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Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing?

Miclau KR, Brazina SA, Bahney CS, Hankenson KD, Hunt TK, Marcucio RS, Miclau T.

Front Cell Dev Biol. 2017 May 4;5:45. doi: 10.3389/fcell.2017.00045. eCollection 2017. Review.


Exogenous PTHrP Repairs the Damaged Fracture Healing of PTHrP+/- Mice and Accelerates Fracture Healing of Wild Mice.

Wang Y, Fang X, Wang C, Ding C, Lin H, Liu A, Wang L, Cao Y.

Int J Mol Sci. 2017 Feb 6;18(2). pii: E337. doi: 10.3390/ijms18020337.


The Nuclear Receptor AhR Controls Bone Homeostasis by Regulating Osteoclast Differentiation via the RANK/c-Fos Signaling Axis.

Izawa T, Arakaki R, Mori H, Tsunematsu T, Kudo Y, Tanaka E, Ishimaru N.

J Immunol. 2016 Dec 15;197(12):4639-4650. Epub 2016 Nov 14.


Osteogenic Differentiation of Periosteal Cells During Fracture Healing.

Wang T, Zhang X, Bikle DD.

J Cell Physiol. 2017 May;232(5):913-921. doi: 10.1002/jcp.25641. Epub 2016 Oct 26. Review.


Calvarial Defect Healing Induced by Small Molecule Smoothened Agonist.

Lee S, Shen J, Pan HC, Shrestha S, Asatrian G, Nguyen A, Meyers C, Nguyen V, Lee M, Soo C, Ting K, James AW.

Tissue Eng Part A. 2016 Dec;22(23-24):1357-1366. Epub 2016 Oct 18.


Analogous cellular contribution and healing mechanisms following digit amputation and phalangeal fracture in mice.

Dawson LA, Simkin J, Sauque M, Pela M, Palkowski T, Muneoka K.

Regeneration (Oxf). 2016 Mar 9;3(1):39-51. doi: 10.1002/reg2.51. eCollection 2016 Feb.


Identification of a New Cell Population Constitutively Circulating in Healthy Conditions and Endowed with a Homing Ability Toward Injured Sites.

Lo Sicco C, Tasso R, Reverberi D, Cilli M, Pfeffer U, Cancedda R.

Sci Rep. 2015 Nov 12;5:16574. doi: 10.1038/srep16574.


Hedgehog signaling mediates woven bone formation and vascularization during stress fracture healing.

Kazmers NH, McKenzie JA, Shen TS, Long F, Silva MJ.

Bone. 2015 Dec;81:524-32. doi: 10.1016/j.bone.2015.09.002. Epub 2015 Sep 6.


Periosteal PTHrP Regulates Cortical Bone Remodeling During Fracture Healing.

Wang M, Nasiri AR, Broadus AE, Tommasini SM.

Bone. 2015 Dec;81:104-11. doi: 10.1016/j.bone.2015.07.008. Epub 2015 Jul 9.


The multifaceted role of the vasculature in endochondral fracture repair.

Bahney CS, Hu DP, Miclau T 3rd, Marcucio RS.

Front Endocrinol (Lausanne). 2015 Feb 5;6:4. doi: 10.3389/fendo.2015.00004. eCollection 2015. Review.


HIF-1α regulates bone formation after osteogenic mechanical loading.

Tomlinson RE, Silva MJ.

Bone. 2015 Apr;73:98-104. doi: 10.1016/j.bone.2014.12.015. Epub 2014 Dec 23.


Calluses flex their muscles to align bone fragments during fracture repair.

Nguyen J, Alliston T.

Dev Cell. 2014 Oct 27;31(2):137-8. doi: 10.1016/j.devcel.2014.10.009.


Induction of fully stabilized cortical bone defects to study intramembranous bone regeneration.

McGee-Lawrence ME, Razidlo DF.

Methods Mol Biol. 2015;1226:183-92. doi: 10.1007/978-1-4939-1619-1_14.


Interaction of age and mechanical stability on bone defect healing: an early transcriptional analysis of fracture hematoma in rat.

Ode A, Duda GN, Geissler S, Pauly S, Ode JE, Perka C, Strube P.

PLoS One. 2014 Sep 4;9(9):e106462. doi: 10.1371/journal.pone.0106462. eCollection 2014.


The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration.

Fan L, Li J, Yu Z, Dang X, Wang K.

Biomed Res Int. 2014;2014:239356. doi: 10.1155/2014/239356. Epub 2014 May 11. Review.


Combined use of low-intensity pulsed ultrasound and rhBMP-2 to enhance bone formation in a rat model of critical size defect.

Angle SR, Sena K, Sumner DR, Virkus WW, Virdi AS.

J Orthop Trauma. 2014 Oct;28(10):605-11. doi: 10.1097/BOT.0000000000000067.


Periosteum: biology and applications in craniofacial bone regeneration.

Lin Z, Fateh A, Salem DM, Intini G.

J Dent Res. 2014 Feb;93(2):109-16. doi: 10.1177/0022034513506445. Epub 2013 Oct 2. Review.


Manipulating biological agents and cells in micro-scale volumes for applications in medicine.

Tasoglu S, Gurkan UA, Wang S, Demirci U.

Chem Soc Rev. 2013 Jul 7;42(13):5788-808. doi: 10.1039/c3cs60042d. Review.


MMP9 regulates the cellular response to inflammation after skeletal injury.

Wang X, Yu YY, Lieu S, Yang F, Lang J, Lu C, Werb Z, Hu D, Miclau T, Marcucio R, Colnot C.

Bone. 2013 Jan;52(1):111-9. doi: 10.1016/j.bone.2012.09.018. Epub 2012 Sep 23.


PlGF: a multitasking cytokine with disease-restricted activity.

Dewerchin M, Carmeliet P.

Cold Spring Harb Perspect Med. 2012 Aug 1;2(8). pii: a011056. doi: 10.1101/cshperspect.a011056. Review.

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