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Items: 20


Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.

Ong HB, Lee WS, Patterson S, Wyllie S, Fairlamb AH.

Mol Microbiol. 2015 Jan;95(1):143-56. doi: 10.1111/mmi.12853. Epub 2014 Nov 25.


pH-rate profiles support a general base mechanism for galactokinase (Lactococcus lactis).

Reinhardt LA, Thoden JB, Peters GS, Holden HM, Cleland WW.

FEBS Lett. 2013 Sep 2;587(17):2876-81. doi: 10.1016/j.febslet.2013.07.017. Epub 2013 Jul 19.


Biochemical characterization of pantoate kinase, a novel enzyme necessary for coenzyme A biosynthesis in the Archaea.

Tomita H, Yokooji Y, Ishibashi T, Imanaka T, Atomi H.

J Bacteriol. 2012 Oct;194(19):5434-43. doi: 10.1128/JB.06624-11. Epub 2012 Aug 3.


Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.

Barta ML, McWhorter WJ, Miziorko HM, Geisbrecht BV.

Biochemistry. 2012 Jul 17;51(28):5611-21. Epub 2012 Jul 6.


The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation.

Lavy T, Kumar PR, He H, Joshua-Tor L.

Genes Dev. 2012 Feb 1;26(3):294-303. doi: 10.1101/gad.182691.111.


Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria.

Tang M, Odejinmi SI, Allette YM, Vankayalapati H, Lai K.

Bioorg Med Chem. 2011 Oct 1;19(19):5886-95. doi: 10.1016/j.bmc.2011.08.012. Epub 2011 Aug 16.


Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis.

Barta ML, Skaff DA, McWhorter WJ, Herdendorf TJ, Miziorko HM, Geisbrecht BV.

J Biol Chem. 2011 Jul 8;286(27):23900-10. doi: 10.1074/jbc.M111.242016. Epub 2011 May 11.


The intrinsic reactivity of ATP and the catalytic proficiencies of kinases acting on glucose, N-acetylgalactosamine, and homoserine: a thermodynamic analysis.

Stockbridge RB, Wolfenden R.

J Biol Chem. 2009 Aug 21;284(34):22747-57. doi: 10.1074/jbc.M109.017806. Epub 2009 Jun 15.


Kinetic and functional analysis of L-threonine kinase, the PduX enzyme of Salmonella enterica.

Fan C, Fromm HJ, Bobik TA.

J Biol Chem. 2009 Jul 24;284(30):20240-8. doi: 10.1074/jbc.M109.027425. Epub 2009 Jun 9.


Structure of the ternary complex of phosphomevalonate kinase: the enzyme and its family.

Andreassi JL 2nd, Vetting MW, Bilder PW, Roderick SL, Leyh TS.

Biochemistry. 2009 Jul 14;48(27):6461-8. doi: 10.1021/bi900537u.


The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.

Eoh H, Brennan PJ, Crick DC.

Tuberculosis (Edinb). 2009 Jan;89(1):1-11. doi: 10.1016/ Epub 2008 Sep 14. Review.


Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery.

Sgraja T, Alphey MS, Ghilagaber S, Marquez R, Robertson MN, Hemmings JL, Lauw S, Rohdich F, Bacher A, Eisenreich W, Illarionova V, Hunter WN.

FEBS J. 2008 Jun;275(11):2779-94. doi: 10.1111/j.1742-4658.2008.06418.x. Epub 2008 Apr 16.


Genetic evidence for sites of interaction between the Gal3 and Gal80 proteins of the Saccharomyces cerevisiae GAL gene switch.

Diep CQ, Tao X, Pilauri V, Losiewicz M, Blank TE, Hopper JE.

Genetics. 2008 Feb;178(2):725-36. doi: 10.1534/genetics.107.074799. Epub 2008 Feb 3.


Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate.

Andreassi JL 2nd, Bilder PW, Vetting MW, Roderick SL, Leyh TS.

Protein Sci. 2007 May;16(5):983-9. Epub 2007 Mar 30.


Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase.

Sgraja T, Smith TK, Hunter WN.

BMC Struct Biol. 2007 Mar 30;7:20.


A preliminary crystallographic analysis of the putative mevalonate diphosphate decarboxylase from Trypanosoma brucei.

Byres E, Martin DM, Hunter WN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 1;61(Pt 6):581-4. Epub 2005 Jun 1.


Enterococcus faecalis phosphomevalonate kinase.

Doun SS, Burgner JW 2nd, Briggs SD, Rodwell VW.

Protein Sci. 2005 May;14(5):1134-9. Epub 2005 Mar 31.


Biosynthesis of isoprenoids: crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase.

Miallau L, Alphey MS, Kemp LE, Leonard GA, McSweeney SM, Hecht S, Bacher A, Eisenreich W, Rohdich F, Hunter WN.

Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9173-8. Epub 2003 Jul 23.


XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators.

Luz JG, Hassig CA, Pickle C, Godzik A, Meyer BJ, Wilson IA.

Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 2.

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