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Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer.

De Marco C, Laudanna C, Rinaldo N, Oliveira DM, Ravo M, Weisz A, Ceccarelli M, Caira E, Rizzuto A, Zoppoli P, Malanga D, Viglietto G.

PLoS One. 2017 Jun 29;12(6):e0178865. doi: 10.1371/journal.pone.0178865. eCollection 2017.


In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface.

Bestgen B, Belaid-Choucair Z, Lomberget T, Le Borgne M, Filhol O, Cochet C.

Pharmaceuticals (Basel). 2017 Feb 3;10(1). pii: E16. doi: 10.3390/ph10010016.


Up-regulation of miR-95-3p in hepatocellular carcinoma promotes tumorigenesis by targeting p21 expression.

Ye J, Yao Y, Song Q, Li S, Hu Z, Yu Y, Hu C, Da X, Li H, Chen Q, Wang QK.

Sci Rep. 2016 Oct 4;6:34034. doi: 10.1038/srep34034.


Mitomycin C and decarbamoyl mitomycin C induce p53-independent p21WAF1/CIP1 activation.

Cheng SY, Seo J, Huang BT, Napolitano T, Champeil E.

Int J Oncol. 2016 Nov;49(5):1815-1824. doi: 10.3892/ijo.2016.3703. Epub 2016 Sep 23.


Familial Alzheimer's Disease Lymphocytes Respond Differently Than Sporadic Cells to Oxidative Stress: Upregulated p53-p21 Signaling Linked with Presenilin 1 Mutants.

Wojsiat J, Laskowska-Kaszub K, Alquézar C, Białopiotrowicz E, Esteras N, Zdioruk M, Martin-Requero A, Wojda U.

Mol Neurobiol. 2017 Sep;54(7):5683-5698. doi: 10.1007/s12035-016-0105-y. Epub 2016 Sep 19.


SCFFbl12 Increases p21Waf1/Cip1 Expression Level through Atypical Ubiquitin Chain Synthesis.

Tsuruta F, Takebe A, Haratake K, Kanemori Y, Kim J, Endo T, Kigoshi Y, Fukuda T, Miyahara H, Ebina M, Baba T, Chiba T.

Mol Cell Biol. 2016 Jul 29;36(16):2182-94. doi: 10.1128/MCB.00174-16. Print 2016 Aug 15.


Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.

Lien EC, Lyssiotis CA, Juvekar A, Hu H, Asara JM, Cantley LC, Toker A.

Nat Cell Biol. 2016 May;18(5):572-8. doi: 10.1038/ncb3341. Epub 2016 Apr 18.


Down-regulation of hTERT and Cyclin D1 transcription via PI3K/Akt and TGF-β pathways in MCF-7 Cancer cells with PX-866 and Raloxifene.

Peek GW, Tollefsbol TO.

Exp Cell Res. 2016 May 15;344(1):95-102. doi: 10.1016/j.yexcr.2016.03.022. Epub 2016 Mar 23.


PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells.

Samarin J, Laketa V, Malz M, Roessler S, Stein I, Horwitz E, Singer S, Dimou E, Cigliano A, Bissinger M, Falk CS, Chen X, Dooley S, Pikarsky E, Calvisi DF, Schultz C, Schirmacher P, Breuhahn K.

Hepatology. 2016 Mar;63(3):813-26. doi: 10.1002/hep.28357. Epub 2016 Jan 14.


Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration.

Cohen DP, Martignetti L, Robine S, Barillot E, Zinovyev A, Calzone L.

PLoS Comput Biol. 2015 Nov 3;11(11):e1004571. doi: 10.1371/journal.pcbi.1004571. eCollection 2015 Nov.


The Emerging Regulation of VEGFR-2 in Triple-Negative Breast Cancer.

Zhu X, Zhou W.

Front Endocrinol (Lausanne). 2015 Oct 9;6:159. doi: 10.3389/fendo.2015.00159. eCollection 2015. Review.


AML sensitivity to YM155 is modulated through AKT and Mcl-1.

de Necochea-Campion R, Diaz Osterman CJ, Hsu HW, Fan J, Mirshahidi S, Wall NR, Chen CS.

Cancer Lett. 2015 Sep 28;366(1):44-51. doi: 10.1016/j.canlet.2015.05.034. Epub 2015 Jun 25.


AMP-18 Targets p21 to Maintain Epithelial Homeostasis.

Chen P, Li YC, Toback FG.

PLoS One. 2015 Apr 28;10(4):e0125490. doi: 10.1371/journal.pone.0125490. eCollection 2015.


Loss of p21Cip1/CDKN1A renders cancer cells susceptible to Polo-like kinase 1 inhibition.

Kreis NN, Louwen F, Zimmer B, Yuan J.

Oncotarget. 2015 Mar 30;6(9):6611-26.


Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways.

Zhao B, Zhao W, Wang Y, Xu Y, Xu J, Tang K, Zhang S, Yin Z, Wu Q, Wang X.

Oncotarget. 2015 Apr 30;6(12):10116-33.


Cytoplasmic localization of p21 protects trophoblast giant cells from DNA damage induced apoptosis.

de Renty C, DePamphilis ML, Ullah Z.

PLoS One. 2014 May 21;9(5):e97434. doi: 10.1371/journal.pone.0097434. eCollection 2014.


Identification of herpesvirus proteins that contribute to G1/S arrest.

Paladino P, Marcon E, Greenblatt J, Frappier L.

J Virol. 2014 Apr;88(8):4480-92. doi: 10.1128/JVI.00059-14. Epub 2014 Feb 5.


Epidermal growth factor receptor (EGFR) polymorphisms and breast cancer among Hispanic and non-Hispanic white women: the Breast Cancer Health Disparities Study.

Connor AE, Baumgartner RN, Baumgartner KB, Pinkston CM, John EM, Torres-Mejía G, Hines LM, Giuliano AR, Wolff RK, Slattery ML.

Int J Mol Epidemiol Genet. 2013 Nov 28;4(4):235-49. eCollection 2013.

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