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Items: 12


Prion infection promotes extensive accumulation of α-synuclein in aged human α-synuclein transgenic mice.

Masliah E, Rockenstein E, Inglis C, Adame A, Bett C, Lucero M, Sigurdson CJ.

Prion. 2012 Apr-Jun;6(2):184-90. doi: 10.4161/pri.19806. Epub 2012 Apr 1.


Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease.

Hook V, Funkelstein L, Wegrzyn J, Bark S, Kindy M, Hook G.

Biochim Biophys Acta. 2012 Jan;1824(1):89-104. doi: 10.1016/j.bbapap.2011.08.015. Epub 2011 Sep 8. Review.


Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.

Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, Zweckstetter M, Masliah E, Lashuel HA.

J Neurosci. 2010 Mar 3;30(9):3184-98. doi: 10.1523/JNEUROSCI.5922-09.2010.


Reduced IGF-1 signaling delays age-associated proteotoxicity in mice.

Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A.

Cell. 2009 Dec 11;139(6):1157-69. doi: 10.1016/j.cell.2009.11.014.


Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease.

Hook V, Schechter I, Demuth HU, Hook G.

Biol Chem. 2008 Aug;389(8):993-1006. doi: 10.1515/BC.2008.124. Review.


Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.

Nguyen TV, Galvan V, Huang W, Banwait S, Tang H, Zhang J, Bredesen DE.

J Neurochem. 2008 Feb;104(4):1065-80. Epub 2007 Nov 6.


Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model.

Reilly JF, Games D, Rydel RE, Freedman S, Schenk D, Young WG, Morrison JH, Bloom FE.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4837-42.


Filamentous phage as vector-mediated antibody delivery to the brain.

Frenkel D, Solomon B.

Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5675-9.

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