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Items: 1 to 20 of 361

1.

PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation.

Yang W, Wang X, Liu J, Duan C, Gao G, Lu L, Yu S, Yang H.

Oncotarget. 2017 Oct 6;9(1):37-53. doi: 10.18632/oncotarget.21554. eCollection 2018 Jan 2.

2.

The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint.

Kaindlstorfer C, Jellinger KA, Eschlböck S, Stefanova N, Weiss G, Wenning GK.

J Alzheimers Dis. 2018;61(4):1253-1273. doi: 10.3233/JAD-170601.

3.

Phosphorylated α-Synuclein-Copper Complex Formation in the Pathogenesis of Parkinson's Disease.

Castillo-Gonzalez JA, Loera-Arias MJ, Saucedo-Cardenas O, Montes-de-Oca-Luna R, Garcia-Garcia A, Rodriguez-Rocha H.

Parkinsons Dis. 2017;2017:9164754. doi: 10.1155/2017/9164754. Epub 2017 Nov 23. Review.

4.

Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies.

Refolo V, Bez F, Polissidis A, Kuzdas-Wood D, Sturm E, Kamaratou M, Poewe W, Stefanis L, Angela Cenci M, Romero-Ramos M, Wenning GK, Stefanova N.

Acta Neuropathol Commun. 2018 Jan 3;6(1):2. doi: 10.1186/s40478-017-0504-y.

5.

α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton.

Ordonez DG, Lee MK, Feany MB.

Neuron. 2018 Jan 3;97(1):108-124.e6. doi: 10.1016/j.neuron.2017.11.036. Epub 2017 Dec 14.

PMID:
29249285
6.

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.

Rey NL, George S, Steiner JA, Madaj Z, Luk KC, Trojanowski JQ, Lee VM, Brundin P.

Acta Neuropathol. 2018 Jan;135(1):65-83. doi: 10.1007/s00401-017-1792-9. Epub 2017 Dec 5.

7.

Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice.

Karampetsou M, Ardah MT, Semitekolou M, Polissidis A, Samiotaki M, Kalomoiri M, Majbour N, Xanthou G, El-Agnaf OMA, Vekrellis K.

Sci Rep. 2017 Nov 28;7(1):16533. doi: 10.1038/s41598-017-15813-8.

8.

Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport.

Toba S, Jin M, Yamada M, Kumamoto K, Matsumoto S, Yasunaga T, Fukunaga Y, Miyazawa A, Fujita S, Itoh K, Fushiki S, Kojima H, Wanibuchi H, Arai Y, Nagai T, Hirotsune S.

Sci Rep. 2017 Nov 27;7(1):16386. doi: 10.1038/s41598-017-15575-3.

9.

α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin.

Lieberman OJ, Choi SJ, Kanter E, Saverchenko A, Frier MD, Fiore GM, Wu M, Kondapalli J, Zampese E, Surmeier DJ, Sulzer D, Mosharov EV.

eNeuro. 2017 Nov 21;4(6). pii: ENEURO.0167-17.2017. doi: 10.1523/ENEURO.0167-17.2017. eCollection 2017 Nov-Dec.

10.

α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration.

Harms AS, Delic V, Thome AD, Bryant N, Liu Z, Chandra S, Jurkuvenaite A, West AB.

Acta Neuropathol Commun. 2017 Nov 21;5(1):85. doi: 10.1186/s40478-017-0494-9.

11.

c-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential.

Brahmachari S, Karuppagounder SS, Ge P, Lee S, Dawson VL, Dawson TM, Ko HS.

J Parkinsons Dis. 2017;7(4):589-601. doi: 10.3233/JPD-171191.

12.

Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity.

Bobela W, Nazeeruddin S, Knott G, Aebischer P, Schneider BL.

Mol Neurodegener. 2017 Nov 3;12(1):80. doi: 10.1186/s13024-017-0220-x.

13.

Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson's disease.

Vicente Miranda H, Cássio R, Correia-Guedes L, Gomes MA, Chegão A, Miranda E, Soares T, Coelho M, Rosa MM, Ferreira JJ, Outeiro TF.

Sci Rep. 2017 Oct 20;7(1):13713. doi: 10.1038/s41598-017-14175-5.

14.

Critical appraisal of pathology transmission in the α-synuclein fibril model of Lewy body disorders.

Nouraei N, Mason DM, Miner KM, Carcella MA, Bhatia TN, Dumm BK, Soni D, Johnson DA, Luk KC, Leak RK.

Exp Neurol. 2018 Jan;299(Pt A):172-196. doi: 10.1016/j.expneurol.2017.10.017. Epub 2017 Oct 19.

PMID:
29056362
15.

Mitophagy in Parkinson's Disease: Pathogenic and Therapeutic Implications.

Gao F, Yang J, Wang D, Li C, Fu Y, Wang H, He W, Zhang J.

Front Neurol. 2017 Oct 4;8:527. doi: 10.3389/fneur.2017.00527. eCollection 2017. Review.

16.

Neuroprotective effect of chondroitin sulfate on SH‑SY5Y cells overexpressing wild‑type or A53T mutant α‑synuclein.

Ju C, Gao J, Hou L, Wang L, Zhang F, Sun F, Zhang T, Xu P, Shi Z, Hu F, Zhang C.

Mol Med Rep. 2017 Dec;16(6):8721-8728. doi: 10.3892/mmr.2017.7725. Epub 2017 Oct 4.

17.

Current concepts and controversies in the pathogenesis of Parkinson's disease dementia and Dementia with Lewy Bodies.

Weil RS, Lashley TL, Bras J, Schrag AE, Schott JM.

F1000Res. 2017 Aug 30;6:1604. doi: 10.12688/f1000research.11725.1. eCollection 2017. Review.

18.

Membrane Binding of Parkinson's Protein α-Synuclein: Effect of Phosphorylation at Positions 87 and 129 by the S to D Mutation Approach.

Kumar P, Schilderink N, Subramaniam V, Huber M.

Isr J Chem. 2017 Jul;57(7-8):762-770. doi: 10.1002/ijch.201600083. Epub 2016 Nov 10.

19.

E46K α-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation.

Íñigo-Marco I, Valencia M, Larrea L, Bugallo R, Martínez-Goikoetxea M, Zuriguel I, Arrasate M.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8274-E8283. doi: 10.1073/pnas.1703420114. Epub 2017 Sep 12.

PMID:
28900007
20.

Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease.

Santos AL, Lindner AB.

Oxid Med Cell Longev. 2017;2017:5716409. doi: 10.1155/2017/5716409. Epub 2017 Aug 15. Review.

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