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DNA-PKcs, Allostery, and DNA Double-Strand Break Repair: Defining the Structure and Setting the Stage.

Chirgadze DY, Ascher DB, Blundell TL, Sibanda BL.

Methods Enzymol. 2017;592:145-157. doi: 10.1016/bs.mie.2017.04.001. Epub 2017 May 3.


Multimerization properties of PiggyMac, a domesticated piggyBac transposase involved in programmed genome rearrangements.

Dubois E, Mathy N, Régnier V, Bischerour J, Baudry C, Trouslard R, Bétermier M.

Nucleic Acids Res. 2017 Apr 7;45(6):3204-3216. doi: 10.1093/nar/gkw1359.


PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice.

Liu X, Shao Z, Jiang W, Lee BJ, Zha S.

Nat Commun. 2017 Jan 4;8:13816. doi: 10.1038/ncomms13816.


An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex.

Hammel M, Yu Y, Radhakrishnan SK, Chokshi C, Tsai MS, Matsumoto Y, Kuzdovich M, Remesh SG, Fang S, Tomkinson AE, Lees-Miller SP, Tainer JA.

J Biol Chem. 2016 Dec 30;291(53):26987-27006. doi: 10.1074/jbc.M116.751867. Epub 2016 Nov 14.


Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency.

Chang HH, Watanabe G, Gerodimos CA, Ochi T, Blundell TL, Jackson SP, Lieber MR.

J Biol Chem. 2016 Nov 18;291(47):24377-24389. Epub 2016 Oct 4.


Cloning, localization and focus formation at DNA damage sites of canine XRCC4.

Koike M, Yutoku Y, Koike A.

J Vet Med Sci. 2017 Jan 10;78(12):1865-1871. doi: 10.1292/jvms.16-0381. Epub 2016 Sep 18.


Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface.

Menchon G, Bombarde O, Trivedi M, Négrel A, Inard C, Giudetti B, Baltas M, Milon A, Modesti M, Czaplicki G, Calsou P.

Sci Rep. 2016 Mar 11;6:22878. doi: 10.1038/srep22878.


A composite approach towards a complete model of the myosin rod.

Korkmaz EN, Taylor KC, Andreas MP, Ajay G, Heinze NT, Cui Q, Rayment I.

Proteins. 2016 Jan;84(1):172-189. doi: 10.1002/prot.24964. Epub 2015 Dec 9.


Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors.

Blaszczyk M, Harmer NJ, Chirgadze DY, Ascher DB, Blundell TL.

Prog Biophys Mol Biol. 2015 Sep;118(3):103-11. doi: 10.1016/j.pbiomolbio.2015.04.007. Epub 2015 May 5. Review.


Mutations in the NHEJ component XRCC4 cause primordial dwarfism.

Murray JE, van der Burg M, IJspeert H, Carroll P, Wu Q, Ochi T, Leitch A, Miller ES, Kysela B, Jawad A, Bottani A, Brancati F, Cappa M, Cormier-Daire V, Deshpande C, Faqeih EA, Graham GE, Ranza E, Blundell TL, Jackson AP, Stewart GS, Bicknell LS.

Am J Hum Genet. 2015 Mar 5;96(3):412-24. doi: 10.1016/j.ajhg.2015.01.013. Epub 2015 Feb 26.


Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.

Xing M, Yang M, Huo W, Feng F, Wei L, Jiang W, Ning S, Yan Z, Li W, Wang Q, Hou M, Dong C, Guo R, Gao G, Ji J, Zha S, Lan L, Liang H, Xu D.

Nat Commun. 2015 Feb 11;6:6233. doi: 10.1038/ncomms7233.


DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.

Ochi T, Blackford AN, Coates J, Jhujh S, Mehmood S, Tamura N, Travers J, Wu Q, Draviam VM, Robinson CV, Blundell TL, Jackson SP.

Science. 2015 Jan 9;347(6218):185-188. doi: 10.1126/science.1261971.


A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization.

He M, Hu X, Chen L, Cao AY, Yu KD, Shi TY, Kuang XY, Shi WB, Ling H, Li S, Qiao F, Yao L, Wei Q, Di GH, Shao ZM.

Oncotarget. 2014 Dec 15;5(23):12218-32.


DNA double strand break repair in mitosis is suppressed by phosphorylation of XRCC4.

Lees-Miller SP.

PLoS Genet. 2014 Aug 28;10(8):e1004598. doi: 10.1371/journal.pgen.1004598. eCollection 2014 Aug. No abstract available.


Recognition and repair of chemically heterogeneous structures at DNA ends.

Andres SN, Schellenberg MJ, Wallace BD, Tumbale P, Williams RS.

Environ Mol Mutagen. 2015 Jan;56(1):1-21. doi: 10.1002/em.21892. Epub 2014 Aug 11. Review.


Genome-wide screens for sensitivity to ionizing radiation identify the fission yeast nonhomologous end joining factor Xrc4.

Li J, Yu Y, Suo F, Sun LL, Zhao D, Du LL.

G3 (Bethesda). 2014 May 21;4(7):1297-306. doi: 10.1534/g3.114.011841.


Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time.

Williams GJ, Hammel M, Radhakrishnan SK, Ramsden D, Lees-Miller SP, Tainer JA.

DNA Repair (Amst). 2014 May;17:110-20. doi: 10.1016/j.dnarep.2014.02.009. Epub 2014 Mar 20. Review.


The spatial organization of non-homologous end joining: from bridging to end joining.

Ochi T, Wu Q, Blundell TL.

DNA Repair (Amst). 2014 May;17:98-109. doi: 10.1016/j.dnarep.2014.02.010. Epub 2014 Mar 11.


Nonhomologous end joining: a good solution for bad ends.

Waters CA, Strande NT, Wyatt DW, Pryor JM, Ramsden DA.

DNA Repair (Amst). 2014 May;17:39-51. doi: 10.1016/j.dnarep.2014.02.008. Epub 2014 Mar 14. Review.


DNA repair pathways in trypanosomatids: from DNA repair to drug resistance.

Genois MM, Paquet ER, Laffitte MC, Maity R, Rodrigue A, Ouellette M, Masson JY.

Microbiol Mol Biol Rev. 2014 Mar;78(1):40-73. doi: 10.1128/MMBR.00045-13. Review.

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