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Items: 1 to 20 of 24


A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation.

Grassilli E, Pisano F, Cialdella A, Bonomo S, Missaglia C, Cerrito MG, Masiero L, Ianzano L, Giordano F, Cicirelli V, Narloch R, D'Amato F, Noli B, Ferri GL, Leone BE, Stanta G, Bonin S, Helin K, Giovannoni R, Lavitrano M.

Oncogene. 2016 Aug 18;35(33):4368-78. doi: 10.1038/onc.2015.504.


Exploration of Novel Inhibitors for Bruton's Tyrosine Kinase by 3D QSAR Modeling and Molecular Dynamics Simulation.

Bavi R, Kumar R, Choi L, Woo Lee K.

PLoS One. 2016 Jan 19;11(1):e0147190. doi: 10.1371/journal.pone.0147190.


Protein kinase C in the immune system: from signalling to chromatin regulation.

Lim PS, Sutton CR, Rao S.

Immunology. 2015 Dec;146(4):508-22. doi: 10.1111/imm.12510. Review.


Irreversible dual inhibitory mode: the novel Btk inhibitor PLS-123 demonstrates promising anti-tumor activity in human B-cell lymphoma.

Ding N, Li X, Shi Y, Ping L, Wu L, Fu K, Feng L, Zheng X, Song Y, Pan Z, Zhu J.

Oncotarget. 2015 Jun 20;6(17):15122-36.


Protein kinase C in cellular transformation: a valid target for therapy?

Tarafdar A, Michie AM.

Biochem Soc Trans. 2014 Dec;42(6):1556-62. doi: 10.1042/BST20140255. Review.


Does B cell receptor signaling in chronic lymphocytic leukaemia cells differ from that in other B cell types?

Slupsky JR.

Scientifica (Cairo). 2014;2014:208928. doi: 10.1155/2014/208928. Review.


Ibrutinib and novel BTK inhibitors in clinical development.

Akinleye A, Chen Y, Mukhi N, Song Y, Liu D.

J Hematol Oncol. 2013 Aug 19;6:59. doi: 10.1186/1756-8722-6-59. Review.


Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3ζ, regulates shuttling, and attenuates both tonic and induced signaling in B cells.

Mohammad DK, Nore BF, Hussain A, Gustafsson MO, Mohamed AJ, Smith CI.

Mol Cell Biol. 2013 Aug;33(16):3214-26. doi: 10.1128/MCB.00247-13.


Involvement of distinct PKC gene products in T cell functions.

Pfeifhofer-Obermair C, Thuille N, Baier G.

Front Immunol. 2012 Aug 6;3:220. doi: 10.3389/fimmu.2012.00220.


Identification of autoantibody biomarkers for primary Sjögren's syndrome using protein microarrays.

Hu S, Vissink A, Arellano M, Roozendaal C, Zhou H, Kallenberg CG, Wong DT.

Proteomics. 2011 Apr;11(8):1499-507. doi: 10.1002/pmic.201000206.


Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes.

Moreno-García ME, Sommer K, Haftmann C, Sontheimer C, Andrews SF, Rawlings DJ.

J Immunol. 2009 Dec 1;183(11):7362-70. doi: 10.4049/jimmunol.0902438.


B-lymphocyte calcium influx.

King LB, Freedman BD.

Immunol Rev. 2009 Sep;231(1):265-77. doi: 10.1111/j.1600-065X.2009.00822.x. Review.


The tyrosine kinase network regulating mast cell activation.

Gilfillan AM, Rivera J.

Immunol Rev. 2009 Mar;228(1):149-69. doi: 10.1111/j.1600-065X.2008.00742.x. Review.


Diacylglycerol kinases in immune cell function and self-tolerance.

Zhong XP, Guo R, Zhou H, Liu C, Wan CK.

Immunol Rev. 2008 Aug;224:249-64. doi: 10.1111/j.1600-065X.2008.00647.x. Review.


Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells.

Olenchock BA, Guo R, Silverman MA, Wu JN, Carpenter JH, Koretzky GA, Zhong XP.

J Exp Med. 2006 Jun 12;203(6):1471-80.


Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.

Kim YJ, Sekiya F, Poulin B, Bae YS, Rhee SG.

Mol Cell Biol. 2004 Nov;24(22):9986-99.


A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation.

Guo S, Ferl GZ, Deora R, Riedinger M, Yin S, Kerwin JL, Loo JA, Witte ON.

Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14180-5.


Emerging and diverse roles of protein kinase C in immune cell signalling.

Tan SL, Parker PJ.

Biochem J. 2003 Dec 15;376(Pt 3):545-52. Review.


Conformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering.

Márquez JA, Smith CI, Petoukhov MV, Lo Surdo P, Mattsson PT, Knekt M, Westlund A, Scheffzek K, Saraste M, Svergun DI.

EMBO J. 2003 Sep 15;22(18):4616-24.

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