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Items: 1 to 20 of 86

1.

Expression of human Bcl-xL (Ser49) and (Ser62) mutants in Caenorhabditis elegans causes germline defects and aneuploidy.

Baruah PS, Beauchemin M, Parker JA, Bertrand R.

PLoS One. 2017 May 8;12(5):e0177413. doi: 10.1371/journal.pone.0177413. eCollection 2017.

2.

BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides.

Ferdek PE, Jakubowska MA, Nicolaou P, Gerasimenko JV, Gerasimenko OV, Petersen OH.

Cell Death Dis. 2017 Mar 2;8(3):e2640. doi: 10.1038/cddis.2017.41.

3.

Dynamic Bcl-xL (S49) and (S62) Phosphorylation/Dephosphorylation during Mitosis Prevents Chromosome Instability and Aneuploidy in Normal Human Diploid Fibroblasts.

Baruah PS, Beauchemin M, Hébert J, Bertrand R.

PLoS One. 2016 Jul 11;11(7):e0159091. doi: 10.1371/journal.pone.0159091. eCollection 2016.

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Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1.

Beekman AM, Howell LA.

ChemMedChem. 2016 Apr 19;11(8):802-13. doi: 10.1002/cmdc.201500497. Epub 2015 Dec 23. Review.

7.

AlphaSpace: Fragment-Centric Topographical Mapping To Target Protein-Protein Interaction Interfaces.

Rooklin D, Wang C, Katigbak J, Arora PS, Zhang Y.

J Chem Inf Model. 2015 Aug 24;55(8):1585-99. doi: 10.1021/acs.jcim.5b00103. Epub 2015 Aug 7.

8.

Enrichment of druggable conformations from apo protein structures using cosolvent-accelerated molecular dynamics.

Kalenkiewicz A, Grant BJ, Yang CY.

Biology (Basel). 2015 Apr 21;4(2):344-66. doi: 10.3390/biology4020344.

9.

Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB-induced Bcl-xL for inhibition of apoptosis.

Schwartz C, Willebrand R, Huber S, Rupec RA, Wu D, Locksley R, Voehringer D.

Blood. 2015 Jun 18;125(25):3896-904. doi: 10.1182/blood-2014-10-607788. Epub 2015 Apr 10.

10.

Selectivity by small-molecule inhibitors of protein interactions can be driven by protein surface fluctuations.

Johnson DK, Karanicolas J.

PLoS Comput Biol. 2015 Feb 23;11(2):e1004081. doi: 10.1371/journal.pcbi.1004081. eCollection 2015 Feb.

11.

Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo.

Zhan W, Hu X, Yi J, An Q, Huang X.

Mol Med Rep. 2015 Jun;11(6):4142-8. doi: 10.3892/mmr.2015.3326. Epub 2015 Feb 10.

12.

Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation.

Keitel U, Scheel A, Thomale J, Halpape R, Kaulfuß S, Scheel C, Dobbelstein M.

Oncotarget. 2014 Dec 15;5(23):11778-91.

13.

Phosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a.

Jin L, Chen Y, Mu X, Lian Q, Deng H, Ge R.

Biomed Res Int. 2014;2014:123482. doi: 10.1155/2014/123482. Epub 2014 Aug 12.

14.

Targeting the apoptosis pathway in hematologic malignancies.

Zaman S, Wang R, Gandhi V.

Leuk Lymphoma. 2014 Sep;55(9):1980-92. doi: 10.3109/10428194.2013.855307. Epub 2014 Feb 4. Review.

15.

Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker.

Richard DJ, Lena R, Bannister T, Blake N, Pierceall WE, Carlson NE, Keller CE, Koenig M, He Y, Minond D, Mishra J, Cameron M, Spicer T, Hodder P, Cardone MH.

Bioorg Med Chem. 2013 Nov 1;21(21):6642-9. doi: 10.1016/j.bmc.2013.08.017. Epub 2013 Aug 15.

16.

Anti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors.

Liu Q, Wang HG.

Commun Integr Biol. 2012 Nov 1;5(6):557-65. doi: 10.4161/cib.21554.

17.

Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactions.

Raj M, Bullock BN, Arora PS.

Bioorg Med Chem. 2013 Jul 15;21(14):4051-7. doi: 10.1016/j.bmc.2012.11.023. Epub 2012 Dec 4.

18.

Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration.

Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JD, Bu G, Reed JC, Liao FF, Chen YG, Xu H.

J Neurosci. 2012 Oct 31;32(44):15565-76. doi: 10.1523/JNEUROSCI.3668-12.2012.

19.

Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression.

Chen J, Zhou H, Aguilar A, Liu L, Bai L, McEachern D, Yang CY, Meagher JL, Stuckey JA, Wang S.

J Med Chem. 2012 Oct 11;55(19):8502-14. doi: 10.1021/jm3010306. Epub 2012 Oct 2.

20.

A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.

Cohen NA, Stewart ML, Gavathiotis E, Tepper JL, Bruekner SR, Koss B, Opferman JT, Walensky LD.

Chem Biol. 2012 Sep 21;19(9):1175-86. doi: 10.1016/j.chembiol.2012.07.018.

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