

Tang Y, Lv L, Li W, Zhang X, Jiang Y, Ge W, Zhou Y.

Stem Cell Res Ther. 2017 Aug 14;8(1):186. doi: 10.1186/s13287-017-0637-8.


Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.

Carr MI, Jones SN.

Transl Cancer Res. 2016 Dec;5(6):707-724. doi: 10.21037/tcr.2016.11.75.


Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.

Jiang L, Xiong J, Zhan J, Yuan F, Tang M, Zhang C, Cao Z, Chen Y, Lu X, Li Y, Wang H, Wang L, Wang J, Zhu WG, Wang H.

J Biol Chem. 2017 Aug 11;292(32):13296-13311. doi: 10.1074/jbc.M117.780130. Epub 2017 Jun 27.


A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.

Malenczyk K, Girach F, Szodorai E, Storm P, Segerstolpe Å, Tortoriello G, Schnell R, Mulder J, Romanov RA, Borók E, Piscitelli F, Di Marzo V, Szabó G, Sandberg R, Kubicek S, Lubec G, Hökfelt T, Wagner L, Groop L, Harkany T.

EMBO J. 2017 Jul 14;36(14):2107-2125. doi: 10.15252/embj.201695347. Epub 2017 Jun 21.


Cellular and disease functions of the Prader-Willi Syndrome gene MAGEL2.

Tacer KF, Potts PR.

Biochem J. 2017 Jun 16;474(13):2177-2190. doi: 10.1042/BCJ20160616. Review.


The Deubiquitinating Enzymes UBP12 and UBP13 Positively Regulate MYC2 Levels in Jasmonate Responses.

Jeong JS, Jung C, Seo JS, Kim JK, Chua NH.

Plant Cell. 2017 Jun;29(6):1406-1424. doi: 10.1105/tpc.17.00216. Epub 2017 May 23.


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