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Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance.

Nandipati KC, Subramanian S, Agrawal DK.

Mol Cell Biochem. 2017 Feb;426(1-2):27-45. doi: 10.1007/s11010-016-2878-8. Epub 2016 Nov 21. Review.


Complex cis-regulatory landscape of the insulin receptor gene underlies the broad expression of a central signaling regulator.

Wei Y, Gokhale RH, Sonnenschein A, Montgomery KM, Ingersoll A, Arnosti DN.

Development. 2016 Oct 1;143(19):3591-3603.


The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development.

Sumter TF, Xian L, Huso T, Koo M, Chang YT, Almasri TN, Chia L, Inglis C, Reid D, Resar LM.

Curr Mol Med. 2016;16(4):353-93. Review.


Quasi-Steady-State Analysis based on Structural Modules and Timed Petri Net Predict System's Dynamics: The Life Cycle of the Insulin Receptor.

Scheidel J, Lindauer K, Ackermann J, Koch I.

Metabolites. 2015 Dec 17;5(4):766-93. doi: 10.3390/metabo5040766.


The Association between HMGA1 rs146052672 Variant and Type 2 Diabetes: A Transethnic Meta-Analysis.

Bianco A, Chiefari E, Nobile CG, Foti D, Pavia M, Brunetti A.

PLoS One. 2015 Aug 21;10(8):e0136077. doi: 10.1371/journal.pone.0136077. eCollection 2015.


Network-Based Association Study of Obesity and Type 2 Diabetes with Gene Expression Profiles.

Zhang S, Wang B, Shi J, Li J.

Biomed Res Int. 2015;2015:619730. doi: 10.1155/2015/619730. Epub 2015 Jul 27.


Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer.

Wang T, Wang G, Hao D, Liu X, Wang D, Ning N, Li X.

Mol Cancer. 2015 Jun 30;14:125. doi: 10.1186/s12943-015-0402-5. Review.


A novel mechanism of post-translational modulation of HMGA functions by the histone chaperone nucleophosmin.

Arnoldo L, Sgarra R, Chiefari E, Iiritano S, Arcidiacono B, Pegoraro S, Pellarin I, Brunetti A, Manfioletti G.

Sci Rep. 2015 Feb 25;5:8552. doi: 10.1038/srep08552.


Cooperation between HMGA1, PDX-1, and MafA is Essential for Glucose-Induced Insulin Transcription in Pancreatic Beta Cells.

Arcidiacono B, Iiritano S, Chiefari E, Brunetti FS, Gu G, Foti DP, Brunetti A.

Front Endocrinol (Lausanne). 2015 Jan 13;5:237. doi: 10.3389/fendo.2014.00237. eCollection 2014.


Recent advances in the molecular genetics of type 2 diabetes mellitus.

Brunetti A, Chiefari E, Foti D.

World J Diabetes. 2014 Apr 15;5(2):128-40. doi: 10.4239/wjd.v5.i2.128. Review.


Transcriptional regulation of the HMGA1 gene by octamer-binding proteins Oct-1 and Oct-2.

Chiefari E, Arcidiacono B, Possidente K, Iiritano S, Ventura V, Pandolfo R, Brunetti FS, Greco M, Foti D, Brunetti A.

PLoS One. 2013 Dec 18;8(12):e83969. doi: 10.1371/journal.pone.0083969. eCollection 2013.


A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components.

Chiefari E, Tanyolaç S, Iiritano S, Sciacqua A, Capula C, Arcidiacono B, Nocera A, Possidente K, Baudi F, Ventura V, Brunetti G, Brunetti FS, Vero R, Maio R, Greco M, Pavia M, Hodoglugil U, Durlach V, Pullinger CR, Goldfine ID, Perticone F, Foti D, Brunetti A.

Sci Rep. 2013;3:1491. doi: 10.1038/srep01491.


LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans.

Singh R, De Aguiar RB, Naik S, Mani S, Ostadsharif K, Wencker D, Sotoudeh M, Malekzadeh R, Sherwin RS, Mani A.

Cell Metab. 2013 Feb 5;17(2):197-209. doi: 10.1016/j.cmet.2013.01.009.


Functional relationship between high mobility group A1 (HMGA1) protein and insulin-like growth factor-binding protein 3 (IGFBP-3) in human chondrocytes.

Gasparini G, De Gori M, Paonessa F, Chiefari E, Brunetti A, Galasso O.

Arthritis Res Ther. 2012 Oct 4;14(5):R207. doi: 10.1186/ar4045.


The HMGA1-IGF-I/IGFBP system: a novel pathway for modulating glucose uptake.

Iiritano S, Chiefari E, Ventura V, Arcidiacono B, Possidente K, Nocera A, Nevolo MT, Fedele M, Greco A, Greco M, Brunetti G, Fusco A, Foti D, Brunetti A.

Mol Endocrinol. 2012 Sep;26(9):1578-89. doi: 10.1210/me.2011-1379. Epub 2012 Jun 28.


Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms.

Arcidiacono B, Iiritano S, Nocera A, Possidente K, Nevolo MT, Ventura V, Foti D, Chiefari E, Brunetti A.

Exp Diabetes Res. 2012;2012:789174. doi: 10.1155/2012/789174. Epub 2012 Jun 4. Review.


HMGA1 is a novel downstream nuclear target of the insulin receptor signaling pathway.

Chiefari E, Nevolo MT, Arcidiacono B, Maurizio E, Nocera A, Iiritano S, Sgarra R, Possidente K, Palmieri C, Paonessa F, Brunetti G, Manfioletti G, Foti D, Brunetti A.

Sci Rep. 2012;2:251. doi: 10.1038/srep00251. Epub 2012 Feb 7.


Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk.

Marquez M, Huyvaert M, Perry JR, Pearson RD, Falchi M, Morris AP, Vivequin S, Lobbens S, Yengo L, Gaget S, Pattou F, Poulain-Godefroy O, Charpentier G, Carlsson LM, Jacobson P, Sjöström L, Lantieri O, Heude B, Walley A, Balkau B, Marre M, Froguel P, Cauchi S; DIAGRAM Consortium.

Diabetes. 2012 Feb;61(2):524-30. doi: 10.2337/db11-0728. Epub 2011 Dec 30.


Molecular mechanisms of insulin resistance in type 2 diabetes mellitus.

Saini V.

World J Diabetes. 2010 Jul 15;1(3):68-75. doi: 10.4239/wjd.v1.i3.68.


Pseudogenes: pseudo-functional or key regulators in health and disease?

Pink RC, Wicks K, Caley DP, Punch EK, Jacobs L, Carter DR.

RNA. 2011 May;17(5):792-8. doi: 10.1261/rna.2658311. Epub 2011 Mar 11. Review.

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