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Items: 15


Nerve growth factor modulates the tumor cells migration in ovarian cancer through the WNT/β-catenin pathway.

Li B, Cai S, Zhao Y, He Q, Yu X, Cheng L, Zhang Y, Hu X, Ke M, Chen S, Zou M.

Oncotarget. 2016 Dec 6;7(49):81026-81048. doi: 10.18632/oncotarget.13186.


The new and recurrent FLT3 juxtamembrane deletion mutation shows a dominant negative effect on the wild-type FLT3 receptor.

Sandhöfer N, Bauer J, Reiter K, Dufour A, Rothenberg M, Konstandin NP, Zellmeier E, Tizazu B, Greif PA, Metzeler KH, Hiddemann W, Polzer H, Spiekermann K.

Sci Rep. 2016 Jun 27;6:28032. doi: 10.1038/srep28032.


Genomic aberrations in spitzoid melanocytic tumours and their implications for diagnosis, prognosis and therapy.

Wiesner T, Kutzner H, Cerroni L, Mihm MC Jr, Busam KJ, Murali R.

Pathology. 2016 Feb;48(2):113-31. doi: 10.1016/j.pathol.2015.12.007. Epub 2016 Jan 18. Review.


TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines.

Pasini L, Re A, Tebaldi T, Ricci G, Boi S, Adami V, Barbareschi M, Quattrone A.

BMC Cancer. 2015 Oct 24;15:777. doi: 10.1186/s12885-015-1791-y.


TRKing down an old oncogene in a new era of targeted therapy.

Vaishnavi A, Le AT, Doebele RC.

Cancer Discov. 2015 Jan;5(1):25-34. doi: 10.1158/2159-8290.CD-14-0765. Epub 2014 Dec 19. Review.


TrkC expression predicts favorable clinical outcome in invasive ductal carcinoma of breast independent of NT-3 expression.

Zhang W, Lin ZC, Zhang TX, Liu S, Liu X, Liu JJ, Niu Y.

Am J Cancer Res. 2014 Nov 19;4(6):811-23. eCollection 2014.


Kinase fusions are frequent in Spitz tumours and spitzoid melanomas.

Wiesner T, He J, Yelensky R, Esteve-Puig R, Botton T, Yeh I, Lipson D, Otto G, Brennan K, Murali R, Garrido M, Miller VA, Ross JS, Berger MF, Sparatta A, Palmedo G, Cerroni L, Busam KJ, Kutzner H, Cronin MT, Stephens PJ, Bastian BC.

Nat Commun. 2014;5:3116. doi: 10.1038/ncomms4116.


ALK-activating homologous mutations in LTK induce cellular transformation.

Roll JD, Reuther GW.

PLoS One. 2012;7(2):e31733. doi: 10.1371/journal.pone.0031733. Epub 2012 Feb 9.


Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity.

Lambert QT, Pradhan A, Roll JD, Reuther GW.

Biochem J. 2011 Aug 15;438(1):155-64. doi: 10.1042/BJ20110351.


Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells.

Rao R, Nalluri S, Fiskus W, Balusu R, Joshi A, Mudunuru U, Buckley KM, Robbins K, Ustun C, Reuther GW, Bhalla KN.

Mol Cancer Ther. 2010 Aug;9(8):2232-42. doi: 10.1158/1535-7163.MCT-10-0336. Epub 2010 Jul 27.


Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells.

Chen LS, Redkar S, Bearss D, Wierda WG, Gandhi V.

Blood. 2009 Nov 5;114(19):4150-7. doi: 10.1182/blood-2009-03-212852. Epub 2009 Sep 4.


High-affinity neurotrophin receptors and ligands promote leukemogenesis.

Li Z, Beutel G, Rhein M, Meyer J, Koenecke C, Neumann T, Yang M, Krauter J, von Neuhoff N, Heuser M, Diedrich H, Göhring G, Wilkens L, Schlegelberger B, Ganser A, Baum C.

Blood. 2009 Feb 26;113(9):2028-37. doi: 10.1182/blood-2008-05-155200. Epub 2008 Dec 4.


Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.

Tomasson MH, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, Ries RE, Lubman O, Fremont DH, McLellan MD, Payton JE, Westervelt P, DiPersio JF, Link DC, Walter MJ, Graubert TA, Watson M, Baty J, Heath S, Shannon WD, Nagarajan R, Bloomfield CD, Mardis ER, Wilson RK, Ley TJ.

Blood. 2008 May 1;111(9):4797-808. doi: 10.1182/blood-2007-09-113027. Epub 2008 Feb 12.


Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor.

Pradhan A, Lambert QT, Reuther GW.

Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18502-7. Epub 2007 Nov 14.


AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.

Mulloy JC, Jankovic V, Wunderlich M, Delwel R, Cammenga J, Krejci O, Zhao H, Valk PJ, Lowenberg B, Nimer SD.

Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4016-21. Epub 2005 Feb 24.

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