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Metformin Treatment for the Prevention and/or Treatment of Breast/Mammary Tumorigenesis.

Grossmann ME, Yang DQ, Guo Z, Potter DA, Cleary MP.

Curr Pharmacol Rep. 2015 Apr 1;1(5):312-323.


Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids.

Peart T, Ramos Valdes Y, Correa RJ, Fazio E, Bertrand M, McGee J, Préfontaine M, Sugimoto A, DiMattia GE, Shepherd TG.

Oncotarget. 2015 Sep 8;6(26):22424-38.


Feeding and Fasting Signals Converge on the LKB1-SIK3 Pathway to Regulate Lipid Metabolism in Drosophila.

Choi S, Lim DS, Chung J.

PLoS Genet. 2015 May 21;11(5):e1005263. doi: 10.1371/journal.pgen.1005263. eCollection 2015 May.


LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.

Walsh NC, Waters LR, Fowler JA, Lin M, Cunningham CR, Brooks DG, Rehg JE, Morse HC 3rd, Teitell MA.

EMBO Rep. 2015 Jun;16(6):753-68. doi: 10.15252/embr.201439505. Epub 2015 Apr 26.


A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.

Esteve-Puig R, Gil R, González-Sánchez E, Bech-Serra JJ, Grueso J, Hernández-Losa J, Moliné T, Canals F, Ferrer B, Cortés J, Bastian B, Ramón Y Cajal S, Martín-Caballero J, Flores JM, Vivancos A, García-Patos V, Recio JÁ.

PLoS Genet. 2014 Oct 16;10(10):e1004721. doi: 10.1371/journal.pgen.1004721. eCollection 2014 Oct.


Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.

Gan RY, Li HB.

Int J Mol Sci. 2014 Sep 19;15(9):16698-718. doi: 10.3390/ijms150916698. Review.


Crystallization and preliminary crystallographic analysis of the chimeric protein LKB1-14-3-3ζ.

Ding S, Zhou R, Zhu Y.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Dec;69(Pt 12):1371-3. doi: 10.1107/S1744309113029230. Epub 2013 Nov 29.


Phosphorylation of ASPP2 by RAS/MAPK pathway is critical for its full pro-apoptotic function.

Godin-Heymann N, Wang Y, Slee E, Lu X.

PLoS One. 2013 Dec 2;8(12):e82022. doi: 10.1371/journal.pone.0082022. eCollection 2013.


Dysregulation of mTOR activity through LKB1 inactivation.

Zhou W, Marcus AI, Vertino PM.

Chin J Cancer. 2013 Aug;32(8):427-33. doi: 10.5732/cjc.013.10086. Epub 2013 May 14. Review.


LKB1 and AMP-activated protein kinase: regulators of cell polarity.

Nakano A, Takashima S.

Genes Cells. 2012 Sep;17(9):737-47. doi: 10.1111/j.1365-2443.2012.01629.x. Epub 2012 Aug 14. Review.


The LKB1 complex-AMPK pathway: the tree that hides the forest.

Sebbagh M, Olschwang S, Santoni MJ, Borg JP.

Fam Cancer. 2011 Sep;10(3):415-24. doi: 10.1007/s10689-011-9457-7. Review.


LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection.

Cao Y, Li H, Liu H, Zhang M, Hua Z, Ji H, Liu X.

EMBO J. 2011 May 18;30(10):2083-93. doi: 10.1038/emboj.2011.116. Epub 2011 Apr 12.


The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice.

Saha PK, Reddy VT, Konopleva M, Andreeff M, Chan L.

J Biol Chem. 2010 Dec 24;285(52):40581-92. doi: 10.1074/jbc.M110.176545. Epub 2010 Oct 18.


Metastasis suppression by adiponectin: LKB1 rises up to the challenge.

Saxena NK, Sharma D.

Cell Adh Migr. 2010 Jul-Sep;4(3):358-62. Epub 2010 Jul 17.


ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.

Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4153-8. doi: 10.1073/pnas.0913860107. Epub 2010 Feb 16. Erratum in: Proc Natl Acad Sci U S A. 2012 May 22;109(21):8352.


Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.

Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM.

Science. 2009 Dec 18;326(5960):1707-11. doi: 10.1126/science.1178377. Epub 2009 Nov 5.


Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations.

Gruzman A, Babai G, Sasson S.

Rev Diabet Stud. 2009 Spring;6(1):13-36. doi: 10.1900/RDS.2009.6.13. Epub 2009 May 10.


Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways.

Zhou L, Deepa SS, Etzler JC, Ryu J, Mao X, Fang Q, Liu DD, Torres JM, Jia W, Lechleiter JD, Liu F, Dong LQ.

J Biol Chem. 2009 Aug 14;284(33):22426-35. doi: 10.1074/jbc.M109.028357. Epub 2009 Jun 11.

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