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Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection.

Al-Daghri NM, Pontremoli C, Cagliani R, Forni D, Alokail MS, Al-Attas OS, Sabico S, Riva S, Clerici M, Sironi M.

BMC Evol Biol. 2017 Feb 7;17(1):43. doi: 10.1186/s12862-017-0897-z.


Effects of G6pc2 deletion on body weight and cholesterol in mice.

Boortz KA, Syring KE, Pound LD, Mo H, Bastarache L, Oeser JK, McGuinness OP, Denny JC, O'Brien RM.

J Mol Endocrinol. 2017 Apr;58(3):127-139. doi: 10.1530/JME-16-0202. Epub 2017 Jan 25.


G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance.

Boortz KA, Syring KE, Lee RA, Dai C, Oeser JK, McGuinness OP, Wang JC, O'Brien RM.

Endocrinology. 2016 Nov;157(11):4133-4145. Epub 2016 Sep 21.


Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression.

Boortz KA, Syring KE, Pound LD, Wang Y, Oeser JK, O'Brien RM.

PLoS One. 2016 Sep 9;11(9):e0162439. doi: 10.1371/journal.pone.0162439. eCollection 2016.


Glycogen metabolism in humans.

Adeva-Andany MM, González-Lucán M, Donapetry-García C, Fernández-Fernández C, Ameneiros-Rodríguez E.

BBA Clin. 2016 Feb 27;5:85-100. doi: 10.1016/j.bbacli.2016.02.001. eCollection 2016 Jun. Review.


Novel stable isotope analyses demonstrate significant rates of glucose cycling in mouse pancreatic islets.

Wall ML, Pound LD, Trenary I, O'Brien RM, Young JD.

Diabetes. 2015 Jun;64(6):2129-37. doi: 10.2337/db14-0745. Epub 2014 Dec 31.


Multi-tissue computational modeling analyzes pathophysiology of type 2 diabetes in MKR mice.

Kumar A, Harrelson T, Lewis NE, Gallagher EJ, LeRoith D, Shiloach J, Betenbaugh MJ.

PLoS One. 2014 Jul 16;9(7):e102319. doi: 10.1371/journal.pone.0102319. eCollection 2014.


Moving on from GWAS: functional studies on the G6PC2 gene implicated in the regulation of fasting blood glucose.

O'Brien RM.

Curr Diab Rep. 2013 Dec;13(6):768-77. doi: 10.1007/s11892-013-0422-8.


Large scale meta-analyses of fasting plasma glucose raising variants in GCK, GCKR, MTNR1B and G6PC2 and their impacts on type 2 diabetes mellitus risk.

Wang H, Liu L, Zhao J, Cui G, Chen C, Ding H, Wang DW.

PLoS One. 2013 Jun 28;8(6):e67665. doi: 10.1371/journal.pone.0067665. Print 2013.


Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels.

Baerenwald DA, Bonnefond A, Bouatia-Naji N, Flemming BP, Umunakwe OC, Oeser JK, Pound LD, Conley NL, Cauchi S, Lobbens S, Eury E, Balkau B, Lantieri O; MAGIC Investigators, Dadi PK, Jacobson DA, Froguel P, O'Brien RM.

Diabetologia. 2013 Jun;56(6):1306-16. doi: 10.1007/s00125-013-2875-3. Epub 2013 Mar 19.


G6PC2: a negative regulator of basal glucose-stimulated insulin secretion.

Pound LD, Oeser JK, O'Brien TP, Wang Y, Faulman CJ, Dadi PK, Jacobson DA, Hutton JC, McGuinness OP, Shiota M, O'Brien RM.

Diabetes. 2013 May;62(5):1547-56. doi: 10.2337/db12-1067. Epub 2012 Dec 28.


Homozygosity mapping and whole-exome sequencing to detect SLC45A2 and G6PC3 mutations in a single patient with oculocutaneous albinism and neutropenia.

Cullinane AR, Vilboux T, O'Brien K, Curry JA, Maynard DM, Carlson-Donohoe H, Ciccone C; NISC Comparative Sequencing Program, Markello TC, Gunay-Aygun M, Huizing M, Gahl WA.

J Invest Dermatol. 2011 Oct;131(10):2017-25. doi: 10.1038/jid.2011.157. Epub 2011 Jun 16.


G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction.

Hayee B, Antonopoulos A, Murphy EJ, Rahman FZ, Sewell G, Smith BN, McCartney S, Furman M, Hall G, Bloom SL, Haslam SM, Morris HR, Boztug K, Klein C, Winchester B, Pick E, Linch DC, Gale RE, Smith AM, Dell A, Segal AW.

Glycobiology. 2011 Jul;21(7):914-24. doi: 10.1093/glycob/cwr023. Epub 2011 Mar 8.


Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.

Bouatia-Naji N, Bonnefond A, Baerenwald DA, Marchand M, Bugliani M, Marchetti P, Pattou F, Printz RL, Flemming BP, Umunakwe OC, Conley NL, Vaxillaire M, Lantieri O, Balkau B, Marre M, Lévy-Marchal C, Elliott P, Jarvelin MR, Meyre D, Dina C, Oeser JK, Froguel P, O'Brien RM.

Diabetes. 2010 Oct;59(10):2662-71. doi: 10.2337/db10-0389. Epub 2010 Jul 9.


Cytokine-induced dicing and splicing in the beta-cell and the immune response in type 1 diabetes.

Hutton JC, Davidson HW.

Diabetes. 2010 Feb;59(2):335-6. doi: 10.2337/db09-1767. No abstract available.


Glucose-6-phosphatase catalytic subunit gene family.

Hutton JC, O'Brien RM.

J Biol Chem. 2009 Oct 23;284(43):29241-5. doi: 10.1074/jbc.R109.025544. Epub 2009 Aug 20. Review.


A syndrome with congenital neutropenia and mutations in G6PC3.

Boztug K, Appaswamy G, Ashikov A, Schäffer AA, Salzer U, Diestelhorst J, Germeshausen M, Brandes G, Lee-Gossler J, Noyan F, Gatzke AK, Minkov M, Greil J, Kratz C, Petropoulou T, Pellier I, Bellanné-Chantelot C, Rezaei N, Mönkemöller K, Irani-Hakimeh N, Bakker H, Gerardy-Schahn R, Zeidler C, Grimbacher B, Welte K, Klein C.

N Engl J Med. 2009 Jan 1;360(1):32-43. doi: 10.1056/NEJMoa0805051. Erratum in: N Engl J Med. 2011 Apr 28;364(17):1682.


Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression.

Martin CC, Flemming BP, Wang Y, Oeser JK, O'Brien RM.

J Mol Endocrinol. 2008 Nov;41(5):315-28. doi: 10.1677/JME-08-0062. Epub 2008 Aug 27.


Endoplasmic reticulum stress caused by overexpression of islet-specific glucose-6-phosphatase catalytic subunit-related protein in pancreatic Beta-cells.

Shameli A, Yamanouchi J, Thiessen S, Santamaria P.

Rev Diabet Stud. 2007 Spring;4(1):25-32. Epub 2007 May 10.


Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells.

Matsuoka TA, Zhao L, Artner I, Jarrett HW, Friedman D, Means A, Stein R.

Mol Cell Biol. 2003 Sep;23(17):6049-62.

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