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Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats.

Yang HJ, Zhang HY, Bi GH, He Y, Gao JT, Xi ZX.

Cell Rep. 2017 Jul 11;20(2):319-332. doi: 10.1016/j.celrep.2017.06.046.


N-acetylaspartylglutamate Inhibits Heroin Self-Administration and Heroin-Seeking Behaviors Induced by Cue or Priming in Rats.

Zhu H, Lai M, Chen W, Mei D, Zhang F, Liu H, Zhou W.

Neurosci Bull. 2017 Aug;33(4):396-404. doi: 10.1007/s12264-017-0140-3. Epub 2017 May 22.


Fast-acting antidepressants rapidly stimulate ERK signaling and BDNF release in primary neuronal cultures.

Lepack AE, Bang E, Lee B, Dwyer JM, Duman RS.

Neuropharmacology. 2016 Dec;111:242-252. doi: 10.1016/j.neuropharm.2016.09.011. Epub 2016 Sep 12.


The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis.

Scofield MD, Heinsbroek JA, Gipson CD, Kupchik YM, Spencer S, Smith AC, Roberts-Wolfe D, Kalivas PW.

Pharmacol Rev. 2016 Jul;68(3):816-71. doi: 10.1124/pr.116.012484. Review.


Pituitary Adenylate cyclase-activating polypeptide orchestrates neuronal regulation of the astrocytic glutamate-releasing mechanism system xc (.).

Kong L, Albano R, Madayag A, Raddatz N, Mantsch JR, Choi S, Lobner D, Baker DA.

J Neurochem. 2016 May;137(3):384-93. doi: 10.1111/jnc.13566. Epub 2016 Mar 1.


N-acetylcysteine decreased nicotine reward-like properties and withdrawal in mice.

Bowers MS, Jackson A, Maldoon PP, Damaj MI.

Psychopharmacology (Berl). 2016 Mar;233(6):995-1003. doi: 10.1007/s00213-015-4179-4. Epub 2015 Dec 17.


Nucleus accumbens injections of the mGluR2/3 agonist LY379268 increase cue-induced sucrose seeking following adult, but not adolescent sucrose self-administration.

Myal S, O'Donnell P, Counotte DS.

Neuroscience. 2015 Oct 1;305:309-15. doi: 10.1016/j.neuroscience.2015.07.077. Epub 2015 Aug 1.


Differential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on nicotine versus cocaine self-administration and relapse in squirrel monkeys.

Justinova Z, Le Foll B, Redhi GH, Markou A, Goldberg SR.

Psychopharmacology (Berl). 2016 May;233(10):1791-800. doi: 10.1007/s00213-015-3994-y. Epub 2015 Jul 8.


Constitutive activity of metabotropic glutamate receptor 7.

Kammermeier PJ.

BMC Neurosci. 2015 Mar 24;16:17. doi: 10.1186/s12868-015-0154-6.


The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys.

Justinova Z, Panlilio LV, Secci ME, Redhi GH, Schindler CW, Cross AJ, Mrzljak L, Medd A, Shaham Y, Goldberg SR.

Biol Psychiatry. 2015 Oct 1;78(7):452-62. doi: 10.1016/j.biopsych.2015.01.014. Epub 2015 Feb 7.


Direct hypothalamic and indirect trans-pallidal, trans-thalamic, or trans-septal control of accumbens signaling and their roles in food intake.

Urstadt KR, Stanley BG.

Front Syst Neurosci. 2015 Feb 13;9:8. doi: 10.3389/fnsys.2015.00008. eCollection 2015. Review.


Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence.

Dhanya RP, Sheffler DJ, Dahl R, Davis M, Lee PS, Yang L, Nickols HH, Cho HP, Smith LH, D'Souza MS, Conn PJ, Der-Avakian A, Markou A, Cosford ND.

J Med Chem. 2014 May 22;57(10):4154-72. doi: 10.1021/jm5000563. Epub 2014 May 9.


Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.

Lane TA, Boerner T, Bannerman DM, Kew JN, Tunbridge EM, Sharp T, Harrison PJ.

BMC Neurosci. 2013 Sep 22;14:102. doi: 10.1186/1471-2202-14-102.


The group II metabotropic glutamate receptor agonist, LY379268, decreases methamphetamine self-administration in rats.

Crawford JT, Roberts DC, Beveridge TJ.

Drug Alcohol Depend. 2013 Oct 1;132(3):414-9. doi: 10.1016/j.drugalcdep.2013.07.024. Epub 2013 Aug 2.


NAAG peptidase inhibitor improves motor function and reduces cognitive dysfunction in a model of TBI with secondary hypoxia.

Gurkoff GG, Feng JF, Van KC, Izadi A, Ghiasvand R, Shahlaie K, Song M, Lowe DA, Zhou J, Lyeth BG.

Brain Res. 2013 Jun 17;1515:98-107. doi: 10.1016/j.brainres.2013.03.043. Epub 2013 Apr 3.


Activation of mammalian target of rapamycin and synaptogenesis: role in the actions of rapid-acting antidepressants.

Dwyer JM, Duman RS.

Biol Psychiatry. 2013 Jun 15;73(12):1189-98. doi: 10.1016/j.biopsych.2012.11.011. Epub 2013 Jan 4. Review.


Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence.

Sidique S, Dhanya RP, Sheffler DJ, Nickols HH, Yang L, Dahl R, Mangravita-Novo A, Smith LH, D'Souza MS, Semenova S, Conn PJ, Markou A, Cosford ND.

J Med Chem. 2012 Nov 26;55(22):9434-45. doi: 10.1021/jm3005306. Epub 2012 Oct 23.


Mechanisms of psychostimulant-induced structural plasticity.

Golden SA, Russo SJ.

Cold Spring Harb Perspect Med. 2012 Oct 1;2(10). pii: a011957. doi: 10.1101/cshperspect.a011957.


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