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Items: 20


Direct observation of DNA threading in flap endonuclease complexes.

AlMalki FA, Flemming CS, Zhang J, Feng M, Sedelnikova SE, Ceska T, Rafferty JB, Sayers JR, Artymiuk PJ.

Nat Struct Mol Biol. 2016 Jul;23(7):640-6. doi: 10.1038/nsmb.3241. Epub 2016 Jun 6.


Shade avoidance 6 encodes an Arabidopsis flap endonuclease required for maintenance of genome integrity and development.

Zhang Y, Wen C, Liu S, Zheng L, Shen B, Tao Y.

Nucleic Acids Res. 2016 Feb 18;44(3):1271-84. doi: 10.1093/nar/gkv1474. Epub 2015 Dec 31.


Replisome Dynamics during Chromosome Duplication.

Kurth I, O'Donnell M.

EcoSal Plus. 2009 Aug;3(2). doi: 10.1128/ecosalplus.4.4.2.


The DNA Exonucleases of Escherichia coli.

Lovett ST.

EcoSal Plus. 2011 Dec;4(2). doi: 10.1128/ecosalplus.4.4.7.


Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins.

Shin DS, Pratt AJ, Tainer JA.

Archaea. 2014 Feb 20;2014:206735. doi: 10.1155/2014/206735. eCollection 2014. Review.


Flap endonuclease 1.

Balakrishnan L, Bambara RA.

Annu Rev Biochem. 2013;82:119-38. doi: 10.1146/annurev-biochem-072511-122603. Epub 2013 Feb 28. Review.


The wonders of flap endonucleases: structure, function, mechanism and regulation.

Finger LD, Atack JM, Tsutakawa S, Classen S, Tainer J, Grasby J, Shen B.

Subcell Biochem. 2012;62:301-26. doi: 10.1007/978-94-007-4572-8_16. Review.


Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends.

Patel N, Atack JM, Finger LD, Exell JC, Thompson P, Tsutakawa S, Tainer JA, Williams DM, Grasby JA.

Nucleic Acids Res. 2012 May;40(10):4507-19. doi: 10.1093/nar/gks051. Epub 2012 Feb 8.


Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases.

Grasby JA, Finger LD, Tsutakawa SE, Atack JM, Tainer JA.

Trends Biochem Sci. 2012 Feb;37(2):74-84. doi: 10.1016/j.tibs.2011.10.003. Epub 2011 Nov 24. Review.


Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily.

Tsutakawa SE, Classen S, Chapados BR, Arvai AS, Finger LD, Guenther G, Tomlinson CG, Thompson P, Sarker AH, Shen B, Cooper PK, Grasby JA, Tainer JA.

Cell. 2011 Apr 15;145(2):198-211. doi: 10.1016/j.cell.2011.03.004.


Functional regulation of FEN1 nuclease and its link to cancer.

Zheng L, Jia J, Finger LD, Guo Z, Zer C, Shen B.

Nucleic Acids Res. 2011 Feb;39(3):781-94. doi: 10.1093/nar/gkq884. Epub 2010 Oct 6. Review.


Flap endonuclease 1 mechanism analysis indicates flap base binding prior to threading.

Gloor JW, Balakrishnan L, Bambara RA.

J Biol Chem. 2010 Nov 5;285(45):34922-31. doi: 10.1074/jbc.M110.165902. Epub 2010 Aug 25.


Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates.

Stewart JA, Campbell JL, Bambara RA.

Nucleic Acids Res. 2010 Jan;38(3):920-30. doi: 10.1093/nar/gkp1055. Epub 2009 Nov 24.


The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis.

Finger LD, Blanchard MS, Theimer CA, Sengerová B, Singh P, Chavez V, Liu F, Grasby JA, Shen B.

J Biol Chem. 2009 Aug 14;284(33):22184-94. doi: 10.1074/jbc.M109.015065. Epub 2009 Jun 11.


Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids.

Dash C, Scarth BJ, Badorrek C, Götte M, Le Grice SF.

Nucleic Acids Res. 2008 Nov;36(20):6363-71. doi: 10.1093/nar/gkn678. Epub 2008 Oct 4.


Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease.

Williams R, Sengerová B, Osborne S, Syson K, Ault S, Kilgour A, Chapados BR, Tainer JA, Sayers JR, Grasby JA.

J Mol Biol. 2007 Aug 3;371(1):34-48. Epub 2007 May 1.


The Fen1 extrahelical 3'-flap pocket is conserved from archaea to human and regulates DNA substrate specificity.

Friedrich-Heineken E, Hübscher U.

Nucleic Acids Res. 2004 May 6;32(8):2520-8. Print 2004.


Interactions of mutant and wild-type flap endonucleases with oligonucleotide substrates suggest an alternative model of DNA binding.

Dervan JJ, Feng M, Patel D, Grasby JA, Artymiuk PJ, Ceska TA, Sayers JR.

Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8542-7.


Molecular interactions of human Exo1 with DNA.

Lee Bi BI, Nguyen LH, Barsky D, Fernandes M, Wilson DM 3rd.

Nucleic Acids Res. 2002 Feb 15;30(4):942-9.

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