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Items: 1 to 20 of 86

1.

Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation.

Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL.

Nat Cell Biol. 2017 Jul 28;19(8):996-1002. doi: 10.1038/ncb3581.

PMID:
28752853
2.

Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity.

Shah NG, Tulapurkar ME, Ramarathnam A, Brophy A, Martinez R 3rd, Hom K, Hodges T, Samadani R, Singh IS, MacKerell AD Jr, Shapiro P, Hasday JD.

J Immunol. 2017 Apr 15;198(8):3296-3306. doi: 10.4049/jimmunol.1602059. Epub 2017 Mar 15.

3.

Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist.

Pellegrini E, Palencia A, Braun L, Kapp U, Bougdour A, Belrhali H, Bowler MW, Hakimi MA.

Structure. 2017 Jan 3;25(1):16-26. doi: 10.1016/j.str.2016.10.011. Epub 2016 Nov 23.

4.

Selective Phosphorylation Inhibitor of Delta Protein Kinase C-Pyruvate Dehydrogenase Kinase Protein-Protein Interactions: Application for Myocardial Injury in Vivo.

Qvit N, Disatnik MH, Sho E, Mochly-Rosen D.

J Am Chem Soc. 2016 Jun 22;138(24):7626-35. doi: 10.1021/jacs.6b02724. Epub 2016 Jun 8.

5.

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death.

Qvit N, Joshi AU, Cunningham AD, Ferreira JC, Mochly-Rosen D.

J Biol Chem. 2016 Jun 24;291(26):13608-21. doi: 10.1074/jbc.M115.711630. Epub 2016 Apr 27.

6.

Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases.

Zeke A, Bastys T, Alexa A, Garai Á, Mészáros B, Kirsch K, Dosztányi Z, Kalinina OV, Reményi A.

Mol Syst Biol. 2015 Nov 3;11(11):837. doi: 10.15252/msb.20156269.

7.

Mapping the binding interface of ERK and transcriptional repressor Capicua using photocrosslinking.

Futran AS, Kyin S, Shvartsman SY, Link AJ.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8590-5. doi: 10.1073/pnas.1501373112. Epub 2015 Jun 29.

8.
9.

Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex.

Alexa A, Gógl G, Glatz G, Garai Á, Zeke A, Varga J, Dudás E, Jeszenői N, Bodor A, Hetényi C, Reményi A.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2711-6. doi: 10.1073/pnas.1417571112. Epub 2015 Feb 17.

10.

Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf.

Samadani R, Zhang J, Brophy A, Oashi T, Priyakumar UD, Raman EP, St John FJ, Jung KY, Fletcher S, Pozharski E, MacKerell AD Jr, Shapiro P.

Biochem J. 2015 May 1;467(3):425-38. doi: 10.1042/BJ20131571.

11.

A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia.

Willemen HL, Campos PM, Lucas E, Morreale A, Gil-Redondo R, Agut J, González FV, Ramos P, Heijnen C, Mayor F Jr, Kavelaars A, Murga C.

Biochem J. 2014 May 1;459(3):427-39. doi: 10.1042/BJ20130172.

12.

ERK as a model for systems biology of enzyme kinetics in cells.

Futran AS, Link AJ, Seger R, Shvartsman SY.

Curr Biol. 2013 Nov 4;23(21):R972-9. doi: 10.1016/j.cub.2013.09.033. Review.

13.

Molecular basis of MAP kinase regulation.

Peti W, Page R.

Protein Sci. 2013 Dec;22(12):1698-710. doi: 10.1002/pro.2374. Epub 2013 Oct 19. Review.

14.

Structural and functional characterization of the recombinant death domain from death-associated protein kinase.

Dioletis E, Dingley AJ, Driscoll PC.

PLoS One. 2013 Jul 29;8(7):e70095. doi: 10.1371/journal.pone.0070095. Print 2013.

15.

A Common Docking Domain in Progesterone Receptor-B links DUSP6 and CK2 signaling to proliferative transcriptional programs in breast cancer cells.

Hagan CR, Knutson TP, Lange CA.

Nucleic Acids Res. 2013 Oct;41(19):8926-42. doi: 10.1093/nar/gkt706. Epub 2013 Aug 5.

16.

Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling.

Jung KY, Samadani R, Chauhan J, Nevels K, Yap JL, Zhang J, Worlikar S, Lanning ME, Chen L, Ensey M, Shukla S, Salmo R, Heinzl G, Gordon C, Dukes T, MacKerell AD Jr, Shapiro P, Fletcher S.

Org Biomol Chem. 2013 Jun 14;11(22):3706-32. doi: 10.1039/c3ob40199e.

17.

Role for Prdx1 as a specific sensor in redox-regulated senescence in breast cancer.

Turner-Ivey B, Manevich Y, Schulte J, Kistner-Griffin E, Jezierska-Drutel A, Liu Y, Neumann CA.

Oncogene. 2013 Nov 7;32(45):5302-14. doi: 10.1038/onc.2012.624. Epub 2013 Jan 21.

18.

Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove.

Garai Á, Zeke A, Gógl G, Törő I, Fördős F, Blankenburg H, Bárkai T, Varga J, Alexa A, Emig D, Albrecht M, Reményi A.

Sci Signal. 2012 Oct 9;5(245):ra74. doi: 10.1126/scisignal.2003004.

19.

Dual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling.

Caunt CJ, Keyse SM.

FEBS J. 2013 Jan;280(2):489-504. doi: 10.1111/j.1742-4658.2012.08716.x. Epub 2012 Aug 28. Review.

20.

Heat shock protein 27 mediated signaling in viral infection.

Rajaiya J, Yousuf MA, Singh G, Stanish H, Chodosh J.

Biochemistry. 2012 Jul 17;51(28):5695-702. Epub 2012 Jul 5.

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