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Somatic growth, aging, and longevity.

Bartke A.

NPJ Aging Mech Dis. 2017 Sep 29;3:14. doi: 10.1038/s41514-017-0014-y. eCollection 2017. Review.


Growth Hormone's Effect on Adipose Tissue: Quality versus Quantity.

Berryman DE, List EO.

Int J Mol Sci. 2017 Jul 26;18(8). pii: E1621. doi: 10.3390/ijms18081621. Review.


Delaying aging is neuroprotective in Parkinson's disease: a genetic analysis in C. elegans models.

Cooper JF, Dues DJ, Spielbauer KK, Machiela E, Senchuk MM, Van Raamsdonk JM.

NPJ Parkinsons Dis. 2015 Nov 19;1:15022. doi: 10.1038/npjparkd.2015.22. eCollection 2015.


Longevity is impacted by growth hormone action during early postnatal period.

Sun LY, Fang Y, Patki A, Koopman JJ, Allison DB, Hill CM, Masternak MM, Darcy J, Wang J, McFadden S, Bartke A.

Elife. 2017 Jul 4;6. pii: e24059. doi: 10.7554/eLife.24059.


Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan.

Merry TL, Kuhlow D, Laube B, Pöhlmann D, Pfeiffer AFH, Kahn CR, Ristow M, Zarse K.

Aging Cell. 2017 Aug;16(4):761-772. doi: 10.1111/acel.12610. Epub 2017 May 22.


GH and ageing: Pitfalls and new insights.

Bartke A, Darcy J.

Best Pract Res Clin Endocrinol Metab. 2017 Feb;31(1):113-125. doi: 10.1016/j.beem.2017.02.005. Epub 2017 Feb 24. Review.


Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan.

Pickering AM, Lehr M, Gendron CM, Pletcher SD, Miller RA.

Aging Cell. 2017 Aug;16(4):683-692. doi: 10.1111/acel.12596. Epub 2017 May 5.


Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons.

Cady G, Landeryou T, Garratt M, Kopchick JJ, Qi N, Garcia-Galiano D, Elias CF, Myers MG Jr, Miller RA, Sandoval DA, Sadagurski M.

Mol Metab. 2017 Mar 16;6(5):393-405. doi: 10.1016/j.molmet.2017.03.001. eCollection 2017 May.


Functionally enhanced brown adipose tissue in Ames dwarf mice.

Darcy J, Bartke A.

Adipocyte. 2017 Jan 2;6(1):62-67. doi: 10.1080/21623945.2016.1274470. Epub 2016 Dec 21.


Developments in our understanding of the effects of growth hormone on white adipose tissue from mice: implications to the clinic.

Berryman DE, Henry B, Hjortebjerg R, List EO, Kopchick JJ.

Expert Rev Endocrinol Metab. 2016;11(2):197-207. doi: 10.1586/17446651.2016.1147950. Epub 2016 Feb 24.


Altered structure and function of adipose tissue in long-lived mice with growth hormone-related mutations.

Darcy J, McFadden S, Bartke A.

Adipocyte. 2017 Apr 3;6(2):69-75. doi: 10.1080/21623945.2017.1308990. Epub 2017 Mar 21. Review.


Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions.

Petkovich DA, Podolskiy DI, Lobanov AV, Lee SG, Miller RA, Gladyshev VN.

Cell Metab. 2017 Apr 4;25(4):954-960.e6. doi: 10.1016/j.cmet.2017.03.016.


The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer.

Podlutsky A, Valcarcel-Ares MN, Yancey K, Podlutskaya V, Nagykaldi E, Gautam T, Miller RA, Sonntag WE, Csiszar A, Ungvari Z.

Geroscience. 2017 Apr;39(2):147-160. doi: 10.1007/s11357-017-9966-x. Epub 2017 Feb 23.


Evidence that a mitochondrial death spiral underlies antagonistic pleiotropy.

Stern M.

Aging Cell. 2017 Jun;16(3):435-443. doi: 10.1111/acel.12579. Epub 2017 Feb 9. Review.


Lipidome determinants of maximal lifespan in mammals.

Bozek K, Khrameeva EE, Reznick J, Omerbašić D, Bennett NC, Lewin GR, Azpurua J, Gorbunova V, Seluanov A, Regnard P, Wanert F, Marchal J, Pifferi F, Aujard F, Liu Z, Shi P, Pääbo S, Schroeder F, Willmitzer L, Giavalisco P, Khaitovich P.

Sci Rep. 2017 Jan 31;7(1):5. doi: 10.1038/s41598-017-00037-7.


Different Mechanisms of Longevity in Long-Lived Mouse and Caenorhabditis elegans Mutants Revealed by Statistical Analysis of Mortality Rates.

Hughes BG, Hekimi S.

Genetics. 2016 Nov;204(3):905-920. doi: 10.1534/genetics.116.192369. Epub 2016 Sep 16.


Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R.

Cell Metab. 2016 Jun 14;23(6):1093-1112. doi: 10.1016/j.cmet.2016.05.027.


Original Research: Metabolic alterations from early life thyroxine replacement therapy in male Ames dwarf mice are transient.

Darcy J, Fang Y, Hill CM, McFadden S, Sun LY, Bartke A.

Exp Biol Med (Maywood). 2016 Oct;241(16):1764-71. doi: 10.1177/1535370216650292. Epub 2016 May 13.


The impact of adjuvant chemotherapy in older breast cancer patients on clinical and biological aging parameters.

Brouwers B, Hatse S, Dal Lago L, Neven P, Vuylsteke P, Dalmasso B, Debrock G, Van Den Bulck H, Smeets A, Bechter O, Bailur JK, Kenis C, Laenen A, Schöffski P, Pawelec G, Journe F, Ghanem GE, Wildiers H.

Oncotarget. 2016 May 24;7(21):29977-88. doi: 10.18632/oncotarget.8796.


Measuring aging rates of mice subjected to caloric restriction and genetic disruption of growth hormone signaling.

Koopman JJ, van Heemst D, van Bodegom D, Bonkowski MS, Sun LY, Bartke A.

Aging (Albany NY). 2016 Mar;8(3):539-46.

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