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Items: 10


Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase.

Smith P, Ho CK, Takagi Y, Djaballah H, Shuman S.

MBio. 2016 Feb 23;7(1):e00058-16. doi: 10.1128/mBio.00058-16.


A metazoan/plant-like capping enzyme and cap modified nucleotides in the unicellular eukaryote Trichomonas vaginalis.

Simoes-Barbosa A, Hirt RP, Johnson PJ.

PLoS Pathog. 2010 Jul 15;6(7):e1000999. doi: 10.1371/journal.ppat.1000999.


Nucleotide analogs and molecular modeling studies reveal key interactions involved in substrate recognition by the yeast RNA triphosphatase.

Issur M, Despins S, Bougie I, Bisaillon M.

Nucleic Acids Res. 2009 Jun;37(11):3714-22. doi: 10.1093/nar/gkp227. Epub 2009 Apr 16.


Polyphosphatase activity of CthTTM, a bacterial triphosphate tunnel metalloenzyme.

Jain R, Shuman S.

J Biol Chem. 2008 Nov 7;283(45):31047-57. doi: 10.1074/jbc.M805392200. Epub 2008 Sep 8.


Evidence for a capping enzyme with specificity for the trypanosome spliced leader RNA.

Ruan JP, Shen S, Ullu E, Tschudi C.

Mol Biochem Parasitol. 2007 Dec;156(2):246-54. Epub 2007 Sep 15.


Divergent subunit interactions among fungal mRNA 5'-capping machineries.

Takagi T, Cho EJ, Janoo RT, Polodny V, Takase Y, Keogh MC, Woo SA, Fresco-Cohen LD, Hoffman CS, Buratowski S.

Eukaryot Cell. 2002 Jun;1(3):448-57.


Bacteriophage T4 RNA ligase 2 (gp24.1) exemplifies a family of RNA ligases found in all phylogenetic domains.

Ho CK, Shuman S.

Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12709-14. Epub 2002 Sep 12. Erratum in: Proc Natl Acad Sci U S A 2002 Oct 15;99(21):13961.


RNA triphosphatase is essential in Schizosaccharomyces pombe and Candida albicans.

Pei Y, Schwer B, Saiz J, Fisher RP, Shuman S.

BMC Microbiol. 2001;1:29. Epub 2001 Nov 20.

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